Platelet Aggregation in Children With Helicobacter pylori Infection

Gürsel, Orhan; Atay, Avni; Kürekçi, Ahmet Emin; Avcu, Ferit; Nevruz, Oral; Şenses, Zeynep; Öztürk, Emel; Haşimi, Adnan; Ozcan, Okan

doi:10.1177/1076029609339747

Cited by 8 publications

(13 citation statements)

References 34 publications

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“…A study conducted by Gursel et al. showed that H. pylori infection may cause dysfunction of platelets in children and can be reversed by H. pylori eradication [16]. Those studies clearly demonstrate the existence of a close interaction between H. pylori and platelets, which surely merits further investigation.…”

Section: Hematologic Diseasesmentioning

confidence: 95%

Extragastric Manifestations of Helicobacter pylori Infection

et al. 2011

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In the previous year, some extragastric diseases, possibly linked to Helicobacter pylori infection, have been largely investigated. There are, in fact, several studies concerning cardiovascular diseases, lung diseases, hematologic diseases, eye and skin diseases, hepatobiliary diseases, diabetes mellitus, and neurological disorders. Among them, the relationship between bacterial CagA positivity and coronary heart disease is reportedly emphasized. Concerning normal tension glaucoma, new interesting data are playing in favor of the association with H. pylori infection. For other diseases, there are many interesting results, although more studies are needed to clarify the reality of the proposed association.

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Section: Hematologic Diseasesmentioning

confidence: 95%

Extragastric Manifestations of Helicobacter pylori Infection

et al. 2011

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“…A multi-center randomized controlled trial of H. pylori eradication in children with chronic ITP failed to show an effect of H. pylori eradication on platelet recovery [40]. Ferrara et al reported a positive effect of H. pylori eradication on the outcome of children with chronic ITP with a positive stool antigen test, although their study was not a randomized controlled trial [41].…”

Section: Idiopathic Thrombocytopenic Purpura (Itp) and Platelet Dysfumentioning

confidence: 99%

“…A multi‐center randomized controlled trial of H. pylori eradication in children with chronic ITP failed to show an effect of H. pylori eradication on platelet recovery [40]. Ferrara et al.…”

Section: Extra‐intestinal Manifestationsmentioning

confidence: 99%

Helicobacter pylori Infection and Childhood

2010

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Pediatric‐based Helicobacter pylori research continues to contribute significantly to our understanding of both clinical and pathophysiological aspects of this infection. Here, we review the published pediatric H. pylori literature from April 2009–March 2010. Analysis of pediatric H. pylori strains continues to suggest that cagA+ and cagPAI competent strains are less prevalent than in adult isolates. Studies from the Middle East report a high H. pylori prevalence and intrafamilial transmission. Data continue to show a lack of association between H. pylori and recurrent abdominal pain of childhood, gastroesophageal reflux disease, and growth retardation. Recent probiotic trials have not shown a benefit on H. pylori eradication in children, while sequential therapy remains an attractive therapeutic eradication strategy in children, which requires validation in different geographic regions.

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“…All these studies have raised a question whether H. pylori infection affects platelet functions. On the other hand, Gursel et al [3] demonstrated that H. pylori infection in children may significantly decrease platelet response to ADP (ADP-like defect), which can be reversed by eradication therapy.…”

Section: Discussionmentioning

confidence: 99%