Pneumoperitoneum Aggravates Renal Function in Cases of Decompensated But Not Compensated Experimental Congestive Heart Failure: Role of Nitric Oxide

Bishara, Bishara; Abu-Saleh, Niroz; Awad, Hoda; Goltsman, Ilia; Ramadan, Rawi; Khamaysi, Iyad; Abassi, Zaid

doi:10.1016/j.juro.2011.03.040

Cited by 12 publications

(15 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, they found in another study that rats with decompensated congestive heart failure were more susceptible to the adverse renal effects of pneumoperitoneum when pretreated with L-NAME, implying a higher susceptibility to kidney function deterioration in patients with cardiovascular diseases. 10 The results of our study support these previous studies by showing actual decreases in the expression and activity of eNOS with increasing IAP. This would have resulted in a diminished amount of endothelium-derived NO and thus a decrease in its anti-inflammatory and antioxidant actions.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Effect of Pneumoperitoneum on Oxidative Stress and Inflammation via the Arginase Pathway in Rats

Shin

Kim

et al. 2016

Yonsei Med J

View full text Add to dashboard Cite

PurposeOxidative stress during CO2 pneumoperitoneum is reported to be associated with decreased bioactivity of nitric oxide (NO). However, the changes in endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), and arginase during CO2 pneumoperitoneum have not been elucidated.Materials and MethodsThirty male Sprague-Dawley rats were randomized into three groups. After anesthesia induction, the abdominal cavities of the rats of groups intra-abdominal pressure (IAP)-10 and IAP-20 were insufflated with CO2 at pressures of 10 mm Hg and 20 mm Hg, respectively, for 2 hours. The rats of group IAP-0 were not insufflated. After deflation, plasma NO was measured, while protein expression levels and activity of eNOS, iNOS, arginase (Arg) I, and Arg II were analyzed with aorta and lung tissue samples.ResultsPlasma nitrite concentration and eNOS expression were significantly suppressed in groups IAP-10 and IAP-20 compared to IAP-0. While expression of iNOS and Arg I were comparable between the three groups, Arg II expression was significantly greater in group IAP-20 than in group IAP-0. Activity of eNOS was significantly lower in groups IAP-10 and IAP-20 than in group IAP-0, while iNOS activity was significantly greater in group IAP-20 than in groups IAP-0 and IAP-10. Arginase activity was significantly greater in group IAP-20 than in groups IAP-0 and IAP-10.ConclusionThe activity of eNOS decreases during CO2 pneumoperitoneum, while iNOS activity is significantly increased, a change that contributes to increased oxidative stress and inflammation. Moreover, arginase expression and activity is increased during CO2 pneumoperitoneum, which seems to act inversely to the NO system.

show abstract

Section: Discussionsupporting

confidence: 91%

“… 2 9 On the other hand, pretreatment with NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NOS, was shown to aggravate renal ischemia. 2 10 …”

Section: Introductionmentioning

confidence: 99%

Effect of Pneumoperitoneum on Oxidative Stress and Inflammation via the Arginase Pathway in Rats

Shin

Kim

et al. 2016

Yonsei Med J

View full text Add to dashboard Cite

show abstract

“…Concerning the latter, previous studies from our laboratory have demonstrated impairment in NO‐mediated renal vasodilation induced by acetylcholine and the NO donor S ‐nitroso‐ N ‐acetylpenicillamine in experimental CHF,, as well as an attenuated renal and systemic response to atrial natriuretic peptide (ANP) ,. On the other hand, rats with CHF display preserved integrity of the renal NO system, as evidenced by comparable urinary excretion of basal NO 2 +NO 3 compared with sham controls . Likewise, in the current study, we demonstrated that basal urinary excretion of cGMP, the second messenger of NP and NO systems, is preserved in rats with LAD ligation and is even significantly higher in rats with decompensated CHF induced by ACF as compared with sham controls.…”

