Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution

Dohan, D.; Choukroun, Joseph; Diss, Antoine; Dohan, S.; Dohan, Anthony; Mouhyi, Jaafar; Gogly, Bruno

doi:10.1016/j.tripleo.2005.07.008

Cited by 1,423 publications

(1,544 citation statements)

References 61 publications

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“…27 PRF clots were easily separated from red corpuscles base by using sterile tweezers and scissors and then transformed into fibrin membranes by using the PRF Box (Process, Nice, France), designed to collect and standardise PRF clots and membranes in order to avoid extracting and losing a significant amount of growth factors. 28 One PRF was cut by scissors to produce small pieces and then mixed with ABBM granules with a particle size of 0.25-1 mm (Bio-Oss, Gesitlich, Switzerland) in a sterile dappen dish; this mixture was added to the defect by means of a sterile curette.…”

Section: Surgical Therapymentioning

confidence: 99%

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Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

et al. 2017

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Anorganic bovine bone mineral (ABBM) is extensively used in the treatment of intra-bony defects. Platelet-rich fibrin (PRF) is a new-generation platelet concentrate with a simplified technique. Although certain studies have reported the use of PRF in the treatment of intra-bony defects, to date, none of them have evaluated its additive effects with ABBM. Therefore, a randomised, split-mouth clinical trial was conducted to compare healing of intra-bony defects treated with an ABBM-PRF combination with healing of those treated with ABBM alone. By using a split-mouth design, 15 paired intra-bony defects were randomly treated with either ABBM alone (control group) or ABBM-PRF combination (test group). Following clinical parameters and radiographical measurements were recorded at baseline and 6 months after treatment: plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), clinical attachment level (CAL), vertical bone loss, depth of defect and defect angle. Preoperative clinical and radiographical measurements were similar for the test and control groups. Statistically significant reductions in GI, PD, CAL, vertical bone loss, depth of intra-bony defect and widening of defect angle were detected after treatment in both groups. With respect to inter-group analysis, gain in CAL was significantly greater in the test group than in the control group, whereas no inter-group differences were observed in any other parameter. The results of this study indicate that both therapies are effective in the treatment of intra-bony defects.

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Section: Surgical Therapymentioning

confidence: 99%

“…28 Both obtaining and compression methods influence the total amount and releasing profile of growth factors in PRF. 27,28 Therefore, following Choukroun's simple protocol principles is necessary to obtain reproducible and reliable results. However, our study also has certain limitations.…”

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confidence: 99%

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

et al. 2017

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“…Platelet rich fibrin belongs to a next generation of platelet concentrate geared to simplified preparation without biochemical blood handling [3]. Platelet rich fibrin has come up as second generation platelet concentrate with cicatricial properties.…”

Section: Introductionmentioning

confidence: 99%

Platelet Rich Fibrin: A Novel Approach for Osseous Regeneration

Singh

Kohli

Gupta

2012

J. Maxillofac. Oral Surg.

117

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“…Platelet-rich fibrin (PRF) represents a new step in the platelet gel therapeutic concept with simplified processing without artificial biochemical modification. Unlike other platelet concentrates, this technique requires neither anticoagulants nor bovine thrombin nor any other gelifying agent making it no more than centrifuged natural blood without additives [20] The real therapeutic potential of PRF lies in Platelet alpha (α) granules form an intracellular storage pool of growth factors (GF) including platelet-derived growth factor (PDGF), transforming growth factor β (TGF-β, including β-1 and β-2-isomers), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF).7 Insulin-like growth factor-1 which accelerate rate of healing [21].…”

Section: Discussionmentioning

confidence: 99%

Apexification of Immature Teeth Using Novel Apical Matrices and MTA Barrier: Report of Two Cases

Ahire¹,

Pathak²,

Dekate³

2014

IOSRJDMS

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Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution

Cited by 1,423 publications

References 61 publications

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

Platelet Rich Fibrin: A Novel Approach for Osseous Regeneration

Apexification of Immature Teeth Using Novel Apical Matrices and MTA Barrier: Report of Two Cases

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