Po-169 Brachytherapy for Young Prostate Cancer Patients. What Is Different From Elder Patients?

Yagi, Yasuto; Ashikari, Asuka; Namitome, Ryo; Nishiyama, Toru; Toya, Kazuhito; Yorozu, A.; Saito, S

doi:10.1016/s0167-8140(12)72135-7

Cited by 2 publications

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“…Of the 8 single institution studies examining SPC following BT without comparisons to other population groups ( Supplemetary Material Table 5 ), crude rates range from 0% for any SPC, bladder and rectal cancer up to 11.1%, 5.5% and 10.4% for any SPC, second rectal and second bladder cancers respectively [45–52] . It is likely that some studies have insufficient follow-up to detect all SPCs and that other single institution studies contain a relatively small number of patients.…”

Section: Resultsmentioning

confidence: 99%

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Second primary cancers after radiation for prostate cancer: A systematic review of the clinical data and impact of treatment technique

Murray

Henry

Hoskin

et al. 2014

Radiotherapy and Oncology

126

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The development of a radiation induced second primary cancer (SPC) is one the most serious long term consequences of successful cancer treatment. This review aims to evaluate SPC in prostate cancer (PCa) patients treated with radiotherapy, and assess whether radiation technique influences SPC. A systematic review of the literature was performed to identify studies examining SPC in irradiated PCa patients. This identified 19 registry publications, 21 institutional series and 7 other studies. There is marked heterogeneity in published studies. An increased risk of radiation-induced SPC has been identified in several studies, particularly those with longer durations of follow-up. The risk of radiation-induced SPC appears small, in the range of 1 in 220 to 1 in 290 over all durations of follow-up, and may increase to 1 in 70 for patients followed up for more than 10 years, based on studies which include patients treated with older radiation techniques (i.e. non-conformal, large field). To date there are insufficient clinical data to draw firm conclusions about the impact of more modern techniques such as IMRT and brachytherapy on SPC risk, although limited evidence is encouraging. In conclusion, despite heterogeneity between studies, an increased risk of SPC following radiation for PCa has been identified in several studies, and this risk appears to increase over time. This must be borne in mind when considering which patients to irradiate and which techniques to employ.

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Section: Resultsmentioning

confidence: 99%

“…The age of the patient population may also have an impact. For example, Yagi et al reported no cases of SPC in patients aged less than 60 but a crude rate of 7.6% in patients aged over 60, after median follow-up of 4.3 years [50] .…”

Section: Resultsmentioning

confidence: 99%