PLVAP is associated with glioma-associated malignant processes and immunosuppressive cell infiltration as a promising marker for prognosis

Ma, Kaiming; Chen, Xin; Zhao, Xianzhi; Chen, Suhua; Yang, Jun

doi:10.1016/j.heliyon.2022.e10298

Cited by 4 publications

(2 citation statements)

References 66 publications

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“…As reported, Plvap can promote angiogenesis in cholangiocarcinoma through the DKK1/CKAP4/PI3K pathway [ 22 ], and maintain the ultrastructure and function of chorionic capillaries in retinal ECs [ 23 ]. Moreover, Plvap plays a role in angiogenesis in liver cirrhosis [ 24 ], and is also considered to be a prognostic marker of glioma [ 25 ] and an early marker of glomerular endothelial injury in mice with diabetic kidney injury [ 26 ]. CYP4B1 can affect corneal inflammation and limbus vascular sprouting in rabbits [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation into the role of H2-Ab1 in vascular remodeling in pulmonary arterial hypertension via Bioinformatics

Wang,

Wang

2024

BMC Pulm Med

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Background Pulmonary arterial hypertension (PAH) is a progressive disease of vascular remodeling characterized by persistent pulmonary arterial pressure elevation, which can lead to right heart failure and premature death. Given the complex pathogenesis and poor prognosis of PAH, the identification and investigation of biomarkers become increasingly critical for advancing further understanding of the disease. Methods PAH-related datasets, GSE49114, GSE180169 and GSE154959, were downloaded from the publicly available GEO database. By performing WGCNA on the GSE49114 dataset, a total of 906 PAH-related key module genes were screened out. By carrying out differential analysis on the GSE180169 dataset, a total of 576 differentially expressed genes were identified. Additionally, the GSE154959 single-cell sequencing dataset was also subjected to differential analysis, leading to the identification of 34 DEGs within endothelial cells. By taking intersection of the above three groups of DEGs, five PAH-related hub genes were screened out, namely Plvap, Cyp4b1, Foxf1, H2-Ab1, and H2-Eb1, among which H2-Ab1 was selected for subsequent experiments. Results A SuHx mouse model was prepared using the SU5416/hypoxia method, and the successful construction of the model was evaluated through Hematoxylin-Eosin staining, hemodynamic detection, fulton index, and Western Blot (WB). The results of WB and qRT-PCR demonstrated a significant upregulation of H2-Ab1 expression in SuHx mice. Consistent with the results of bioinformatics analysis, a time-dependent increase was observed in H2-Ab1 expression in hypoxia-treated mouse pulmonary artery endothelial cells (PAECs). To investigate whether H2-Ab1 affects the development and progression of PAH, we knocked down H2-Ab1 expression in PAECs, and found that its knockdown inhibited the viability, adhesion, migration, and angiogenesis, while concurrently promoted the apoptosis of PAECs. Conclusion H2-Ab1 could regulate the proliferation, apoptosis, adhesion, migration, and angiogenesis of PAECs.

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Section: Discussionmentioning

confidence: 99%

Investigation into the role of H2-Ab1 in vascular remodeling in pulmonary arterial hypertension via Bioinformatics

Wang,

Wang

2024

BMC Pulm Med

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“…Meanwhile, APOBEC3D is also a tumor suppressor gene and promotes immune in ltration in breast cancer (BC) (24). PLVAP was markedly associated with immunosuppressive immune cell in ltration degrees and could be a promising target for glioma-based precise diagnosis and therapeutic strategies (25). Unfortunately, cg00229245, cg00678539, and cg11079619 hag have not been studied by the basic researcher.…”

Section: Discussionmentioning

confidence: 99%

Identification and Validation of a lipid metabolism-Immune-Based Prognostic Multiomics Signature for Oral Squamous Cell Carcinoma

Shi

Zhang

2022

Preprint

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Oral squamous cell carcinoma (OSCC) is one of the common oral cancers. This research is designed to establish a lipid metabolism-Immune-Based Prognostic Multiomics signature for OSCC and clarify the immune function, immune characteristics, the advantages of immune therapy, and pan-cancer analysis in the model-defined subgroups of OSCC. Based on lipid-metabolism-related genes and ESTIMATEScore, clustering analysis was applied to divide 373 OSCC samples into 21 high-immunity-lipid metabolism specimens and 172 low-immunity-lipid metabolism specimens. Through R packages “limma”, differential expression of mRNA, micro-RNA and DNA Methylation were identified. Then, the least absolute shrinkage and selection operator (LASSO) was applied to construct an 8-Multiomics Signature for predicting recurrence after surgery, and the risk model was validated in the TCGA-test and TCGA-train dataset. Afterward, the immune characteristics, immune function, and the advantages of ICI therapy in 8-Multiomics Signature subgroups were analyzed. Finally, the Pan-cancer analysis of eight symbols in the risk model was analyzed. In conclusion, 8-Multiomics Signature is a promising biomarker to distinguish the prognosis, the immune characteristics, and the immune benefit from immune therapy in OSCC.

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Expression analysis of plvap in mouse heart development, homeostasis and injury

Sui,

Kou,

et al. 2023

Gene Expression Patterns

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PLVAP is associated with glioma-associated malignant processes and immunosuppressive cell infiltration as a promising marker for prognosis

Cited by 4 publications

References 66 publications

Investigation into the role of H2-Ab1 in vascular remodeling in pulmonary arterial hypertension via Bioinformatics

Investigation into the role of H2-Ab1 in vascular remodeling in pulmonary arterial hypertension via Bioinformatics

Identification and Validation of a lipid metabolism-Immune-Based Prognostic Multiomics Signature for Oral Squamous Cell Carcinoma

Expression analysis of plvap in mouse heart development, homeostasis and injury

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