Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects

Chen, Yan; Chen, Chen; Zhang, Xiaojuan; He, Chuanchuan; Zhao, Pengxuan; Li, Minsi; Fan, Ting; Yan, Ruicong; Lu, Yao; Lee, Robert J.; Khan, Muhammad Waseem; Sarfraz, Muhammad; Ma, Xiang; Tan, Yang; Xiang, Guangya

doi:10.1016/j.apsb.2019.10.011

Cited by 69 publications

(43 citation statements)

References 51 publications

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“…Chen and co-workers synthesized mPEG-PLGA nanoparticles via the nano-precipitation method for dual delivery of curcumin and cisplatin, using phenylboronate ester and disulphide bond as linkers [72]. The particle size analysis of polymeric nanoparticles using dynamic light scattering (DLS) displayed average particle diameters of 154.87 ± 10.32 nm, while the polymer index (PI) and zeta potential were 0.115 ± 0.012 and 20.8 ± 3.6 mV, respectively, demonstrating a good dispersion.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

“…In comparison with the excellent stability in storage, the drug release mechanism of the polymeric nanoparticles was high at 37 • C during dynamic dialysis, showing that it may be attributed to the temperature. MTT assay was performed on A549 cancer cells to study the cytotoxicity in vitro of the nanoparticles and the free drugs [72]. The dual drug-loaded nanoparticles exhibited high cytotoxicity which was 4-fold effective in cell growth inhibition when compared to the free curcumin on the A549 cancer cells.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

“…After injection of the mice with the formulation at a selected time duration of 1, 6, 12, and 24 h, respectively, the concentrations of the drugs in the tumor site were 1.45, 3.31, 2.61, and 0.93 μg/g, respectively, for the nanoparticles. The drug concentrations were higher for the nanoparticle formulation when compared to the free drug, which were 1.42, 1.25, 0.67 and 0.58 μg/g, respectively [ 72 ].…”

Section: Polymer-based Nanocarriers For Co-delivery Of Curcumin Wimentioning

confidence: 99%

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Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Alven

Aderibigbe

2020

Nanomaterials

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Cancer remains a heavy health burden resulting in a high rate of mortality around the world. The presently used anticancer drugs suffer from several shortcomings, such as drug toxicity, poor biodegradability and bioavailability, and poor water solubility and drug resistance. Cancer is treated effectively by combination therapy whereby two or more anticancer drugs are employed. Most of the combination chemotherapies result in a synergistic effect and overcome drug resistance. Furthermore, the design of polymer-based nanocarriers for combination therapy has been reported by several researchers to result in promising therapeutic outcomes in cancer treatment. Curcumin exhibits good anticancer activity but its poor bioavailability has resulted in its incorporation into several polymer-based nanocarriers resulting in good biological outcomes. Furthermore, the incorporation of curcumin together with other anticancer drugs have been reported to result in excellent therapeutic outcomes in vivo and in vitro. Due to the potential of polymer-based nanocarriers, this review article will be focused on the design of polymer-based nanocarriers loaded with curcumin together with other anticancer drugs.

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Section: Polymer-based Nanocarriers For Co-delivery Of Curcumin Wimentioning

confidence: 99%

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Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Alven

Aderibigbe

2020

Nanomaterials

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“…Approved: Nab-Paclitaxel Oral delivery not possible due to degradation in GI system, binding of active agents could lead to protein conformational changes [196] delivery platforms for co-formulating drugs [127]. Specifically, nano-encapsulation of Curcumin in liposomes and polymeric NPs has shown increased bioavailability that results in reduced inflammation and apoptotic effects for cancer cells [128,129]. Whereas the opposite event of an immuno-suppressed tumor environment stimulates cancer angiogenesis.…”

Section: Np-based Gi Carcinoma Therapiesmentioning

confidence: 99%

Nano drug delivery systems in upper gastrointestinal cancer therapy

et al. 2020

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Upper gastrointestinal (GI) carcinomas are characterized as one of the deadliest cancer types with the highest recurrence rates. Their treatment is challenging due to late diagnosis, early metastasis formation, resistance to systemic therapy and complicated surgeries performed in poorly accessible locations. Current cancer medication face deficiencies such as high toxicity and systemic side-effects due to the non-specific distribution of the drug agent. Nanomedicine has the potential to offer sophisticated therapeutic possibilities through adjusted delivery systems. This review aims to provide an overview of novel approaches and perspectives on nanoparticle (NP) drug delivery systems for gastrointestinal carcinomas. Present regimen for the treatment of upper GI carcinomas are described prior to detailing various NP drug delivery formulations and their current and potential role in GI cancer theranostics with a specific emphasis on targeted nanodelivery systems. To date, only a handful of NP systems have met the standard of care requirements for GI carcinoma patients. However, an increasing number of studies provide evidence supporting NP-based diagnostic and therapeutic tools. Future development and strategic use of NP-based drug formulations will be a hallmark in the treatment of various cancers. This article seeks to highlight the exciting potential of novel NPs for targeted cancer therapy in GI carcinomas and thus provide motivation for further research in this field.

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“…5,6 Retapamulin, another natural medicine derived from pleuromutilin produced by Pleurotus mutilus, an edible mushroom, is the first in a new class of antibacterial drugs known as pleuromutilins to be approved for use in humans. 7 In addition to the natural products that have been developed as commercial medications for humans, a number of them are on their way to be patented medicine, such as resveratrol, [8][9][10] curcumin, [11][12][13] oridonin, 14,15 etc. [16][17][18] However, developing a natural product-based new medicine from random moiety modification is a lengthy and costly process, due in part to the difficulties associated with comprehensively understanding their mechanism of action (MOA) as well as side effects.…”

Section: Introductionmentioning

confidence: 99%

Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification

Chen

Wang

et al. 2020

Sig Transduct Target Ther

120

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Natural products are an important source of new drugs for the treatment of various diseases. However, developing natural productbased new medicines through random moiety modification is a lengthy and costly process, due in part to the difficulties associated with comprehensively understanding the mechanism of action and the side effects. Identifying the protein targets of natural products is an effective strategy, but most medicines interact with multiple protein targets, which complicate this process. In recent years, an increasing number of researchers have begun to screen the target proteins of natural products with chemical proteomics approaches, which can provide a more comprehensive array of the protein targets of active small molecules in an unbiased manner. Typically, chemical proteomics experiments for target identification consist of two key steps: (1) chemical probe design and synthesis and (2) target fishing and identification. In recent decades, five different types of chemical proteomic probes and their respective target fishing methods have been developed to screen targets of molecules with different structures, and a variety of protein identification approaches have been invented. Presently, we will classify these chemical proteomics approaches, the application scopes and characteristics of the different types of chemical probes, the different protein identification methods, and the advantages and disadvantages of these strategies.

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Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects

Cited by 69 publications

References 51 publications

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Efficacy of Polymer-Based Nanocarriers for Co-Delivery of Curcumin and Selected Anticancer Drugs

Nano drug delivery systems in upper gastrointestinal cancer therapy

Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification

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