1988
DOI: 10.1001/archderm.124.3.366
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Poikilodermatous mycosis fungoides and atrophic large-plaque parapsoriasis exhibit similar abnormalities of T-cell antigen expression

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Cited by 22 publications
(21 citation statements)
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“…22 It has been reported that CD8-positive MF follows a more aggressive course if the neoplastic cells are CD2-negative and CD7-positive. 26 However, none of the patients with a cytotoxic phenotype in the current study had loss of CD2 expression, and only 1 of 12 patients with a cytotoxic phenotype experienced disease progression.…”
Section: Immunophenotypecontrasting
confidence: 53%
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“…22 It has been reported that CD8-positive MF follows a more aggressive course if the neoplastic cells are CD2-negative and CD7-positive. 26 However, none of the patients with a cytotoxic phenotype in the current study had loss of CD2 expression, and only 1 of 12 patients with a cytotoxic phenotype experienced disease progression.…”
Section: Immunophenotypecontrasting
confidence: 53%
“…A previous review of immunophenotypes in 14 patients (age range, 18 -54 years) with poikilodermatous MF found that 13 (93%) were CD4-positive and only 1 patient had a predominantly cytotoxic (CD8-positive) phenotype, a similar profile to that observed in classic patch-stage, adult-onset MF. 26 The median age of disease onset in this cohort was 26 years, considerably younger than the median age typically reported among patients with MF. Lindae et al 26 concluded that the immunophenotype of poikilodermatous MF is similar to that of classic MF.…”
Section: Immunophenotypementioning
confidence: 60%
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“…The first and last of these features are virtually 100% specific for T-cell lymphoma but only about 10% sensitive for early MF. 45,85,89,90 CD7 deficiency is about 40% sensitive and 80% specific based on the same literature and our general experience.…”
Section: Immunopathologic Criteriamentioning
confidence: 56%
“…These include the precise definition of antigen deficiency, tissue processing, primary antibody used, patient age, and selection of controls. 45,52,56,[85][86][87][88][89] For frozen tissue, primary antibodies Leu-9, B-B7, and 3A1 that define CD7 have been used. The best sensitivity in frozen sections (59%-88%) has been achieved with Leu-9 and B-B7, with reported specificity of 87%-98%.…”
Section: Early Diagnosis Of Mf: the Role Of Ancillary Techniquesmentioning
confidence: 99%