Pleomorphic adenoma of the breast

Abstract

A clinicopathologic study of a pleomorphic adenoma of the breast is presented and attention is drawn to a previously unreported association with a cyst. Malignancy was strongly suspected in the light of radiologic features. Immunohistochemistry stresses the similarity between pleomorphic adenoma of salivary gland and breast. A common histogenesis of the two entities is also suggested. Ontogenetic links of both glands are mentioned.

Immunohistochemistry with keratin, vimentin, desmin, and α‐smooth muscle actin monoclonal antibodies in canine mammary gland: Benign mammary tumours and duct ectasias

“…As these cells were unreactive for a-actin, they have to be considered as entrapped epithelial remnants. Similar to observations in the benign canine mammary lesions, benign breast lesions in humans, e.g., intraductal papillomas, fibroadenomas and pleomorphic adenomas, contain elongated cells that are reactive with muscle-specific actin antibodies within the connective tissue of the tumours (4,39,43,44,53,63,66). Since actin antibodies also label myofibroblasts (25,52,53,56,62), and these stromal cells in the canine mammary lesions did not label with the keratin MoAbs known to label basal/myoepithelial cells, they may represent myofibroblasts rather than myoepithelial cells.…”

“…In myomost benign (complex) breast lesions in humans, epithelial cells are found as a single layer encircling duct or alveolar structures (12,20,43,49). Such cells express K 5, K 14 and K 17 (60).…”

Diagnosis of an extremely rare pleomorphic adenoma of the breast with core needle biopsy: A case report

“…It is recommended to perform a local resection with adequate margins of more than about 3mm cuff of normal tissue [ 2 , 20 ]. Damage to the capsule during surgical resection may lead to seeding of tumor cells, and multi-focal growth is sometimes recognized [ 14 , [16] , [17] , [18] , [19] , 21 , 22 ]. Since PAB frequently occurs in the periareolar region [ 12 , 13 ], a sufficient margin cannot be taken when nipple sparing surgery is performed, which is a risk factor for local recurrence.…”

Adenomyoepithelioma

“…Pleomorphic adenoma (Iyengar et al 2005;Narita and Matsuda 1995;Nevado et al 1991;Reid-Nicholson et al 2003) is composed by epithelial and myoepithelial cells and is frequently detected in subareolar location (Chen 1990). Usually, chondromyxoid changes are quite prominent and surely facilitate the correct diagnosis as these may only occasionally and focally be detected in AME.…”