volume 105, issue 1-3, P61-69 1991
DOI: 10.1007/bf01245201
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Abstract: Two methods are described for the determination of two widely prescribed antidepressants, namely isocarboxazid and tranylcypromine sulphate as the pure drugs and in dosage forms. Both methods involve prior treatment with nitrous acid. In the spectrophotometric method, the two derivatives obey Beer's law over the concentration range 1-20/~g/ml. The derivatives are polarographically reducible with E1/2 values of -0.84 and -0.73 V for isocarboxazid and tranylcypromine sulphate, respectively. The calibration plot…

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