Point-of-use electroanalytical platform based on homemade potentiostat and smartphone for multivariate data processing

Giordano, Gabriela F.; Vicentini, Marcia B.R.; Murer, Rui C.; Augusto, Fábio; Ferrão, Marco Flôres; Helfer, Gilson Augusto; Costa, Adilson Ben da; Gobbi, Ângelo L.; Hantao, Leandro Wang; Lima, Renato S.

doi:10.1016/j.electacta.2016.09.157

Cited by 49 publications

(31 citation statements)

References 40 publications

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“…Recently more and more peripherals have begun using Bluetooth to wirelessly transmit data to and from the smartphone, as seen in the examples in Figure . The obvious benefit is that these types of peripherals are compatible with all types of smartphones regardless of the make or model.…”

Section: Integration With Smartphonementioning

confidence: 99%

“…Instead, when power can be traded for lower noise and smaller input bias current, custom potentiostat circuits with resistive feedback transimpedance amplifiers (R‐TIA) are designed to obtain a higher current resolution. The open source “CheapStat” potentiostat has a current resolution of 1 nA with tunable gain from 33–165 kΩ . Fan et al.…”

Section: Poc Implementations Of E‐chem Techniquesmentioning

confidence: 99%

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Point‐of‐Care Smartphone‐based Electrochemical Biosensing

Sun

Hall

2018

Electroanalysis

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Point‐of‐care (PoC) biosensors offer promising solutions to today's adverse and costly healthcare issues by moving diagnostic tools closer to the patient. The ubiquity of smartphones has brought about an emergence of PoC devices, which leverage the smartphone's capabilities, enabling the creation of low‐cost and portable biosensors. Electrochemical biosensors are well suited for PoC testing since the transducers can be miniaturized and inexpensively fabricated. This review paper discusses recent developments in smartphone‐based electrochemical biosensors for PoC diagnostics. These peripherals utilize the various connectivity options (for example proprietary ports, audio headphone‐jack, or wireless radio) to offload functionality to the smartphone. The smartphone‐based implementations of various electrochemical techniques, such as amperometry, potentiometry, and impedance spectroscopy are explored. Major challenges include reducing power, area, and cost of measurement circuitry, while maintaining adequate performance for PoC diagnostic applications.

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Section: Integration With Smartphonementioning

confidence: 99%

Section: Poc Implementations Of E‐chem Techniquesmentioning

confidence: 99%

Point‐of‐Care Smartphone‐based Electrochemical Biosensing

Sun

Hall

2018

Electroanalysis

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“…Ghoreishizadeh et al [35], Ainla et al [36], Giordano et al [37], and Steinberg et al [38] developed a wireless method of data acquisition and support miniaturisation of the biosensing platform by designing an amperometric potentiostat with a readout circuit to measure the differential current. Ghoreishizadeh et al [35] used an off-chip microcontroller which generates different profile voltages for the excitation of the potentiostat by means of a 10-bit DAC (Figure 12).…”

Section: Journal Of Sensorsmentioning

confidence: 99%

Potentiostats for Protein Biosensing: Design Considerations and Analysis on Measurement Characteristics

et al. 2019

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The demand for the development of swift, simple, and ultrasensitive biosensors has been increasing after the introduction of innovative approaches such as bioelectronics, nanotechnology, and electrochemistry. The possibility to correlate changes in electrical parameters with the concentration of protein biomarkers in biological samples is appealing to improve sensitivity, reliability, and repeatability of the biochemical assays currently available for protein investigation. Potentiostats are the required instruments to ensure the proper cell conditioning and signal processing in accurate electrochemical biosensing applications. In this light, this review is aimed at analyzing design considerations, electrical specifications, and measurement characteristics of potentiostats, specifically customized for protein detection. This review demonstrates how a proper potentiostat for protein quantification should be able to supply voltages in a range between few mV to few V, with high resolution in terms of readable current (in the order of 100 pA). To ensure a reliable quantification of clinically relevant protein concentrations (>1 ng/mL), the accuracy of the measurement (<1%) is significant and it can be ensured with proper digital-to-analog (10-16 bits) and analog-to-digital (10-24 bits) converters. Furthermore, the miniaturisation of electrochemical systems represents a key step toward portable, real-time, and fast point-of-care applications. This review is meant to serve as a guide for the design of customized potentiostats capable of a more proper and enhanced conditioning of electrochemical biosensors for protein detection.

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“…The use of CV as a measuring technique has been highly explored, and so, the most common small, integrated or low-cost approximations of these equipment are based on the CV feature [9,11,[14][15][16]. Additionally, the CV is a very useful technique in the identification of oxidation-reduction (Redox) processes, an can be a meaningful tool for the measuring of portable biosensors [10,11,13,14,[16][17][18][19][20]. The present work proposes the design and assembling of a low cost potentiostat as an alternative to develop a low cost miniaturized system for remote biosensing, which is able to run cyclic voltammetry measurements.…”

Section: Introductionmentioning

confidence: 99%

“…This GUI is usually developed to work on a PC through a USB connection [11][12][13], while other approaches are targeting the communication to mobile phones and their operational systems (e.g. Android OS) [10].…”

Section: Introductionmentioning

confidence: 99%

Miniaturization of Cyclic Voltammetry Electronic Systems for Remote Biosensing

Osma¹

2017

IJBSBE

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Point-of-use electroanalytical platform based on homemade potentiostat and smartphone for multivariate data processing

Cited by 49 publications

References 40 publications

Point‐of‐Care Smartphone‐based Electrochemical Biosensing

Point‐of‐Care Smartphone‐based Electrochemical Biosensing

Potentiostats for Protein Biosensing: Design Considerations and Analysis on Measurement Characteristics

Miniaturization of Cyclic Voltammetry Electronic Systems for Remote Biosensing

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