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Design of screen-printed potentiometric platform for sensitive determination of mirabegron in spiked human plasma; molecular docking and transducer optimization

“…Penalty points were calculated for the proposed electrochemical method and the reported method for the determination of MIR. 4 The proposed method showed a better score (eco-score = 88) than the reported method (eco-score = 76) due to the use of a large amount of acetonitrile organic solvent (Table 6). AGREE metric 32 was also used to evaluate the method greenness.…”

“…Bladogra® tablets, batch number (AT02880322), were manufactured by APEX Pharma, Egypt, and labelled to contain 50 mg of MIR per tablet. High molecular weight polyvinyl chloride (PVC), 2-nitrophenyl octyl ether (o-NPOE), potassium tetrakis(4-chlorophenyl)borate (K-TCPB), calix [4]arene (CX-4), calix [6]arene (CX-6), calix [8]arene (CX-8). Carbon screen-printed electrodes (SPE) 3 mm diameter were purchased from CH Instruments, Inc. (USA).…”

“…The results obtained by the GNP SP sensor VII were compared with those obtained by applying the reported method for the determination of MIR pure sample. 4 The t and F test values were used to compare the mean and variance between the two compared methods where no signicant difference in the results was found (Table 5).…”

“…4.0 × 10 −7 2.4 × 10 −Average of three determinations (n = 9). b Repeatability: the intraday precision (n = 9), average of three concentrations repeated three times within the day.…”

Unique liquid chromatography technique for the determination of mirabegron in the presence of polymers; robustness by Design Expert in the light of Quality by Design

“…Few authors have reported a UV spectrophotometric method for bulk drug analysis (Ravisankar et al, 2016;Suresh et al, 2020) or LC/MS and thin-layer chromatography methods for clinical analysis (Shah et al, 2019;Van Teijlingen et al, 2012). Several authors have reported methods for determining MBN by liquid chromatography (Ramazani & Rezaei, 2018;Sankar et al, 2020;Spandana et al, 2016;Suryawanshi et al, 2020;Yehia et al, 2017), but there is lack of research and they were limited to assay quantification. These reported liquid chromatography methods are tabulated in Table 1 and observations are commented.…”