Poikiloderma atrophicans vasculare

Dougherty, John W.

doi:10.1001/archderm.103.5.550

Cited by 9 publications

(5 citation statements)

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“…Poikiloderma atrophicans vasculare, as described by Jacobi in 1906, represents a poikilodermatous variant of CTCL 3 . This rare disorder has also been referred to as the lichenoid type of MF.…”

Section: Discussionmentioning

confidence: 99%

Poikilodermatous mycosis fungoides

et al. 2007

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A 60-year-old woman presented with a 10-year history of pruritic patch lesions that had originated on her breast and progressed over the years to involve the lower part of the abdomen. Different cutaneous biopsies were obtained during this period revealing a superficial chronic dermatitis. She had been treated previously with intermittent cycles of medium-strength topical steroids. This regimen was of only temporary benefit and progression of the skin lesions had occurred over the last year. The patient's medical history was otherwise unremarkable.Physical examination revealed atrophic red-brown skin with telangiectasia predominantly located on the breast (Fig. 1). Clinical examination also revealed various red-to-brown scaly plaques affecting the lower part of the abdomen.Two skin biopsies were obtained from the breast and the abdomen. Routine hematoxylin and eosin staining of the breast area revealed an atrophic epidermis covered by a scale of hyperkeratosis and parakeratosis. Scattered intraepidermal atypical lymphocytes were observed. In the dermis, there was a superficial band-like infiltrate of atypical lymphocytes sparing the dermo-epidermal interface. Pigmentary incontinence and dilated capillaries were present within the superficial dermis (Fig. 2). All of these findings were compatible with the poikilodermatous variant of cutaneous T-cell lymphoma (CTCL). Plaques affecting the lower part of the abdomen showed clinical features of classic mycosis fungoides (MF), and histology revealed an epidermis with acanthosis, a dense band-like infiltrate within the upper dermis, and a prominent epidermotropism with intraepidermal collections of lymphocytes.Immunohistochemical analysis of both biopsies identified the cells as CD2+, CD3+, CD4+, CD8-. Further detailed examination did not reveal any visceral or lymph node involvement.When topical mechlorethamine had no significant effect, psoralen plus UV-A (PUVA)phototherapy was started at 0.5 J/cm 2 twice weekly. After 20 treatments (cumulative dose, 143.5 J/cm 2 ), the lesions had disappeared, leaving slight postinflammatory hyperpigmentation.No maintenance treatment was required and the patient remained in complete remission during a 14-month follow-up period.

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Section: Discussionmentioning

confidence: 99%

Poikilodermatous mycosis fungoides

et al. 2007

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“…19). In some patients, the poikilodermic areas can predominate or even be the only finding 113–116 . Patients with universal poikiloderma involving the whole integument have been reported 117…”

Section: Poikilodermic Mfmentioning

confidence: 99%

Clinicopathological spectrum of mycosis fungoides

Kazakov

Burg

Kempf

2004

Acad Dermatol Venereol

240

225

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Cutaneous lymphomas represent a heterogeneous group of T-, NK- and B-cell neoplasms, with mycosis fungoides (MF) being the most common subtype. MF has a plethora of clinicopathological manifestations. Many variants of this lymphoma differ substantially from the 'classical' Alibert-Bazin disease and are therefore sometimes referred to as 'atypical' forms of the disease. This review addresses the whole clinicopathological spectrum of mycosis fungoides with respect to epidemiology, clinical, histopathological, immunophenotypic and genotypic features and the clinical course and prognosis of its variants: classical, erythrodermic, follicular, syringotropic, bullous/vesicular, granulomatous, poikilodermic, hypo- and hyperpigmented, unilesional, palmoplantar, hyperkeratotic/verrucous, vegetating/papillomatous, ichthyosiform, pigmented purpura-like, pustular and mucosal involvement in MF.

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“…Histopathology of poikilodermatous lesions discloses an atypical T-cell infiltrate in the papillary dermis, often with evident epidermotropism (1,13). However, Pautrier microabscesses are not as common in comparison to classic MF.…”

Section: Introductionmentioning

confidence: 99%