Pneumococcal Meningitis in Sickle Cell Disease in Childhood

Outcome of holistic care in Nigerian patients with sickle cell anaemia

“…It is conceivable that their addition to our regimen might have further improved the outcomes, particularly in the very young children who are the most susceptible to pneumococcal sepsis (Kabins & Lerner, 1970; Seeler, Metzger & Mufson, 1972). Although previous work had suggested that pneumococcal sepsis was relatively unimportant in children with sickle cell anemia in Africa (Akinyanju & Johnson, 1987; Akuse, 1996) this may be an artifact due to underreporting as other publications from the same continent had demonstrated the contrary (Eeckels, Gatti & Renoirte, 1967; Nottidge, 1983). Underreporting may arise from the fulminant course and rapid fatality of the infection (Hallock, David & Marshall, 1970; Kabins & Lerner, 1970; Seeler et al.…”

Global Case Fatality of Bacterial Meningitis During an 80-Year Period

“…We found additional studies specifically reporting on S pneumoniae (113 studies; 24 553 episodes) (eTable 8 in Supplement 1), N meningitidis (75 studies; 100 278 episodes) (eTable 9 in Supplement 1), H influenzae (49 studies; 28 796 episodes) (eTable 10 in Supplement 1), L monocytogenes (15 studies; 985 episodes) (eTable 11 in Supplement 1),…”

“…We found additional studies specifically reporting on S pneumoniae (113 studies; 24 553 episodes) (eTable 8 in Supplement 1 ), 394 , 395 , 396 , 397 , 398 , 399 , 400 , 401 , 402 , 403 , 404 , 405 , 406 , 407 , 408 , 409 , 410 , 411 , 412 , 413 , 414 , 415 , 416 , 417 , 418 , 419 , 420 , 421 , 422 , 423 , 424 , 425 , 426 , 427 , 428 , 429 , 430 , 431 , 432 , 433 , 434 , 435 , 436 , 437 , 438 , 439 , 440 , 441 , 442 , 443 , 444 , 445 , 446 , 447 , 448 , 449 , 450 ...…”

Infection and Potential Challenge of Childhood Mortality in Sickle Cell Disease: A Comprehensive Review of the Literature from a Global Perspective

“…Recently Chenou et al observed that SCD patients are 300 times more likely to develop bacterial meningitis than the normal population, and 10% of affected children die due to the infection generated by meningitis and pneumococcus [83]. Previous research found that meningitis in SCD patients caused by various bacteria, including H. influenzae, H. meningitis, and E. coli [84], and Streptococcus pneumonia, was responsible for 70% of bacterial meningitis cases in SCD children, while H. influenza was responsible for 80% [83,85]. The recurrence of meningitis occurs more frequently in SCD patients [86].…”