Section: Discussionsupporting

confidence: 81%

“…These initial studies also demonstrated that rats with decompensated CHF displayed lower urinary excretion of NO 2 +NO 3 in association with reduced glomerular filtration rate (GFR), renal plasma flow (RPF), and urine flow when exposed to elevated IAP, compared with normal controls or compensated CHF animals . Furthermore, nitric oxide (NO) synthase inhibition with nitro‐l‐arginine methyl ester was found to render rats with compensated CHF more susceptible to the adverse renal effects of increased IAP . These findings suggest that perturbations in the generation of cGMP, a second messenger of NO and natriuretic peptides (NPs), may contribute to the deleterious effects of IAP in CHF.…”

Section: Introductionmentioning

confidence: 96%

“…Previously, we showed that rats with decompensated congestive heart failure (CHF) were more vulnerable to the adverse renal effects of increased IAP as compared with compensated CHF rats and normal controls . These initial studies also demonstrated that rats with decompensated CHF displayed lower urinary excretion of NO 2 +NO 3 in association with reduced glomerular filtration rate (GFR), renal plasma flow (RPF), and urine flow when exposed to elevated IAP, compared with normal controls or compensated CHF animals . Furthermore, nitric oxide (NO) synthase inhibition with nitro‐l‐arginine methyl ester was found to render rats with compensated CHF more susceptible to the adverse renal effects of increased IAP .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phosphodiesterase 5 inhibition protects against increased intra‐abdominal pressure‐induced renal dysfunction in experimental congestive heart failure

Bishara

Abu-Saleh

Awad

et al. 2012

European J of Heart Fail

Self Cite

View full text Add to dashboard Cite

AimsCongestive heart failure (CHF) is associated with impaired renal function. Previously, we have demonstrated that rats with decompensated CHF exhibited exaggerated sensitivity to the adverse renal effects of increased increased intraabdominal pressure (IAP) as compared with normal controls. This study tested whether phosphodiesterase 5 (PDE5) inhibition protects against the adverse renal effects of increased IAP in rats with CHF. Methods and resultsFollowing baseline periods, rats with compensated and decompensated CHF induced by the placement of an aorto-caval fistula (ACF), rats with myocardial infarction (MI) induced by left anterior descending (LAD) artery ligation, and sham controls were subjected to consecutive IAPs: 7, 10, or 14 mmHg. Urine flow (V), Na + excretion (U Na V), glomerular filtration rate (GFR), and renal plasma flow (RPF) were determined. The effects of pre-treatment with tadalafil on the adverse renal effects of IAP were examined in rats with decompensated CHF and MI. Elevation of IAP to 10 and 14 mmHg produced linear reductions in these parameters. Basal renal function and haemodynamics were lower in CHF rats. Decompensated CHF rats and MI rats that were subjected to 10 and 14 mmHg exhibited exaggerated declines in V, U Na V, GFR, and RPF. In contrast, no adverse renal effects were observed in rats with compensated CHF subjected to IAP. Pre-treatment of decompensated CHF rats and MI rats with tadalafil ameliorated the adverse renal effects of high IAP. ConclusionDecompensated CHF and MI rats are vulnerable to the adverse renal effects of IAP. Tadalafil abolishes IAP-induced renal dysfunction, supporting a therapeutic role for PDE5 inhibition in CHF associated with ascites.--

show abstract

Physiologic Considerations in Laparoscopic and Robotic Surgery

Kaplan¹,

Ferrandino²

2018

Smith's Textbook of Endourology

View full text Add to dashboard Cite

Pneumoperitoneum Aggravates Renal Function in Cases of Decompensated But Not Compensated Experimental Congestive Heart Failure: Role of Nitric Oxide

Abstract: Decompensated congestive heart failure renders rats susceptible to the adverse renal effects of pneumoperitoneum, a phenomenon that may involve alterations in the renal nitric oxide system.

Cited by 12 publications

References 27 publications

Effect of Pneumoperitoneum on Oxidative Stress and Inflammation via the Arginase Pathway in Rats

Effect of Pneumoperitoneum on Oxidative Stress and Inflammation via the Arginase Pathway in Rats

Phosphodiesterase 5 inhibition protects against increased intra‐abdominal pressure‐induced renal dysfunction in experimental congestive heart failure

Physiologic Considerations in Laparoscopic and Robotic Surgery

Contact Info

Product

Resources

About