Platelet-Derived Growth Factor Is Chemotactic for Human Retinal Pigment Epithelial Cells

Expression of PDGFRα Is a Determinant of the PVR Potential of ARPE19 Cells

“…We considered PDGFR␣ a mediator of PVR because PDGFR␣ potently enhances the PVR potential of fibroblasts. 14,28 Consistent with previous studies using RPE cell lines, 19 we found that RPE cells isolated from an epiretinal membrane of a PVR patient (RPEM) also expressed PDGFR␣ (Fig. 1A).…”

Expression of PDGFRα Is a Determinant of the PVR Potential of ARPE19 Cells

“…We considered PDGFR␣ a mediator of PVR because PDGFR␣ potently enhances the PVR potential of fibroblasts. 14,28 Consistent with previous studies using RPE cell lines, 19 we found that RPE cells isolated from an epiretinal membrane of a PVR patient (RPEM) also expressed PDGFR␣ (Fig. 1A).…”

Growth factors in proliferative vitreoretinopathy

“…Their essential finding is that levels of both PDGF and basic fibroblast growth factor (bFGF) are significantly raised in the vitreous of eyes with retinal detachment and PVR but not in eyes with retinal detachment without PVR. Both growth factors are known to be involved in the upregulation of wound healing1 2 and the findings support previous observations that PDGF protein and its receptor are present on PVR epiretinal membranes16 and in vitro work suggesting a role for PDGF and bFGF in PVR 35 22 An association between raised PDGF levels and vitreous haemorrhage was also documented.…”

“…Both growth factors are known to be involved in the upregulation of wound healing1 2 and the findings support previous observations that PDGF protein and its receptor are present on PVR epiretinal membranes16 and in vitro work suggesting a role for PDGF and bFGF in PVR 35 22 An association between raised PDGF levels and vitreous haemorrhage was also documented. Vitreous haemorrhage is considered a risk factor for PVR25 although in this context it may in fact simply serve as a marker for blood-retinal barrier breakdown.…”

Prevalence and risk factors for epiretinal membranes in a Japanese population: the Hisayama study

“…The mechanism of the formation of idiopathic ERMs is not well known; however, glial cells, fibrocytes, retinal pigment epithelial (RPE) cells, and myofibrocytes are frequently implicated in idiopathic ERMs [2,6,10,23]. The migration of glial cells or RPE cells may be mediated by both biochemical and physiological factors, such as chemoattractants in serum and substances released from vascular endothelial cells or RPE cells themselves [3,4,5,19]. Smiddy et al speculated that those mediators and other biochemical interactions mediate cell migration and proliferation and consequently form ERMs [23].…”

Expression of PDGFRα Is a Determinant of the PVR Potential of ARPE19 Cells

“…We considered PDGFR␣ a mediator of PVR because PDGFR␣ potently enhances the PVR potential of fibroblasts. 14,28 Consistent with previous studies using RPE cell lines, 19 we found that RPE cells isolated from an epiretinal membrane of a PVR patient (RPEM) also expressed PDGFR␣ (Fig. 1A).…”

Growth factors in proliferative vitreoretinopathy

“…Their essential finding is that levels of both PDGF and basic fibroblast growth factor (bFGF) are significantly raised in the vitreous of eyes with retinal detachment and PVR but not in eyes with retinal detachment without PVR. Both growth factors are known to be involved in the upregulation of wound healing1 2 and the findings support previous observations that PDGF protein and its receptor are present on PVR epiretinal membranes16 and in vitro work suggesting a role for PDGF and bFGF in PVR 35 22 An association between raised PDGF levels and vitreous haemorrhage was also documented.…”

“…Both growth factors are known to be involved in the upregulation of wound healing1 2 and the findings support previous observations that PDGF protein and its receptor are present on PVR epiretinal membranes16 and in vitro work suggesting a role for PDGF and bFGF in PVR 35 22 An association between raised PDGF levels and vitreous haemorrhage was also documented. Vitreous haemorrhage is considered a risk factor for PVR25 although in this context it may in fact simply serve as a marker for blood-retinal barrier breakdown.…”

Prevalence and risk factors for epiretinal membranes in a Japanese population: the Hisayama study

“…The mechanism of the formation of idiopathic ERMs is not well known; however, glial cells, fibrocytes, retinal pigment epithelial (RPE) cells, and myofibrocytes are frequently implicated in idiopathic ERMs [2,6,10,23]. The migration of glial cells or RPE cells may be mediated by both biochemical and physiological factors, such as chemoattractants in serum and substances released from vascular endothelial cells or RPE cells themselves [3,4,5,19]. Smiddy et al speculated that those mediators and other biochemical interactions mediate cell migration and proliferation and consequently form ERMs [23].…”

Expression of PDGFRα Is a Determinant of the PVR Potential of ARPE19 Cells

“…We considered PDGFR␣ a mediator of PVR because PDGFR␣ potently enhances the PVR potential of fibroblasts. 14,28 Consistent with previous studies using RPE cell lines, 19 we found that RPE cells isolated from an epiretinal membrane of a PVR patient (RPEM) also expressed PDGFR␣ (Fig. 1A).…”

Growth factors in proliferative vitreoretinopathy

“…Their essential finding is that levels of both PDGF and basic fibroblast growth factor (bFGF) are significantly raised in the vitreous of eyes with retinal detachment and PVR but not in eyes with retinal detachment without PVR. Both growth factors are known to be involved in the upregulation of wound healing1 2 and the findings support previous observations that PDGF protein and its receptor are present on PVR epiretinal membranes16 and in vitro work suggesting a role for PDGF and bFGF in PVR 35 22 An association between raised PDGF levels and vitreous haemorrhage was also documented.…”

“…Both growth factors are known to be involved in the upregulation of wound healing1 2 and the findings support previous observations that PDGF protein and its receptor are present on PVR epiretinal membranes16 and in vitro work suggesting a role for PDGF and bFGF in PVR 35 22 An association between raised PDGF levels and vitreous haemorrhage was also documented. Vitreous haemorrhage is considered a risk factor for PVR25 although in this context it may in fact simply serve as a marker for blood-retinal barrier breakdown.…”

Prevalence and risk factors for epiretinal membranes in a Japanese population: the Hisayama study

“…The mechanism of the formation of idiopathic ERMs is not well known; however, glial cells, fibrocytes, retinal pigment epithelial (RPE) cells, and myofibrocytes are frequently implicated in idiopathic ERMs [2,6,10,23]. The migration of glial cells or RPE cells may be mediated by both biochemical and physiological factors, such as chemoattractants in serum and substances released from vascular endothelial cells or RPE cells themselves [3,4,5,19]. Smiddy et al speculated that those mediators and other biochemical interactions mediate cell migration and proliferation and consequently form ERMs [23].…”