Platelet Lysate: A Promising Candidate in Regenerative Medicine

Abstract

Human platelet lysate has attracted much interest from many researchers as it is growth-factor rich for cell expansion, which is employed as a new therapeutic strategy. Not only are human platelet lysates used for cell therapy, but they are also used for the completion of basal media in mesenchymal stem cell cultures. Due to the presence of a large number of growth factors, platelet lysates have potential roles in wound healing, treatment of ocular graft-versus-host disease, osteoarthritis, Parkinson’s disease, tendon regeneration, infertility, androgenetic alopecia, nerve repair and regenerative tissue, such as bone regeneration. In this review, we summarize that platelet lysates could be valuable candidates for the treatment of a variety of diseases in regenerative medicine.

A Kinetic Stem Cell Counting Analysis of the Specific Effects of Cell Culture Medium Growth Factors on Adipose-Derived Mesenchymal Stem Cells

“…This report details a study designed to evaluate four commercial supplements widely used for expanding MSCs. Although presumed to have effects on the viability or proliferation of stem cells in MSC-containing cell cultures, such specific effects had not been confirmed previously [ 11 , 12 , 13 , 14 ].…”

Bone-targeting delivery of platelet lysate exosomes ameliorates glucocorticoid-induced osteoporosis by enhancing bone-vessel coupling

“…PL as the second generation of PRP, is a cost-effective substitute of commercial recombined GFs, presenting broader application prospects [ 43 ]. In addition to replacing fetal bovine serum for the expansion of MSCs in vitro, PL accelerates bone repair in vivo by promoting osteogenesis and angiogenesis.…”

Evaluation of the Regenerative Potential of Platelet-Lysate and Platelet-Poor Plasma Derived from the Cord Blood Units in Corneal Wound Healing Applications: An In Vitro Comparative Study on Corneal Epithelial Cells

“…The application of specific blood derivatives such as the PL and PPP in wound healing applications has attracted the attention of the scientific community and could be considered as potential substitutes for the gold standard method (artificial tear drops, lubricants, and immunosuppressor eye drops) daily, worldwide [ 35 ]. PL and PPP, due to their regenerative potential mediated by the exerted biomolecule content, can share key therapeutic effects in different fields of medicine [ 36 ].…”