2016
DOI: 10.1038/srep20771
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: The etiology of atherosclerosis and restenosis involves aberrant inflammation and proliferation, rendering compounds with both anti-inflammatory and anti-mitogenic properties as promising candidates for combatting vascular diseases. A recent study identified the iridoid plumericin as a new scaffold inhibitor of the pro-inflammatory NF-κB pathway in endothelial cells. We here examined the impact of plumericin on the proliferation of primary vascular smooth muscle cells (VSMC). Plumericin inhibited serum-stimula… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
21
0

Year Published

2016
2016
2022
2022

Publication Types

Select...
8
2

Relationship

3
7

Authors

Journals

citations
Cited by 24 publications
(21 citation statements)
references
References 68 publications
0
21
0
Order By: Relevance
“…10 Preparations of the stem bark and latex of the Amazonian tree Himatanthus sucuuba (Spruce ex Müll.Arg.) Moreover, it has been shown to potentlynhibit the NF-κB pathway 15 and to possess antiproliferative properties in the vasculature 16 and it has been characterized as inhibitor of the TNF-α-induced senescence of endothelial cells. 11 The spirolactone iridoid plumericin, a major bioactive constituent of H. sucuuba, has been shown to exhibit antiparasitic, 12 antimicrobial, 13 and antifungal 14 activities.…”
Section: Introductionmentioning
confidence: 99%
“…10 Preparations of the stem bark and latex of the Amazonian tree Himatanthus sucuuba (Spruce ex Müll.Arg.) Moreover, it has been shown to potentlynhibit the NF-κB pathway 15 and to possess antiproliferative properties in the vasculature 16 and it has been characterized as inhibitor of the TNF-α-induced senescence of endothelial cells. 11 The spirolactone iridoid plumericin, a major bioactive constituent of H. sucuuba, has been shown to exhibit antiparasitic, 12 antimicrobial, 13 and antifungal 14 activities.…”
Section: Introductionmentioning
confidence: 99%
“…Plumericin was originally identified as an inhibitor of IKK234, but has recently been demonstrated to also deplete glutathione levels in smooth muscle cells, presumably due to its high thiol reactivity63. Depletion of glutathione has been shown to augment TNFα-induced ROS production in HUVECs6465.…”
Section: Discussionmentioning
confidence: 99%
“…The AngII, ET-1, AGE/RAGE and ROS pathways all culminate in increased NF-κB levels. In fact, NF-κB activation was shown to directly cause phenotype switching and increase of VSMC proliferation (97, 103-105). NF-κB also contributes to the disease progression by increasing expression of pro-inflammatory cytokines (TNF-α, IL-6, IL-8, IL-1) as well as cell adhesion molecules (ICAM-1 and VCAM-1) (106).…”
Section: Inflammationmentioning
confidence: 99%