2011
DOI: 10.3174/ajnr.a2621
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Abstract: SUMMARY: POC testing is defined as diagnostic testing at or near the site of patient care. Rapid measurement of the intensity of anticoagulation and, more recently, platelet inhibition allows dose titration of adjuvant medications such a heparin and antiplatelet agents during neuroendovascular procedures. However, knowledge among practicing physicians regarding the pathophysiologic basis of these measurements and variations in knowledge about the differences among devices is often limited. This review discusse… Show more

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Cited by 14 publications
(13 citation statements)
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References 81 publications
(51 reference statements)
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“…Direct thrombin inhibitors (DTI) prevent thrombin activity in free plasma and at the thrombus. Lepirudin, Bivalirudin, argatroban, and Fondaparinux are in this category of anticoagulants (Hussein et al, 2012). Consequently, they block conversion of fibrinogen into fibrin, decreasing thrombin generation which affects the amplification and propagation of coagulation.…”
Section: Future Perspectives Novel Anticoagulant Therapiesmentioning
confidence: 99%
See 1 more Smart Citation
“…Direct thrombin inhibitors (DTI) prevent thrombin activity in free plasma and at the thrombus. Lepirudin, Bivalirudin, argatroban, and Fondaparinux are in this category of anticoagulants (Hussein et al, 2012). Consequently, they block conversion of fibrinogen into fibrin, decreasing thrombin generation which affects the amplification and propagation of coagulation.…”
Section: Future Perspectives Novel Anticoagulant Therapiesmentioning
confidence: 99%
“…All anticoagulants affect factors of the intrinsic and common pathways except warfarin which reduces the rate of hepatic synthesis of factor VII. This figure is reproduced from American Journal of Neuroradiology, 2012 (Hussein et al, 2012).…”
Section: Artificial Intelligence In Diagnosis and Monitoringmentioning
confidence: 99%
“…During AF ablation, it is now recommended to achieve and maintain an ACT of 300 to 400 seconds in order to reduce the risk of systemic thromboembolism [111]. However, the ACT is affected by a lot of preanalytical [112] and analytical variables [113, 114]. Finally, target ACT should be redetermined for the periprocedural use of NOACs for AF ablation [111117].…”
Section: Laboratory Testing For Noacs In a Perioperative Settingmentioning
confidence: 99%
“…The measurement of the intensity of anticoagulation by activated coagulation time requires understanding of the methods and instruments used for such measurements. 41 Unlike unfractionated heparin and low-molecular-weight heparin, direct thrombin inhibitors such as bivalirudin (Angiomax; The Medicines Company, Parsippany, New Jersey), lepirudin (Refludan; Bayer), or argatroban (Argatroban; GlaxoSmithKline, Research Triangle Park, North Carolina) are antithrombin III-independent inhibitors of thrombin that are effective against thrombin even after it binds to fibrin. Direct thrombin inhibitors are not associated with heparin-induced thrombocytopenia.…”
Section: Heparin Low-molecular-weight Heparin and Direct Thrombin Imentioning
confidence: 99%