Platelet Activation in Obese Women

Abstract

Android obesity is associated with enhanced lipid peroxidation and persistent platelet activation. These abnormalities are driven by inflammatory triggers related to the degree of abdominal adiposity and are, at least in part, reversible with a successful weight-loss program.

Thromboxane-Dependent Platelet Activation in Obese Subjects with Prediabetes or Early Type 2 Diabetes: Effects of Liraglutide- or Lifestyle Changes-Induced Weight Loss

“…Of interest is the counterintuitive finding that the extent of SAT, unlike VAT, is related and is possibly a determinant of platelet activation. This finding is, in appearance, in contrast to our previous results of a higher degree of TX-dependent platelet activation in android obesity, defined as waist hip ratio (WHR) higher than 0.86, roughly reflecting visceral or central obesity [5]. However, the accuracy of MRI in the detection of abdominal subcutaneous fat as opposed to visceral fat is much higher than the antropometric estimate [41], and no study until now had evaluated the relationship between adipose tissue distribution and platelet activation.…”

F2-Isoprostanes Reflect Oxidative Stress Correlated With Lean Mass and Bone Density but Not Insulin Resistance

“…In terms of body composition, no linear association was found between F2-isoPs and either BMI or measures of body fat (total fat mass, body fat percentage, trunk fat, waist and hip circumference). This finding seems contrary to studies demonstrating that F2-isoP levels are correlated with BMI [ 15 , 34 ] and with studies that show oxidative stress tend to decrease with weight loss [ 35 ]. One possibility for this incongruence is that we provided all participants with a standardized, isocaloric diet for 3 days before study measurements.…”

Effect of Modest Caloric Restriction on Oxidative Stress in Women, a Randomized Trial

“…Our results showing decreased F 2 -isoprostane with weight loss are consistent with a previous Davi et al [40] study involving 11 obese women who participated in a diet-induced weight loss program for a 12-week period and lost at least 5 kg of initial body weight. In eight of these women, there was a significant reduction in urinary excretion of F 2 -isoprostane.…”