Plasticity of GABA(a) system during ageing: focus on vestibular compensation and possible pharmacological intervention

Giardino, Luciana; Zanni, Massimo; Fernández, Mercedes; Battaglia, Agatino; Pignataro, O; Calzà, Laura

doi:10.1016/s0006-8993(01)03381-9

Cited by 37 publications

(22 citation statements)

References 62 publications

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“…According to recent data, it suggested that GABA and glycine can play an important in the developing and mature central vestibular system [67]. In turn, in neurons of the vestibular nuclei by the GABA receptor mediated vestibular compensation after unilateral labyrinthectomy [67][68][69][70]. In this paper, where besides H for the first time are studied of Am and NM on the model of AD and also it is possible the involvement of true GABAergic inhibition during tetanic depression, with the aim of its deepening in the structures studied, thus supposed need of protectors for therapeutic intervention in the process of de and regeneration.…”

Section: Resultsmentioning

confidence: 99%

Morphofunctional Correlation of Excitatory and Depressor Synaptic Processes in Hippocampus, Amygdala and Basal Meynert Nucleus Neurons in Dynamics of Development of Alzheimer's Disease Model Induced by Aβ25-35

Js¹,

Al²,

Kt³

et al. 2017

J Alzheimers Dis Parkinsonism

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Section: Resultsmentioning

confidence: 99%

Morphofunctional Correlation of Excitatory and Depressor Synaptic Processes in Hippocampus, Amygdala and Basal Meynert Nucleus Neurons in Dynamics of Development of Alzheimer's Disease Model Induced by Aβ25-35

Js¹,

Al²,

Kt³

et al. 2017

J Alzheimers Dis Parkinsonism

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“…Furthermore, contemporary studies at the cellular and neurotransmitter levels have shown that synaptic inhibition cannot be evaluated only as opposing synaptic excitation, but also serve highly specifi c functions in the nervous system in mammals [9]. Our own data indicate that depres- sor reactions are more intensely involved in both nonspecifi c (peripheral, central) and specifi c neurodegeneration in different parts of the brain [17,18,27].…”

Section: Discussionmentioning

confidence: 95%

“…It was further suggested that GABA and glycine may also play in important and perhaps changing role in the mature central vestibular system [25]. In its turn, events determined by GABA receptors in neurons in the vestibular nuclei have been shown to play a decisive role in the recovery of functions after unilateral labyrinthectomy [18,20,30]. Furthermore, contemporary studies at the cellular and neurotransmitter levels have shown that synaptic inhibition cannot be evaluated only as opposing synaptic excitation, but also serve highly specifi c functions in the nervous system in mammals [9].…”

Section: Discussionmentioning

confidence: 99%

“…with transfer to mechanical ventilation. After dorsal laminectomy of the lumbosacral segment of the spinal cord, glass microelectrodes with a tip diameter of 1 μm fi lled with 2 M NaCl solution, stereotaxically orientated using an atlas [18], were implanted in the anterior horn of the gray matter of the lumbar segments (L4-L5) in the area containing spinal cord motoneurons (Rexed laminae VIII-IX) for extracellular recording of baseline and evoked spike activity from individual motoneurons using high-frequency stimulation (HFrS) (0.05 msec, 0.8-1.6 mA, 50 and 100 Hz, for 1 sec) from bipolar silver electrodes ipsilateral to the extensor (common peroneal -P) and fl exor (gastrocnemius -G) nerves of the hindlimb. Excitatory and depressor post-stimulus effects were evaluated in terms of tetanic potentiation (TP) and depression (TD) of motoneuron response frequency followed by post-tetanic signs in the form of post-tetanic potentiation (PTP) and depression (PTD).…”

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confidence: 99%

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Electrophysiological Analysis of the Functional State of Spinal Cord Motoneurons in Rats with Parathyroprivous Tetany

