Platelet satellitism around lymphocytes: Case report and literature review

Lopez-Molina, Maria Isabel; Sorigué, Marc; Martínez-Iribarren, Alicia; E, Montero; Ganduxé, X. Tejedor; Leis, Alba; Sanjaume, Maria; Díaz, Maria-Antonia Llopis; Morales‐Indiano, Cristian

doi:10.1111/ijlh.12972

Cited by 7 publications

(4 citation statements)

References 9 publications

(10 reference statements)

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“…Although mostly platelet satellitism is observed due to the adhesion of the platelets to the neutrophils, multiple case reports describe the presence of platelet satellitism around other white blood cells including exclusively around lymphocytes as well as multilineage involvement with satellitism observed around neutrophils, monocytes as well as lymphocytes in patients with different underlying diagnoses [ 10 , 11 , 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Association of platelet satellitism with immune thrombocytopenia: A case report and review of literature

Wali,

Robinson,

Green

2024

eJHaem

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Platelet satellitism refers to the rosetting of the platelets around white blood cells, mostly neutrophils that could lead to spuriously low platelet counts on automated analyzers. The phenomenon has usually been described in EDTA processed blood samples. We describe the clinical course of a patient with immune thrombocytopenia with platelet satellitism in both EDTA as well as non EDTA processed blood samples. We also review the literature describing two other reports of the platelet satellitism in patients with immune thrombocytopenia. We also reference the literature describing the heterogeneity of the presence of platelet satellitism in different clinical and laboratory settings.

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Section: Discussionmentioning

confidence: 99%

Association of platelet satellitism with immune thrombocytopenia: A case report and review of literature

Wali,

Robinson,

Green

2024

eJHaem

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“…In a patient with positive pre-test score, the presence of anti-platelet factor 4 (PF4)/heparin antibodies should be confirmed by a functional assay, which measures heparin-dependent platelet activation/aggregation induced by HIT antibodies [138]. Finally, a B-cell lymphoproliferative disorder could be suspected in the presence of platelet satellitism around lymphocytes [63].…”

Section: Discussionmentioning

confidence: 99%

“…Spurious thrombocytopenia could also be related to platelet satellitism around white blood cells. Classically observed as an in vitro phenomenon with platelet rosetting around the cytoplasm of neutrophils, it has been less frequently observed around lymphocytes [7,63]. The underlying mechanism has not been fully elucidated so far, though IgG autoantibodies targeting GpIIbIIIa would be involved in binding to neutrophil Fc Gamma receptor [64].…”

Section: Mechanisms Prevalence and Risk Factors 31 Mechanismsmentioning

confidence: 99%

Pseudothrombocytopenia—A Review on Causes, Occurrence and Clinical Implications

Lardinois

Favresse

Châtelain

et al. 2021

JCM

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Pseudothrombocytopenia (PTCP), a relative common finding in clinical laboratories, can lead to diagnostic errors, overtreatment, and further (even invasive) unnecessary testing. Clinical consequences with potential life-threatening events (e.g., unnecessary platelet transfusion, inappropriate treatment including splenectomy or corticosteroids) are still observed when PTCP is not readily detected. The phenomenon is even more complex when occurring with different anticoagulants. In this review we present a case of multi-anticoagulant PTCP, where we studied different parameters including temperature, amikacin supplementation, measurement methods, and type of anticoagulant. Prevalence, clinical risk factors, pre-analytical and analytical factors, along with clinical implications, will be discussed. The detection of an anticoagulant-dependent PTCP does not necessarily imply the presence of specific disorders. Conversely, the incidence of PTCP seems higher in patients receiving low molecular weight heparin, during hospitalization, or in men aged 50 years or older. New analytical technologies, such as fluorescence or optical platelet counting, will be soon overturning traditional algorithms and represent valuable diagnostic aids. A practical laboratory approach, based on current knowledge of PTCP, is finally proposed for overcoming spuriously low platelet counts.

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“…Criswell, et al [9] reported that in the case of PS, the "greatest clinical relevance is spurious reporting that can lead to unnecessary treatment of thrombocytopenia"; however, the involvement of atypical lymphocytes in most cases of lymphoid neoplasms should be considered a potential non-casual association. Therefore, the recommendation to check platelet counts while simultaneously evaluating for a possible lymphoproliferative disorder is entirely acceptable in cases of PS involving lymphocytes [10].…”

mentioning

confidence: 99%