Pneumocystis carinii isolated from lung lavage fluid in an infant with cystic fibrosis

Prospective Multicenter Study of Pneumocystis jirovecii Colonization among Cystic Fibrosis Patients in France

“…Despite technical factors that can influence the reported prevalence of Pneumocystis colonization, and according to the abovecited studies (including our results), it appears that CF is associated with lower Pneumocystis colonization rates than are other chronic pulmonary diseases (14,20,22,24,26,27,32). Three studies have reported the association of P. jirovecii and P. aeruginosa in CF patients (14,22,25), but whether Pneumocystis infection/colonization complicated CF-associated lung disease remains unclear. In fact, little is known regarding the in vivo interactions between species, especially considering the bacterial and fungal community as a unique entity (lung microbiota) (8,11,31).…”

“…Several works support a significant association of P. jirovecii colonization with diverse chronic pulmonary diseases (6,12,21). Few severe PcP cases in cystic fibrosis (CF) patients have been reported (23,25), and only some studies have reported Pneumocystis carriage, the clinical significance of which remains practically unexplored (14,(18)(19)(20)(22)(23)(24)(25)(26). The aims of the present study were therefore to evaluate the prevalence of P. jirovecii colonization during a prospective multicenter observational study, to provide information regarding the distribution of Pneumocystis genotypes, and to explore the clinical relevance of Pneumocystis colonization among CF patients in France.…”

Pneumocystis jirovecii in Patients With Cystic Fibrosis: A Review

“…No additional data on genotypes in a context of primary infection in CF infants are available. Indeed, the two case reports on severe primary infection that we mentioned above did not provide any information about genotypes (Royce and Blumberg, 2000 ; Kaur et al, 2016 ). Conversely, data exist on genotypes in non-CF infants developing primary infection (Totet et al, 2003a , b ; Nevez et al, 2020 ).…”

“…Although rare, PCP can also occur contemporaneously to Pneumocystis primary infection in CF infants (Royce and Blumberg, 2000 ; Kaur et al, 2016 ) and the medical community should be aware of this. Early impairment of pulmonary function due to the genetic disease, in P. jirovecii immune-naïve infants, in the apparent absence of immunosuppression, could be the cause of PCP occurrence.…”

Managing Fungal Infections in Cystic Fibrosis Patients: Challenges in Clinical Practice

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