Plexus and peripheral nerve metastasis

Gwathmey, Kelly

doi:10.1016/b978-0-12-811161-1.00017-7

Cited by 26 publications

(15 citation statements)

References 216 publications

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“…Acute plexopathy in the early phase of radiation therapy is also described, and they are often associated with pain. Rarely acute brachial plexopathy may be the manifestation of lymphoma infiltration or of neurolymphomatosis . Plexopathy in previously radiation‐treated lymphomas requires a thorough diagnostic assessment aiming at distinguishing tumor recurrence from post‐radiation myelopathy, which might exhibit the same clinical picture, although the first is generally more painful.…”

Section: Plexopathiesmentioning

confidence: 99%

“…Rarely acute brachial plexopathy may be the manifestation of lymphoma infiltration 82 or of neurolymphomatosis 83 . 84 Plexopathy in previously radiationtreated lymphomas requires a thorough diagnostic assessment aiming at distinguishing tumor recurrence from post-radiation myelopathy, which might exhibit the same clinical picture, although the first is generally more painful. Whereas solid tumor recurrence in plexi is often associated with Horner's syndrome, 85 this has rarely been described in lymphomas, generally secondary to bulky lymphadenopathy.…”

Section: Plexopathiesmentioning

confidence: 99%

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Peripheral nervous system involvement in lymphomas

Briani

Visentin

Campagnolo

et al. 2019

J Peripheral Nervous Sys

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The peripheral nervous system may be involved at any stage in the course of lymphoproliferative diseases. The different underlying mechanisms include neurotoxicity secondary to chemotherapy, direct nerve infiltration (neurolymphomatosis), infections, immune‐mediated, paraneoplastic or metabolic processes and nutritional deficiencies. Accordingly, the clinical features are heterogeneous and depend on the localization of the damage (ganglia, roots, plexi, and peripheral nerves) and on the involved structures (myelin, axon, and cell body). Some clinical findings, such a focal or diffuse involvement, symmetric or asymmetric pattern, presence of pain may point to the correct diagnosis. Besides a thorough medical history and neurological examination, neurophysiological studies, cerebrospinal fluid analysis, nerve biopsy (in selected patients with suspected lymphomatous infiltration) and neuroimaging techniques (magnetic resonance neurography and nerve ultrasound) may be crucial for a proper diagnostic workup.

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Section: Plexopathiesmentioning

confidence: 99%

Section: Plexopathiesmentioning

confidence: 99%

Peripheral nervous system involvement in lymphomas

Briani

Visentin

Campagnolo

et al. 2019

J Peripheral Nervous Sys

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“…бути наслідком прямої інвазії пухлиною периферичного нерва [15]. Класичним прикладом є злоякісна міжреберна нейропатія, яка ускладнює пухлину грудної стінки.…”

Section: хворобливі периферичні мононевропатії можутьunclassified

Chronic pain in cancer patients

Moisieienko

Марчук

Lisnyy

et al. 2022

PMJUA

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Background. Pain is a complex clinical sign that is highly variable in both intensity and perception by patients. Often, a combination of symptoms and signs can indicate a pain syndrome specific to oncology. Virtually all patients with malignant diseases experience recurrent episodes of acute pain, which may accompany previous surgery, invasive procedures, or complications such as pathologic fractures or disease progression. Chronic pain is a huge economic burden on society, both in terms of health care and lost productivity.Effective treatment of chronic pain results in significant improvements in general and psychological wellbeing and functioning of cancer patients and reduces the burden of chronic pain on health services.The purpose is to clarify the problems of the prevalence of chronic pain in cancer patients, the complexity and variability of the pathophysiological mechanisms of the development of pain syndrome, to consider modern approaches to the management of patients with chronic pain.Materials and methods. Modern foreign guidelines for the management of cancer patients with pain syndrome, written in English, data from metaanalyses, reviews and clinical studies were used.Conclusions. Data from a 2016 crosssectional study to determine the prevalence and impact of depression on health care costs in patients with complex chronic pain indicated that patients with chronic pain are at increased risk of developing depressive disorder of varying severity. About onethird of the study sample had major depression, and the overall prevalence of depression among individuals with chronic pain was higher than 50% [3].Up to 75% of all cancer patients with chronic pain have nociceptive (somatic or visceral) or neuropathic syndromes, which are a direct consequence of the development and progression of the neoplasm. Other causes include anticancer drugs and disorders unrelated to the disease or its treatment.Several systems are used to classify the pain syndrome, in particular — ECS-CP, IASP, ACTTION-APS.Today, in the management of cancer patients with chronic pain, the WHO threestep analgesic ladder is used: the first two steps are paracetamol and NSAIDs, mild opioids (control of mild and moderate pain), the third is opioids. The selection of opioids, their dosage and titration features should take into account the individual characteristics of the patient in order to avoid overdose and addiction.In addition to the abovementioned drugs, studies are being conducted to determine the effectiveness and feasibility of using medical cannabis as an alternative means, the use of which will improve the general condition of patients by relieving pain, and preventing the development of opioid addiction.Interventional techniques (neurolytic blockades, neuraxial infusions, trigger point injections, spinal cord stimulation, intrathecal drug administration, and vertebral augmentation) are also used to control chronic pain. The application of physical and psychosocial methods in the comprehensive management of such patients is studied.

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“…Pain over the shoulder girdles is a common initial presentation of metastatic brachial plexopathy. [1] Pain usually aggravates during shoulder motion due to the stretching of the nerves at the affected region, leading symptoms sometimes mimicking adhesive capsulitis. Weakness and sensory changes conventionally develop over the upper limb innervated by the lower trunk, but the deficit might be trivial at the early stage compared with the intense shoulder pain.…”

mentioning

confidence: 99%

“…The common cancers that incur metastatic brachial plexopathy comprise lung cancer, breast cancer, and lymphoma. [1] Therefore, in patients with the history of preexisting or on-going malignancy, detailed physical and imaging studies are required to investigate whether the shoulder pain results from metastatic lesions or tumor direct invasion.…”

mentioning

confidence: 99%

Ultrasound imaging for an uncommon cause of shoulder pain: Metastatic brachial plexopathy in a woman with breast cancer

Chang

2019

J Med Ultrasound

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Plexus and peripheral nerve metastasis

Cited by 26 publications

References 216 publications

Peripheral nervous system involvement in lymphomas

Peripheral nervous system involvement in lymphomas

Chronic pain in cancer patients

Ultrasound imaging for an uncommon cause of shoulder pain: Metastatic brachial plexopathy in a woman with breast cancer

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