Plastid-nucleus communication involves calcium-modulated MAPK signalling

Guo, Hailong; Feng, Peiqiang; Chi, Wei; Sun, Xuwu; Xu, Xiumei; Li, Yuan; Ren, Dongtao; Lu, Congming; Rochaix, Jean David; Leister, Dario; Zhang, Lixin

doi:10.1038/ncomms12173

Cited by 73 publications

(66 citation statements)

References 71 publications

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“…In fact, evidence for this scenario was provided recently by the finding that ABI4, a central TF involved in different chloroplast retrograde signaling pathways, was phosphorylated by the MAP kinase MPK6 in a Ca 2+ -dependent manner (Guo et al, 2016). Strikingly, MPK6 also was recently found to be regulated by SnRK1 under hypoxia conditions (Cho et al, 2016).…”

Section: Anterograde Signals To Organelles Via Phosphorylation Of Tramentioning

confidence: 88%

The SnRK1 Kinase as Central Mediator of Energy Signaling between Different Organelles

et al. 2018

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The evolutionarily conserved SNF1-related protein kinase 1 (SnRK1) kinase complex is a key regulator in adjusting cellular metabolism during starvation, stress conditions, and growth-promoting conditions. Over the last two decades, extensive genetic evidence for a widespread SnRK1 signaling network has accumulated. It is now well established that SnRK1 is a central integrator of energy signaling. However, little is known about the connections between the cytoplasmic and nuclear-localized SnRK1 and plastids and mitochondria as the main energy-producing compartments in the cell. Here, we review recent findings indicating how SnRK1 affects metabolic adaptation, including plastidial and mitochondrial functions. Special emphasis is put on identified direct targets of SnRK1, which would eventually enable cross talk with organelles. In this context, a number of transcription factors (TFs) are emerging as mediators of SnRK1 signaling, potentially linking SnRK1 activity to organellar functions. Furthermore, many SnRK1 targets act in various hormonal signaling pathways, which are at least partly localized in plastids. With this review, we summarize the current knowledge on SnRK1 organelle interaction and provide ideas on the potential molecular mechanisms governing these interactions. METABOLIC REPROGRAMMING BY SNRK1 KINASE ACTIVITY UNDER DIFFERENT GROWTH AND STRESS CONDITIONSAlready under optimal growth conditions, plants need to continuously adjust their metabolic balance between autotrophic growth based on photosynthesis during the day and respiration during the night. At daytime, sugars and other metabolites are produced by photosynthesis in chloroplasts and further distributed to be used in other metabolic pathways at different cellular compartments or transported to nonphotosynthetic sink tissues. During the night, starch and sugars supply carbon equivalents for respiration, providing the necessary energy for further growth and metabolic activities. Additionally, metabolic reprogramming is required for plants to adjust their metabolism to diverse biotic and abiotic environmental stimuli. This often leads to a stop of plant growth involving a reduction in ribosomal protein synthesis, and in parallel, accumulation of protective metabolites or defense compounds. This switching of cellular energy metabolism is mediated by the activity of the evolutionarily conserved AMPK/ SNF1/SnRK1 kinase complex (Box 1; Crozet et al.,

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Section: Anterograde Signals To Organelles Via Phosphorylation Of Tramentioning

confidence: 88%

The SnRK1 Kinase as Central Mediator of Energy Signaling between Different Organelles

et al. 2018

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“…Further work is needed to indentify the specific signals that drive ANN5-dependent reprogramming of plastid function. Recent studies revealed that retrograde regulation of the nuclear gene expression involved calcium signaling [37]. Calcium ions were released from the plastids to the cytosol in response to specific stimuli [38].…”

Section: Discussionmentioning

confidence: 99%

Nucleus- and plastid-targeted annexin 5 promotes reproductive development in Arabidopsis and is essential for pollen and embryo formation

Lichocka

Rymaszewski

Morgiewicz

et al. 2018

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“…Moreover, emerging evidence indicates that chloroplasts contribute to cellular Ca 2+ -homeostasis and signaling and identified the chloroplast Ca 2+ sensor protein (CAS) as a central component in these processes (Nomura et al, 2007(Nomura et al, , 2012Weinl et al, 2008;Petroutsos et al, 2011;Hochmal et al, 2015). In Arabidopsis, CAS crucially functions in the generation of cytosolic and stromal Ca 2+ transients as well as in the modulation of MAPK signaling (Guo et al, 2016). Moreover, it is involved in photo-acclimation in Chlamydomonas reinhardtii by contributing to the control of expression of LHCSR3 and to the expression of proteins related to the carbon-concentrating mechanism (Petroutsos et al, 2011;Wang et al, 2016b).…”

Section: Ca 2+ Signaling In Mitochondria and Chloroplastsmentioning

confidence: 99%

Advances and current challenges in calcium signaling

et al. 2018

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Content Summary414I.Introduction415II.Ca2+ importer and exporter in plants415III.The Ca2+ decoding toolkit in plants415IV.Mechanisms of Ca2+ signal decoding417V.Immediate Ca2+ signaling in the regulation of ion transport418VI.Ca2+ signal integration into long‐term ABA responses419VIIIntegration of Ca2+ and hormone signaling through dynamic complex modulation of the CCaMK/CYCLOPS complex420VIIICa2+ signaling in mitochondria and chloroplasts422IXA view beyond recent advances in Ca2+ imaging423XModeling approaches in Ca2+ signaling424XIConclusions: Ca2+ signaling a still young blooming field of plant research424Acknowledgements425ORCID425References425 Summary Temporally and spatially defined changes in Ca2+ concentration in distinct compartments of cells represent a universal information code in plants. Recently, it has become evident that Ca2+ signals not only govern intracellular regulation but also appear to contribute to long distance or even organismic signal propagation and physiological response regulation. Ca2+ signals are shaped by an intimate interplay of channels and transporters, and during past years important contributing individual components have been identified and characterized. Ca2+ signals are translated by an elaborate toolkit of Ca2+‐binding proteins, many of which function as Ca2+ sensors, into defined downstream responses. Intriguing progress has been achieved in identifying specific modules that interconnect Ca2+ decoding proteins and protein kinases with downstream target effectors, and in characterizing molecular details of these processes. In this review, we reflect on recent major advances in our understanding of Ca2+ signaling and cover emerging concepts and existing open questions that should be informative also for scientists that are currently entering this field of ever‐increasing breath and impact.

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Plastid-nucleus communication involves calcium-modulated MAPK signalling

Cited by 73 publications

References 71 publications

The SnRK1 Kinase as Central Mediator of Energy Signaling between Different Organelles

The SnRK1 Kinase as Central Mediator of Energy Signaling between Different Organelles

Nucleus- and plastid-targeted annexin 5 promotes reproductive development in Arabidopsis and is essential for pollen and embryo formation

Advances and current challenges in calcium signaling

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