Platelet-rich plasma (PRP) enhances bone healing in non-united critical-sized defects: A preliminary study involving rabbit models

Kanthan, S. R.; Kavitha, G; Addi, S.; Choon, David; Kamarul, Tunku

doi:10.1016/j.injury.2011.01.015

Cited by 78 publications

(71 citation statements)

References 26 publications

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“…One such in vivo study conducted by Kanthan et al demonstrated that the best bone healing based on radiological, histological, and gross findings, occurred in the platelet gel combined with artificial bone (Coragraft) group. Figure 2 grossly depicts rabbit tibia healing over 11 weeks which ultimately demonstrates that the independent use of the platelet gel or synthetic bone alone does not promote adequate bone repair [74]. …”

Section: Gelsmentioning

confidence: 99%

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Platelet-Rich Plasma in Bone Regeneration: Engineering the Delivery for Improved Clinical Efficacy

Rodriguez

Kalaf

Bowlin

et al. 2014

BioMed Research International

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Human bone is a tissue with a fairly remarkable inherent capacity for regeneration; however, this regenerative capacity has its limitations, and defects larger than a critical size lack the ability to spontaneously heal. As such, the development and clinical translation of effective bone regeneration modalities are paramount. One regenerative medicine approach that is beginning to gain momentum in the clinical setting is the use of platelet-rich plasma (PRP). PRP therapy is essentially a method for concentrating platelets and their intrinsic growth factors to stimulate and accelerate a healing response. While PRP has shown some efficacy in both in vitro and in vivo scenarios, to date its use and delivery have not been optimized for bone regeneration. Issues remain with the effective delivery of the platelet-derived growth factors to a localized site of injury, the activation and temporal release of the growth factors, and the rate of growth factor clearance. This review will briefly describe the physiological principles behind PRP use and then discuss how engineering its method of delivery may ultimately impact its ability to successfully translate to widespread clinical use.

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Section: Gelsmentioning

confidence: 99%

“…Gross examination of rabbit tibia healing after 11 weeks with (a) control group, no platelet gel or Coragraft; (b) platelet gel; (c) Coragraft; and (d) platelet gel and Coragraft [74]. Reprinted with permission from Elsevier.…”

Section: Figurementioning

confidence: 99%

Platelet-Rich Plasma in Bone Regeneration: Engineering the Delivery for Improved Clinical Efficacy

Rodriguez

Kalaf

Bowlin

et al. 2014

BioMed Research International

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“…However, these effects were dependent on the PRP composition [10]. Somehow data become controversial when in vivo settings are compared, since opposite outcomes are equally available in the scientific literature in favor [11][12][13][14][15][16][17][18][19][20][21] or against [19,[22][23][24][25][26][27] the addition of PRP to biologic and synthetic graft materials for bone regeneration purposes. Interestingly, the association of PRP with mesenchymal stem cells showed mostly satisfying results [28,29] in the field.…”

Section: Introductionmentioning

confidence: 99%

Cytokine, chemokine, and growth factor profile of platelet-rich plasma

et al. 2016

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During wound healing, biologically active molecules are released from platelets. The rationale of using platelet-rich plasma (PRP) relies on the concentration of bioactive molecules and subsequent delivery to healing sites. These bioactive molecules have been seldom simultaneously quantified within the same PRP preparation. In the present study, the flexible Bio-Plex system was employed to assess the concentration of a large range of cytokines, chemokines, and growth factors in 16 healthy volunteers so as to determine whether significant baseline differences may be found. Besides IL-1b, IL-1ra, IL-4, IL-6, IL-8, IL-12, IL-13, IL-17, INF-γ, TNF-α, MCP-1, MIP-1a, RANTES, bFGF, PDGF, and VEGF that were already quantified elsewhere, the authors reported also on the presence of IL-2, IL-5, IL-7, IL-9, IL-10, IL-15 G-CSF, GM-CSF, Eotaxin, CXCL10 chemokine (IP-10), and MIP 1b. Among the most interesting results, it is convenient to mention the high concentrations of the HIV-suppressive and inflammatory cytokine RANTES and a statistically significant difference between males and females in the content of PDGF-BB. These data are consistent with previous reports pointing out that gender, diet, and test system affect the results of platelet function in healthy subjects, but seem contradictory when compared to other quantification assays in serum and plasma. The inconsistencies affecting the experimental results found in literature, along with the variability found in the content of bioactive molecules, urge further research, hopefully in form of randomized controlled clinical trials, in order to find definitive evidence of the efficacy of PRP treatment in various pathologic and regenerative conditions.

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“…Although the disputes about the increased prevalence of PRP therapy always exist, some authors [5] have claimed a theoretical basis for the prevalence. In the last few years, PRP has been applied as a means to facilitate the healing process in fields such as bone injuries [6–9], chondrogenesis [10], chondral defects [11], reduction of bone resorption [12], cruciate ligament repair [13,14], chronic elbow tendinosis [15], Achilles tendinopathy [16], rotator cuff repair [17,18], jumper’s knee [19], chronic soft lesion [20], cardiac disease [21], dentistry, and maxillofacial surgery [22]. Although some studies have shown that platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis can promote osteoarthritic cartilage healing, better results were achieved in younger patients with a low degree of cartilage degeneration [23–25].…”

Section: Introductionmentioning

confidence: 99%

A novel hypothesis: The application of platelet-rich plasma can promote the clinical healing of white-white meniscal tears

Wei

Gao

et al. 2012

Med Sci Monit

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SummaryThe white-white tears (meniscus lesion completely in the avascular zone) are without blood supply and theoretically cannot heal. Basal research has demonstrated that menisci are unquestionably important in load bearing, load redistribution, shock absorption, joint lubrication and the stabilization of the knee joint. It has been proven that partial or all-meniscusectomy results in an accelerated degeneration of cartilage and an increased rate of early osteoarthritis. Knee surgeons must face the difficult decision of removing or, if possible, retaining the meniscus; if it is possible to retain the meniscus, surgeons must address the difficulties of meniscal healing. Some preliminary approaches have progressed to improve meniscal healing. However, the problem of promoting meniscal healing in the avascular area has not yet been resolved. The demanding nature of the approach as well as its low utility and efficacy has impeded the progress of these enhancement techniques. Platelet-rich plasma (PRP) is a platelet concentration derived from autologous blood. In recent years, PRP has been used widely in preclinical and clinical applications for bone regeneration and wound healing. Therefore, we hypothesize that the application of platelet-rich plasma for white-white meniscal tears will be a simple and novel technique of high utility in knee surgery.

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Platelet-rich plasma (PRP) enhances bone healing in non-united critical-sized defects: A preliminary study involving rabbit models

Cited by 78 publications

References 26 publications

Platelet-Rich Plasma in Bone Regeneration: Engineering the Delivery for Improved Clinical Efficacy

Platelet-Rich Plasma in Bone Regeneration: Engineering the Delivery for Improved Clinical Efficacy

Cytokine, chemokine, and growth factor profile of platelet-rich plasma

A novel hypothesis: The application of platelet-rich plasma can promote the clinical healing of white-white meniscal tears

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