Pneumonia can cause <sup>111</sup>Indium octreotide uptake

Yenson, Tam; Khalil, T; Larcos, George

doi:10.1111/j.1440-1673.2006.01565.x

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…Normal physiologic distribution of In-111 octreotide includes faint visualization of thyroid, pituitary gland and marked increased uptake in the liver, spleen, kidneys and bladder. Although rarely encountered, false-positive studies have been reported due to increased activity at nonmalignant pathologies such as Paget’s disease, parathyroid adenoma, cholecystitis, thrombus, abscess, infection, pulmonary fibrosis, pleural plaques and uterine myomas ( 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ). Only a few cases in the literature have reported increased In-111 octreotide activity in the gallbladder ( 10 , 11 , 12 , 13 , 14 ).…”

Section: Literature Review and Discussionmentioning

confidence: 99%

Visualization of Gallbladder with In-111 Octreotide Scan

Özülker

Özülker²,

Tatoğlu³

et al. 2015

Mirt

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A 54-year-old woman underwent octreotide scintigraphy for evaluation of neuroendocrine tumor recurrence. The images demonstrated unusual uptake in gallbladder area in addition to physiologic uptake at other tissues. Whole-body planar and SPECT imaging were repeated after fatty meal ingestion at 28 hours in order to figure out whether this activity was physiologic or not. Since the unusual uptake in the gallbladder was still detected at these images, additional images were obtained 72 hours after radionuclide injection. The activity in the gallbladder disappeared at these images revealing the physiologic nature of this unusual accumulation.

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Section: Literature Review and Discussionmentioning

confidence: 99%

Visualization of Gallbladder with In-111 Octreotide Scan

Özülker

Özülker²,

Tatoğlu³

et al. 2015

Mirt

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“…in their study have reported a case of an 18-year-old woman which underwent an 111 In octreotide scan for evaluation of a possible insulinoma. [8] Scan showed mildly increased radiopharmaceutical uptake involving the right lung base. On closer inquiry, the patient reported a productive cough for 5 days before the octreotide scan.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Patient was diagnosed with community-acquired pneumonia. [8] Uptake seen in inflammatory conditions is probably the result of tracer binding by somatostatin receptors on the inflammatory leukocytes Conclusions 111 Indium-pentetreotide scintigraphy improves tumor detection, has a major clinical significance and should be performed systematically for staging and to help in therapeutic decision in patients with NET. However, note should be made of false positive causes of uptake in this tracer for better interpretation of the scan.…”

Section: Discussionmentioning

confidence: 99%

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False-positive 111 In-pentetreotide Uptake in Gastritis

Usmani

Alshammari

2013

World J Nucl Med

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111In-pentetreotide [111In-octreoscan] is the most widely used radiolabeled somatostatin analog for evaluating neuroendocrine tumor overexpression of somatostatin receptors. False-positives studies of somatostatin receptor scintigraphy have been reported and often the cause is unexplained but assumed to be due to high number of somatostatin receptors in other pathologies. Causes of false-positives include visualization of the gallbladder, nasal mucosa and pulmonary hilar areas in respiratory infections, thyroid abnormalities, accessory spleens, recent Cerebrovascular accidents (CVA's) and activity at the site of a recent surgical incision. In infection or inflammation the cause of false-positive uptake is probably the result of tracer binding by somatostatin receptors on the inflammatory leukocytes. In this case report, we report, a 44-year-old male patient with false-positive 111In-pentetreotide uptake due to gastritis.

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“…The SSR-positive immune cell infiltration of lung parenchyma may cause an increased radioanalog uptake in pulmonary inflammations secondary to exposure to infectious agents and without granulomatous evolution as well (115,116). This last setting should be taken into consideration to avoid false positive interpretations when SRS is performed in the suspicion of non-infectious pulmonary diseases (17).…”

confidence: 99%

Somatostatin receptor scintigraphy in thoracic diseases

Ameri

Gatto

Arvigo

et al. 2007

J Endocrinol Invest

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Somatostatin (SS) receptor scintigraphy is useful for the diagnosis of lesions with high density of SS receptors, and above all neuroendocrine tumors. For several years, only indium-labeled octreotide has been applied to visualise in vivo tissues with SS receptor overexpression. Radiolabeled octreotide became the gold standard for the detection of neuroendocrine tumors. More recently, however, several new SS analogues with varying affinity for SS receptor subtypes have been developed, and different radionuclides as radiolabels have been introduced. Moreover, significant improvements have been made by the introduction of hybrid machines, such as single photon emission computed tomography/ computed tomography (SPECT/CT) or positron emission tomography (PET)/CT that enable to perform whole-body imaging quickly and with high anatomical resolution in several body areas, including the chest. The development of more specific radiopharmaceuticals, together with the modern technique of imaging, may provide excellent quality images with high contrast, allowing to depict very small lesions and making them easy to interpret. Indeed, in the management of SS receptor-positive lesions, the contribution of nuclear medicine is essential in several clinical settings, such as initial diagnosis, disease staging, follow-up, treatment planning, and treatment monitoring. In addition, the tracer uptake might be used as a prognostic parameter and as a predictor of treatment response. In the chest, apart in (neuro)endocrine tumors, SS receptors have been demonstrated in granulomatous diseases, like sarcoidosis and other immune-mediated disorders, such as anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis. In this paper we review and discuss the role of SS receptor scintigraphy in diagnosis, staging or follow- up of thoracic SS receptor-positive lesions.

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Pneumonia can cause ¹¹¹Indium octreotide uptake

Cited by 6 publications

References 9 publications

Visualization of Gallbladder with In-111 Octreotide Scan

Visualization of Gallbladder with In-111 Octreotide Scan

False-positive 111 In-pentetreotide Uptake in Gastritis

Somatostatin receptor scintigraphy in thoracic diseases

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Pneumonia can cause 111Indium octreotide uptake

Cited by 6 publications

References 9 publications

Visualization of Gallbladder with In-111 Octreotide Scan

Visualization of Gallbladder with In-111 Octreotide Scan

False-positive 111 In-pentetreotide Uptake in Gastritis

Somatostatin receptor scintigraphy in thoracic diseases

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Pneumonia can cause ¹¹¹Indium octreotide uptake