Platelet hemostasis in patients with metabolic syndrome and type 2 diabetes mellitus: cGMP- and NO-dependent mechanisms in the insulin-mediated platelet aggregation

Суслова, Т. Е.; Ситожевский, А. В.; Ogurkova, O. N.; Kravchenko, Elena S.; Кологривова, И. В.; Anfinogenova, Yana; Карпов, Р. С.

doi:10.3389/fphys.2014.00501

Cited by 58 publications

(48 citation statements)

References 54 publications

(94 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the MPV was correlated with the systolic blood pressure, BMI, and ic factors in comparison with individuals that do not have DM 23,24 . Patients with type 2 DM have a higher risk of coagulation abnormalities and thromboembolic events 25,26 . Inflammation, oxidative stress, a reduction in the calcium metabolism and in nitric oxide bioavailability, an increase in phosphorylation and glycosylation of cell proteins are all factors responsible for the increase in platelet activation and release of prothrombotic agents 22 .…”

Section: Pvi and Hypertensionmentioning

confidence: 99%

Platelets volume indexes and cardiovascular risk factors

Batista

Figueiredo

Rios

2018

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

SUMMARY Obesity, diabetes and hypertension are risk factors for cardiovascular diseases (CVD) because they promote a state of hypercoagulability. It is known that platelets play an important role in the development of atherosclerosis. Recent studies have evaluated platelet volume indexes (PVIs) in individuals with risk factors for CVD to better understand the platelet mechanisms involved in their development. The IVPs indirectly estimate platelet function and are easily obtained from automated hematology analyzers, which provide platelet counts, mean platelet volume (MPV), platelet distribution width (PDW) and the platelet-large cell ratio (P-LCR). The present study aims to review literature studies that investigated the association between PVIs and obesity, diabetes, and arterial hypertension, in order to evaluate its use as a potential subclinical marker of CVD. Studies have shown promising results for MPV, an index that allows for early detection of platelet activation and may be useful in identifying patients before the onset of CVD development so that preventive strategies can be implemented. The PDW, although evaluated by a smaller number of studies, also showed promising results. However, there is still a long way to go in order for the MPV and PDW to be used in clinical practice, since there is still a need for more epidemiological evidence, establishing reference values, and standardizing the way results are presented.

show abstract

Section: Pvi and Hypertensionmentioning

confidence: 99%

Platelets volume indexes and cardiovascular risk factors

Batista

Figueiredo

Rios

2018

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

show abstract

“…Patients with type 2 diabetes mellitus (T2DM) have been reported to have an elevated risk of coagulation abnormalities and thromboembolic episodes. Platelets have a main function and increased adhesion, activation and aggregation of platelets due to dysregulation of several signaling pathways and metabolic alterations including insulin resistance, hyperglycaemia and dyslipidaemia have been shown in gestational diabetic patients [4]. Systemic inflammation, oxidative stress, impaired calcium metabolism, reduced bioavailability of nitric oxide, raised phosphosrylation and glycosylation of cellular proteins are involved in increased platelet activation and raised release of prothrombotic and proinflammatory agents in gestational diabetes [5].…”

Section: Haematological Findings In Gestational Diabetesmentioning

confidence: 99%

Gestational Diabetes: Haematological Perspective

Ifeanyi¹,

Uzoma²,

N³

2019

SARJAMS

View full text Add to dashboard Cite

Gestational diabetes is a carbohydrate intolerance of variable severity with onset or first recognition during pregnancy. It occurs in all ages but more pronounced among the aging pregnant women. Haematological parameters have been reported as good markers to monitor the gestational diabetes patients. Careful haematological investigations will help to improve the wellbeing of the affected patients and prevent it as predictors of the severity of the disease. This paper was written to enhance the knowledge of the society on this incident that happens to a lot of pregnant women if not monitored may precipitate so many damages in the systems and organs of the pregnant women.

show abstract

“…Loss of such bioactivity also appears to contribute to diabetic cardiomyopathy and platelet hyperaggregabilty [41,42]. …”

Section: Nadph Oxidase Uncoupled Enos and Decreased No Bioactivimentioning

confidence: 99%

Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin—Potential for Preventing or Slowing the Progression of Diabetic Complications

McCarty

2017

Healthcare

View full text Add to dashboard Cite

Oxidative stress, the resulting uncoupling of endothelial nitric oxide synthase (eNOS), and loss of nitric oxide (NO) bioactivity, are key mediators of the vascular and microvascular complications of diabetes. Much of this oxidative stress arises from up-regulated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. Phycocyanobilin (PhyCB), the light-harvesting chromophore in edible cyanobacteria such as spirulina, is a biliverdin derivative that shares the ability of free bilirubin to inhibit certain isoforms of NADPH oxidase. Epidemiological studies reveal that diabetics with relatively elevated serum bilirubin are less likely to develop coronary disease or microvascular complications; this may reflect the ability of bilirubin to ward off these complications via inhibition of NADPH oxidase. Oral PhyCB may likewise have potential in this regard, and has been shown to protect diabetic mice from glomerulosclerosis. With respect to oxidant-mediated uncoupling of eNOS, high-dose folate can help to reverse this by modulating the oxidation status of the eNOS cofactor tetrahydrobiopterin (BH4). Oxidation of BH4 yields dihydrobiopterin (BH2), which competes with BH4 for binding to eNOS and promotes its uncoupling. The reduced intracellular metabolites of folate have versatile oxidant-scavenging activity that can prevent oxidation of BH4; concurrently, these metabolites promote induction of dihydrofolate reductase, which functions to reconvert BH2 to BH4, and hence alleviate the uncoupling of eNOS. The arginine metabolite asymmetric dimethylarginine (ADMA), typically elevated in diabetics, also uncouples eNOS by competitively inhibiting binding of arginine to eNOS; this effect is exacerbated by the increased expression of arginase that accompanies diabetes. These effects can be countered via supplementation with citrulline, which efficiently enhances tissue levels of arginine. With respect to the loss of NO bioactivity that contributes to diabetic complications, high dose biotin has the potential to “pinch hit” for diminished NO by direct activation of soluble guanylate cyclase (sGC). High-dose biotin also may aid glycemic control via modulatory effects on enzyme induction in hepatocytes and pancreatic beta cells. Taurine, which suppresses diabetic complications in rodents, has the potential to reverse the inactivating impact of oxidative stress on sGC by boosting synthesis of hydrogen sulfide. Hence, it is proposed that concurrent administration of PhyCB, citrulline, taurine, and supranutritional doses of folate and biotin may have considerable potential for prevention and control of diabetic complications. Such a regimen could also be complemented with antioxidants such as lipoic acid, N-acetylcysteine, and melatonin—that boost cellular expression of antioxidant enzymes and glutathione—as well as astaxanthin, zinc, and glycine. The development of appropriate functional foods might make it feasible for patients to use complex nutraceutical regimens of the sort suggested here.

show abstract

Platelet hemostasis in patients with metabolic syndrome and type 2 diabetes mellitus: cGMP- and NO-dependent mechanisms in the insulin-mediated platelet aggregation

Cited by 58 publications

References 54 publications

Platelets volume indexes and cardiovascular risk factors

Platelets volume indexes and cardiovascular risk factors

Gestational Diabetes: Haematological Perspective

Supplementation with Phycocyanobilin, Citrulline, Taurine, and Supranutritional Doses of Folic Acid and Biotin—Potential for Preventing or Slowing the Progression of Diabetic Complications

Contact Info

Product

Resources

About