Podoplanin-positive cells are a hallmark of encapsulating peritoneal sclerosis

Braun, Niko; Alscher, Mark Dominik; Fritz, Péter; Edenhofer, Ilka; Kimmel, Martin; Gaspert, Ariana; Reimold, Fabian R.; Bode-Lesniewska, Beata; Ziegler, Urs; Biegger, Dagmar; Wüthrich, Rudolf P.; Segerer, Stephan

doi:10.1093/ndt/gfq488

Cited by 49 publications

(61 citation statements)

References 20 publications

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“…The excessive fibrotic peritoneal thickening in EPS is, in some respects, histologically different from simple fibrosis (5,28). However, we still do not know whether EPS is an independent disease or the result of a long-lasting disease process aggravated by a so-called second hit (29,30).…”

Section: Discussionmentioning

confidence: 99%

Phenotypes of Encapsulating Peritoneal Sclerosis—Macroscopic Appearance, Histologic Findings, and Outcome

Latus

Ulmer

Fritz³

et al. 2013

Perit Dial Int

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♦ Background: Encapsulating peritoneal sclerosis (EPS) is a rare but devastating complication of peritoneal dialysis (PD), with clinical signs of abdominal pain, bowel obstruction, and weight loss in late stages. ♦ Methods: We retrospectively analyzed all patients who were diagnosed with EPS between March 1998 and October 2011 in our department of nephrology. We focused on the 24 EPS patients who underwent surgery because of symptomatic late-stage EPS. We identified 3 different macroscopic phenotypes of EPS that we categorized as types I -III. We correlated histologic findings with those macroscopic phenotypes of EPS. The postoperative and long-term outcomes were evaluated by macroscopic phenotype. ♦ Results: Duration of PD was longer in type III than in types I and II EPS (p = 0.05). We observed no other statistically significant differences between the groups in baseline characteristics, except for operation time, which was longer in the type I than in the type III group (p = 0.02). Furthermore, we observed no statistically significant difference between the groups with respect to the onset of complaints before surgery (7.8 ± 5.9 months vs 7.0 ± 7.0 months vs 6.5 ± 5.3 months). Concerning patient outcomes, there was no evidence that any of the macroscopic EPS types was associated with more major or minor complications after surgery. For all study patients, follow-up was at least 3 years, with 19 patients still being alive, and 16 having no or very mild complaints. The typical histologic findings of EPS were present in all macroscopic types; only fibrin deposits were more prominent in type II than in type III.

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Section: Discussionmentioning

confidence: 99%

Phenotypes of Encapsulating Peritoneal Sclerosis—Macroscopic Appearance, Histologic Findings, and Outcome

Latus

Ulmer

Fritz³

et al. 2013

Perit Dial Int

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“…For example, peritoneal sclerosis, a fibrotic thickening of the abdominal serosal membranes, is frequently observed following peritoneal dialysis (Devuyst et al, 2010). Mesothelial cells have recently been recognized both as a source of fibrotic cells and a signaling center for aberrant vasculogenesis (Aroeira et al, 2005;Braun et al, 2011;Yáñez-Mó et al, 2003;Yung and Chan, 2009). In another example, pulmonary fibrosis is first observed as a fibrotic thickening just below the pulmonary mesothelium that progressively moves inwards (King et al, 2011).…”

Section: Research Articlementioning

confidence: 99%

Identification of a novel developmental mechanism in the generation of mesothelia

2012

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SUMMARYMesothelium is the surface layer of all coelomic organs and is crucial for the generation of their vasculature. Still, our understanding of the genesis of this essential cell type is restricted to the heart where a localized exogenous population of cells, the proepicardium, migrates to and envelops the myocardium supplying mesothelial, vascular and stromal cell lineages. Currently it is not known whether this pattern of development is specific to the heart or applies broadly to other coelomic organs. Using two independent long-term lineage-tracing studies, we demonstrate that mesothelial progenitors of the intestine are intrinsic to the gut tube anlage. Furthermore, a novel chick-quail chimera model of gut morphogenesis reveals these mesothelial progenitors are broadly distributed throughout the gut primordium and are not derived from a localized and exogenous proepicardium-like source of cells. These data demonstrate an intrinsic origin of mesothelial cells to a coelomic organ and provide a novel mechanism for the generation of mesothelial cells.

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“…Currently, anti-podoplanin antibodies are considered to be lymphatic and fibroblast markers (11)(12)(13). To assess angiogenesis and lymphangiogenesis in the visceral and the parietal peritoneal membrane in EPS, we applied immunohistochemistry for the endothelial markers CD34 (blood vessels) and podoplanin (lymphatic vessels) and the cell-proliferation marker Ki-67, and we performed immunogold microscopy analysis for podoplanin.…”

mentioning

confidence: 99%

Increased Lymphatic Vessels in Patients with Encapsulating Peritoneal Sclerosis

Yaginuma¹,

Yamamoto²,

Yamamoto³

et al. 2012

Perit Dial Int

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♦ Background: The angiogenic response is partly involved in the progression of encapsulating peritoneal sclerosis (EPS). However, the details of the angiogenic response, especially for lymphatic vessels in patients with EPS, remain unclear. In addition, because of technical limitations, morphology studies reported to date have examined only the parietal peritoneum. The morphologies of parietal and visceral lymphatic vessels in patients with EPS both need to be analyzed. ♦ Methods: We examined peritoneal samples from 18 patients with EPS who underwent enterolysis of the visceral peritoneum and compared them with samples from 17 autopsy cases (controls). To examine the angiogenic response, we performed immunohistochemistry for the endothelial markers CD34 (blood vessels) and podoplanin (lymphatic vessels) and for the cell proliferation marker Ki-67. Immunogold electron microscopy analysis for podoplanin was also performed. In 7 of 18 cases, we compared differences in the angiogenic response of the parietal and visceral peritoneal membranes.

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Podoplanin-positive cells are a hallmark of encapsulating peritoneal sclerosis

Abstract: EPS is characterized by a population of podoplanin and smooth muscle actin double-positive cells. Podoplanin might be a suitable morphological marker supporting the diagnosis and might be involved in the pathogenesis of EPS.

Cited by 49 publications

References 20 publications

Phenotypes of Encapsulating Peritoneal Sclerosis—Macroscopic Appearance, Histologic Findings, and Outcome

Phenotypes of Encapsulating Peritoneal Sclerosis—Macroscopic Appearance, Histologic Findings, and Outcome

Identification of a novel developmental mechanism in the generation of mesothelia

Increased Lymphatic Vessels in Patients with Encapsulating Peritoneal Sclerosis

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