Platelet Monoamine Oxidase B Activity as a State Marker for Alcoholism: Trend Over Time During Withdrawal and Influence of Smoking and Gender

Coccini, Teresa; Castoldi, Anna Federica; Gandini, C.; Randine, Giovanna; Vittadini, G; Baiardi, Paola; Manzo, Luigi

doi:10.1093/alcalc/37.6.566

Cited by 24 publications

(16 citation statements)

References 45 publications

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“…Others (Takahashi et al, 1976;Brown, 1977) reported that the low platelet MAO activity returned to normal levels after episodes of alcoholism had subsided. As observed in smoking cessation, the activity of MAO in platelets of alcohol-dependent subjects (type of alcoholism was not further specified) increased by 40% after 8 days of alcohol withdrawal, and attained control values that remained stable thereafter (15 to 22 days of abstinence) (Coccini et al, 2002). This temporal pattern remained after correction for smoking and gender.…”

Section: Mao and Withdrawal From Alcoholmentioning

confidence: 71%

Contribution of monoamine oxidase (MAO) inhibition to tobacco and alcohol addiction

et al. 2006

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Section: Mao and Withdrawal From Alcoholmentioning

confidence: 71%

Contribution of monoamine oxidase (MAO) inhibition to tobacco and alcohol addiction

et al. 2006

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“…The premise is sufficiently established to allow a platelet protein biochip, developed for detection of an Alzheimer's disease-specific phenotype, to include MAO B (Veitinger et al, 2014a, Veitinger et al, 2014b. This technical advance in diagnosis could be expanded for other neuropathologies or behavior with known associations to MAO B, for example, alcoholism (Coccini et al, 2002).…”

Section: Expressed Protein Levelsmentioning

confidence: 99%

Molecular aspects of monoamine oxidase B

Ramsay

2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Graphical abstract Highlights• MAO B activity depends on both amine and oxygen concentrations KeywordsMonoamine oxidase B; kinetics; drug design; neurotransmitter levels; platelet AbbreviationsAlzheimer's Disease, AD; Parkinson's Disease, PD; dopamine transporter, DAT; serotonin transporter, SERT; noradrenaline transporter, NET; the vesicular transporter, VMAT; Gprotein coupled receptor, GPCR; induced pluripotent stem cells, iPSC; serotonin reuptake inhibitor, SSRI; brain-derived neurotrophic factor, BDNF; multi-target designed ligands, MTDL; IC 50 , the concentration of compound required to inhibit a specified assay by 50%; K i , a kinetically measured inhibitor dissociation constant. Word count -approx 5490 (excluding references). Abstract 196 words.3

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“…Having in mind a number of factors that could influence MAO activity, such large interstudy variability may reflect certain methodological biases. For example, an increase in MAO activity a week after withdrawal (in fact -a return to the normal values) reported by Coccini et al [40] , may be due to higher leukocyte contamination of alcoholic plasma samples (MAO activity in that study was related to the protein content; see discussion on this issue bellow), inadequate adjusting for smoking (not recorded in the control group), gender (disproportionate representation among groups), or something else. In a recent review of the subject [36] , the need to study the effect of alcohol withdrawal on MAO-B activity in type 2 alcoholics that were controlled for smoking was emphasized.…”

Section: Discussionmentioning

confidence: 79%

Platelet Monoamine Oxidase Kinetics, Alcoholism Subtypes and Cigarette Smoking

et al. 2007

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In trying to dissociate the effect of alcohol and tobacco use on platelet monoamine oxidase-B (MAO-B) activity, we compared the enzyme kinetics in controls (n = 66) and alcohol-dependent patients (n = 81), subdivided according to the severity of both, alcohol and tobacco use. Platelet MAO-B kinetics was measured spectrophotofluorimetrically in chronic alcohol intoxication and after 3 weeks abstinence. In alcoholic patients, an increased Michaelis-Menten constant (16%, p < 0.01) was shown, notwithstanding smoking status. Maximal velocity did not differ between patients and controls when adjusted for smoking. In cigarette smokers, a highly significant dose-dependent reduction of platelet MAO velocity (40%, p < 0.001) was demonstrated, with a similar degree of reduction in patients and controls. Tobacco use itself had no influence on MAO affinity. No differences were shown between subtype 1 and 2 alcoholics, or between the day of admission and the 21st day of abstinence. In conclusion, it seems that both, alcohol and tobacco consumption, may contribute to the lowering of overall platelet MAO-B activity. The effect of alcohol is small, due to interference with substrate binding, and not alteration of catalytic activity. In contrast, the effect of cigarette smoking is pronounced and relates to the dose-dependent reduction of platelet MAO velocity, with no influence on its affinity.

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Platelet Monoamine Oxidase B Activity as a State Marker for Alcoholism: Trend Over Time During Withdrawal and Influence of Smoking and Gender

Abstract: MAO-B can be regarded as a state marker of alcohol consumption. The temporal pattern of platelet MAO-B activity may be used for the diagnostic assessment of alcoholism and early abstinence, regardless of gender and smoking status.

Cited by 24 publications

References 45 publications

Contribution of monoamine oxidase (MAO) inhibition to tobacco and alcohol addiction

Contribution of monoamine oxidase (MAO) inhibition to tobacco and alcohol addiction

Molecular aspects of monoamine oxidase B

Platelet Monoamine Oxidase Kinetics, Alcoholism Subtypes and Cigarette Smoking

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