Platelet activation and inflammatory response in patients with non-dipper hypertension

Kaya, Mehmet; Yarlıoğlueş, Mikail; Günebakmaz, Özgür; Güntürk, Ertuğrul Emre; İnanç, Tuğrul; Doğan, Ali; Kalay, Nihat; Topsakal, Ramazan

doi:10.1016/j.atherosclerosis.2009.09.010

Cited by 112 publications

(84 citation statements)

References 34 publications

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“…6 Besides blood pressure level, blood pressure characteristics, including blood pressure pattern, morning surge and the diurnal/nocturnal blood pressure ratio are all independent risk factors for cardiovascular disease (CVD). [7][8][9] Normalization of the circadian rhythm of blood pressure is considered to be an important clinical goal of pharmacotherapy. Due to the time-dependent kinetics of medications, as well as normal circadian rhythms during drug-free times, and the rate-limiting steps of key metabolic pathways, it is not surprising that anti-hypertensive medications would display circadian-dependent effects.…”

Section: Introductionmentioning

confidence: 99%

Fixed-combination of amlodipine and diuretic chronotherapy in the treatment of essential hypertension: improved blood pressure control with bedtime dosing—a multicenter, open-label randomized study

et al. 2011

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Previous studies have demonstrated that individual anti-hypertension medications have different effects when administered in the morning vs. the evening. However, the impact of administration timing on fixed combinations of anti-hypertensive medications on blood pressure control is still unknown. In the present study, we examined the administration time-dependent effects of a fixed combination of amlodipine and diuretics (amlodipine complex) on blood pressure in hypertensive subjects. Eighty patients from Chongqing City were enrolled in this study. Subjects were randomly assigned to receive a single pill (amlodipine complex, each tablet containing amlodipine 5 mg and hydrochlorothiazide 25 mg), either in the morning (0800 hours, n¼40) or at bedtime (2200 hours, n¼40). Blood pressure was measured by ambulatory monitoring every 20 min during the day and every 30 min at night for 24 consecutive hours before and after the 12 weeks of treatment. Following treatment, the 24-h mean systolic and diastolic blood pressures were reduced significantly in both the morning and bedtime groups. However, the morning blood pressure surge was reduced to a greater degree in the bedtime group. In addition, the nocturnal blood pressure and the 24 h mean blood pressure were lower in the bedtime group. More patients converted from having a non-dipper to dipper blood pressure in the bedtime group. These findings confirm that amlodipine complexes have different efficiencies depending on treatment time. Administration of amlodipine complexes at bedtime could optimize the anti-hypertensive effect by augmenting blood pressure-lowering effects, increasing the diurnal/nocturnal ratio of blood pressure, normalizing the blood pressure pattern and minimizing the morning blood pressure surge.

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Section: Introductionmentioning

confidence: 99%

Fixed-combination of amlodipine and diuretic chronotherapy in the treatment of essential hypertension: improved blood pressure control with bedtime dosing—a multicenter, open-label randomized study

et al. 2011

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“…Based on ambulatory BP measurements, hypertensive subjects are divided into two groups: dippers and non-dippers. Despite some conflicting reports, evidence indicates that non-dipper hypertension, which was defined as a reduction in nighttime BP of less than 10% compared to the daytime BP, carries a potential high risk for atherosclerosis, left ventricular hypertrophy, stroke, adverse coronary events, and renal failure [4,5,6,7,8]. Although the exact underlying mechanism leading to increased cardiovascular events in non-dippers is still unclear, some logical relations between non-dipping hypertension and target organ damage have been reported so far.…”

Section: Introductionmentioning

confidence: 99%

Red Blood Cell Distribution Width in ‘Non-Dippers’ versus ‘Dippers’

et al. 2012

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Objectives: Because both high red cell distribution width (RDW) and non-dipping hypertension are closely related to adverse cardiovascular outcomes and higher inflammatory status, we aimed to investigate whether there is any relationship between RDW and dipping/non-dipping hypertension status. Methods: The present study involved 123 hypertensive patients and 65 age- and gender-matched healthy, normotensive subjects. Hypertensive patients were divided into two groups: 56 dipper patients (20 males, mean age 51.9 ± 15.3 years) and 67 non-dipper patients (27 males, mean age 55.6 ± 15.0 years). If the systolic daytime blood pressure (BP) of the patients decreased by at least 10% during the nighttime, these subjects were ‘dippers’, and all other subjects were ‘non-dippers’. Results: Both dipper patients and non-dipper patients had higher levels of RDW compared to normotensives (13.5 ± 0.89 and 14.1 ± 1.33 vs. 13.0 ± 1.42%, p = 0.027 and p <0.001, respectively). Also RDW values in non-dippers were statistically higher compared to those in dippers (p = 0.008). Although there were negative correlations between RDW values and nocturnal systolic BP fall (p = 0.027, r = –0.199) and diastolic BP fall (p = 0.383, r = –0.079) in all hypertensive patients, these correlations did not reach a statistically significant level. Conclusion: Our study demonstrates that non-dippers have high RDW levels compared to both dippers and controls.

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“…It can cause cardiovascular problems, neurologic problems, psychiatric problems, endocrine problems, gastrointestinal problems and hematologic problems. Even though there is limited data, these patients have been reported to have a decreased survival rate [11].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Changes In Mean Platelets Volume In Children With Adenotonsillar Hypertrophy

Arıcıgil¹

2017

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Objective: Adenotonsillar hypertophy is the most common cause of upper airway obstruction seen in children. Adenotonsillar hypertrophy is known to cause cardiac and pulmonary disfunctions. The most important reason for this is hypoventilation. Hypoventilation could lead to hypercoagulopathy. Mean platelet volume is the most important parameter that shows thrombocyte size. Larger thrombocytes contain more enzymatic granules and this is an indication that more prothrombotic activities will occur. In this study we researched on the changes in Mean platelet levels after adenotonsillectomy in patients with adenotonsillar hypertrophy. Methods:The mean platelet volume of 45 patients of ages 3-9 years were retrospectively evaluated before and after operation due to adenotonsillar hypertrophy between the years 2011-2015.Results: There was no significant difference in Hemoglobin, White blood cells, and Mean Platelet Volume between the preoperative and postoperative values however there was a significant decrease in platelet count. Conclusion:There was no signifant change in Mean Platelet Volume but a decrease in platelet volume was seen in almost 50% of the patients.

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Platelet activation and inflammatory response in patients with non-dipper hypertension

Cited by 112 publications

References 34 publications

Fixed-combination of amlodipine and diuretic chronotherapy in the treatment of essential hypertension: improved blood pressure control with bedtime dosing—a multicenter, open-label randomized study

Fixed-combination of amlodipine and diuretic chronotherapy in the treatment of essential hypertension: improved blood pressure control with bedtime dosing—a multicenter, open-label randomized study

Red Blood Cell Distribution Width in ‘Non-Dippers’ versus ‘Dippers’

Evaluation of Changes In Mean Platelets Volume In Children With Adenotonsillar Hypertrophy

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