Pneumococcal vaccination during pregnancy for preventing infant infection

Safety of Inactivated Vaccines in Pregnancy

“…The results of a recent meta-analysis on the efficacy of Hemophilus influenzae b conjugate vaccines in children provide firm evidence of their effectiveness in reducing all forms of Hib invasive diseases [59]. Pneumococcal infections in young children can be also efficiently avoided by implementing infant immunization strategies [60] while a recent review concludes that there is insufficient evidence to support the use of Pneumococcal vaccination during pregnancy for preventing infant infections [61].…”

Safety of Inactivated Vaccines in Pregnancy

“…The results of a recent meta-analysis on the efficacy of Hemophilus influenzae b conjugate vaccines in children provide firm evidence of their effectiveness in reducing all forms of Hib invasive diseases [59]. Pneumococcal infections in young children can be also efficiently avoided by implementing infant immunization strategies [60] while a recent review concludes that there is insufficient evidence to support the use of Pneumococcal vaccination during pregnancy for preventing infant infections [61].…”

Pneumonia Vaccines: Indications for Use and Current Safety Data in Pregnancy

“…Evidence is conflicting regarding passive antibody levels in infants, with some studies demonstrating a high percentage of IgG reaching the infant and others showing minimal IgG passage. 42,44,58 The half-life of IgG against S. pneumoniae appears short, lasting 4 to 6 weeks, with rapid a decline to one-third the original concentration by 2 months of age. 42,59 Maternal pneumococcal vaccination does not reduce otitis media (RR: 0.88, 95% CI: 0.69-1.12) or lower respiratory tract infection (RR: 1.08, 95% CI: 0.82-1.43) in infants.…”

“…42,59 Maternal pneumococcal vaccination does not reduce otitis media (RR: 0.88, 95% CI: 0.69-1.12) or lower respiratory tract infection (RR: 1.08, 95% CI: 0.82-1.43) in infants. 58,60 Maternal pneumococcal vaccination in the third trimester and postpartum period increases breast milk IgA titers. [61][62][63] Among individuals immunized after delivery, rates of infant acute lower respiratory infection in the first 5 months of life were significantly lower compared with no maternal immunization (29.4 vs. 42.9%, p ¼ 0.003).…”

Vaccines and immunoglobulins

“…Pneumoccocal vaccination during pregnancy was proposed to be the way of preventing pneumococcal disease during the first month of life. However, experience with 280 pregnancies showed no evidence that pneumococcal vaccination during pregnancy reduces the risk of neonatal infection (Chaithongwongwatthana 2012). Mothers were vaccinated in the third trimester.…”

Safety of Inactivated Vaccines in Pregnancy

“…The results of a recent meta-analysis on the efficacy of Hemophilus influenzae b conjugate vaccines in children provide firm evidence of their effectiveness in reducing all forms of Hib invasive diseases [59]. Pneumococcal infections in young children can be also efficiently avoided by implementing infant immunization strategies [60] while a recent review concludes that there is insufficient evidence to support the use of Pneumococcal vaccination during pregnancy for preventing infant infections [61].…”

Pneumonia Vaccines: Indications for Use and Current Safety Data in Pregnancy

“…Evidence is conflicting regarding passive antibody levels in infants, with some studies demonstrating a high percentage of IgG reaching the infant and others showing minimal IgG passage. 42,44,58 The half-life of IgG against S. pneumoniae appears short, lasting 4 to 6 weeks, with rapid a decline to one-third the original concentration by 2 months of age. 42,59 Maternal pneumococcal vaccination does not reduce otitis media (RR: 0.88, 95% CI: 0.69-1.12) or lower respiratory tract infection (RR: 1.08, 95% CI: 0.82-1.43) in infants.…”

“…42,59 Maternal pneumococcal vaccination does not reduce otitis media (RR: 0.88, 95% CI: 0.69-1.12) or lower respiratory tract infection (RR: 1.08, 95% CI: 0.82-1.43) in infants. 58,60 Maternal pneumococcal vaccination in the third trimester and postpartum period increases breast milk IgA titers. [61][62][63] Among individuals immunized after delivery, rates of infant acute lower respiratory infection in the first 5 months of life were significantly lower compared with no maternal immunization (29.4 vs. 42.9%, p ¼ 0.003).…”

Vaccines and immunoglobulins

“…Pneumoccocal vaccination during pregnancy was proposed to be the way of preventing pneumococcal disease during the first month of life. However, experience with 280 pregnancies showed no evidence that pneumococcal vaccination during pregnancy reduces the risk of neonatal infection (Chaithongwongwatthana 2012). Mothers were vaccinated in the third trimester.…”

Safety of Inactivated Vaccines in Pregnancy

“…The results of a recent meta-analysis on the efficacy of Hemophilus influenzae b conjugate vaccines in children provide firm evidence of their effectiveness in reducing all forms of Hib invasive diseases [59]. Pneumococcal infections in young children can be also efficiently avoided by implementing infant immunization strategies [60] while a recent review concludes that there is insufficient evidence to support the use of Pneumococcal vaccination during pregnancy for preventing infant infections [61].…”

Pneumonia Vaccines: Indications for Use and Current Safety Data in Pregnancy

“…Evidence is conflicting regarding passive antibody levels in infants, with some studies demonstrating a high percentage of IgG reaching the infant and others showing minimal IgG passage. 42,44,58 The half-life of IgG against S. pneumoniae appears short, lasting 4 to 6 weeks, with rapid a decline to one-third the original concentration by 2 months of age. 42,59 Maternal pneumococcal vaccination does not reduce otitis media (RR: 0.88, 95% CI: 0.69-1.12) or lower respiratory tract infection (RR: 1.08, 95% CI: 0.82-1.43) in infants.…”

“…42,59 Maternal pneumococcal vaccination does not reduce otitis media (RR: 0.88, 95% CI: 0.69-1.12) or lower respiratory tract infection (RR: 1.08, 95% CI: 0.82-1.43) in infants. 58,60 Maternal pneumococcal vaccination in the third trimester and postpartum period increases breast milk IgA titers. [61][62][63] Among individuals immunized after delivery, rates of infant acute lower respiratory infection in the first 5 months of life were significantly lower compared with no maternal immunization (29.4 vs. 42.9%, p ¼ 0.003).…”

Vaccines and immunoglobulins

“…Pneumoccocal vaccination during pregnancy was proposed to be the way of preventing pneumococcal disease during the first month of life. However, experience with 280 pregnancies showed no evidence that pneumococcal vaccination during pregnancy reduces the risk of neonatal infection (Chaithongwongwatthana 2012). Mothers were vaccinated in the third trimester.…”