Khudaverdyan¹,

Avetisyan²,

Chavushyan

et al. 2015

Neurosci Behav Physi

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Calcium ions are known to have a direct involvement in controlling and regulating a wide spectrum of neuron functions, including the growth of processes, synaptogenesis, synaptic transmission, plasticity, and survival, and dysregulation of these functions leads to the development of synaptic dysfunction, impaired plasticity, and the development of various neuropathological disorders [15,22]. The discovery of the ability of calcium to work as an external ligand allowed it to be regarded as a fi rst messenger [11]. Infl ux of Ca 2+ through voltage-and ligand-dependent channels in the plasma membrane makes it the main trigger for transmitter release from presynaptic terminals [10,32]. This transmitter release is under the control of N and P/Q Ca 2+ channels, such that decreases in Ca 2+ levels lead to impairment to transmitter release and, thus, normal neuron functioning [24]. Further studies showed that neuron activity is accompanied by increases in transiently calmodulin-bound cytosolic Ca 2+ concentrations as a second messenger, though in aging and disease the ability of neurons to control Ca 2+ levels is impaired [22]. Decreases in calcium ions in the surrounding medium are accompanied by impairments to the membrane permeability of the Na + / Ca 2+ exchange mechanism, with effl ux of Ca 2+ from and infl ux of Na + into the cytoplasm, leading ultimately to depolarization of cell membranes and increases in cell excitability [1]. Studies using the hippocampus as an example showed that low Ca 2+ levels combined with high K + act together to generate stable epileptiform activity [14]. These authors also demonstrated that in conditions of blockade of synaptic transmission, epileptiform activity can be induced by a non-synaptic mechanism [14]. It should be emphasized that all these calcium-dependent processes are under the specifi c control of the calcium-regulating system, where the key role is played by parathyroid hormone (PTH), produced by the parathyroid glands. PTH, as we have demonstrated [2,21], is a major modulator of the functional activity of neurons which operate as the target for hormone action. This action of PTH A comparative analysis of baseline activity, tetanic and post-tetanic increases and decreases in the frequencies of spinal cord motoneuron responses to high-frequency (50 and 100 Hz) stimulation (HFrS) of the fl exor (G) and extensor (P) nerves of the hindlimb was performed in normal rats and rats with parathyroprivous (hypocalcemic) tetany. Experiments were run using on-line selection and programmed analysis of spike activity. Signifi cant shifts in tetanic and post-tetanic motoneuron activity were recorded on days 3-7 and 21-22 of the development of acute and chronic tetanization respectively, without any signifi cant change in baseline activity. Along with sharp increases in post-stimulus excitatory changes in activity in response to HFrS during the development of acute tetany, there was relative weakening in animals with chronic tetany. At the same time, there was weakening or complete disapp...

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“…Late compensation is associated with no change in the muscimol or [ 3 H]flunitrazepam binding sites (Calza et al, 1989(Calza et al, , 1992Johnston et al, 2001;Giardino et al, 2002). Results from polymerase chain reaction studies suggest that there is a significant increase in the GABA A receptor ␣ 1 subunit mRNA expression in the ipsilateral VNC compared with the contralateral VNC, at 6 h, but not at 50 h post-UVD (Horii et al, 2003).…”

mentioning

confidence: 99%

Effects of Chronic Infusion of a GABA_A Receptor Agonist or Antagonist into the Vestibular Nuclear Complex on Vestibular Compensation in the Guinea Pig

Gliddon

Darlington²,

Smith³

2005

J Pharmacol Exp Ther

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The aim of this study was to determine the effects of chronic infusion of a GABA A receptor agonist/antagonist into the ipsilateral or contralateral vestibular nuclear complex (VNC) on vestibular compensation, the process of behavioral recovery that occurs after unilateral vestibular deafferentation (UVD). This was achieved by a mini-osmotic pump that infused, over 30 h, muscimol or gabazine into the ipsilateral or contralateral VNC. Spontaneous nystagmus (SN), yaw head tilt (YHT), and roll head tilt (RHT) were measured. Infusion of muscimol or gabazine into either the ipsilateral or the contralateral VNC had little effect on SN compensation. In contrast, infusion of muscimol (250, 500, and 750 ng) into the contralateral VNC and gabazine (31.25, 62.5, and 125 ng) into the ipsilateral VNC significantly affected YHT and RHT (p Ͻ 0.05), but not their rate of compensation (p Ͼ 0.05). Interestingly, the effects of muscimol and gabazine on YHT and RHT were consistent throughout the first 30 h post-UVD. Infusion of muscimol (62.5, 125, and 250 ng) into the ipsilateral VNC and gabazine (125, 375, and 750 ng) into the contralateral VNC had little effect on YHT and RHT or their rate of compensation. These results suggest that the ipsilateral gabazine and contralateral muscimol infusions are modifying the expression of the symptoms without altering the mechanism of compensation. Furthermore, the neurochemical mechanism responsible for vestibular compensation can cope with the both the GABA A receptor-mediated and the UVD-induced decrease in resting activity.

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Plasticity of GABA(a) system during ageing: focus on vestibular compensation and possible pharmacological intervention

Cited by 37 publications

References 62 publications

Morphofunctional Correlation of Excitatory and Depressor Synaptic Processes in Hippocampus, Amygdala and Basal Meynert Nucleus Neurons in Dynamics of Development of Alzheimer's Disease Model Induced by Aβ25-35

Morphofunctional Correlation of Excitatory and Depressor Synaptic Processes in Hippocampus, Amygdala and Basal Meynert Nucleus Neurons in Dynamics of Development of Alzheimer's Disease Model Induced by Aβ25-35

Electrophysiological Analysis of the Functional State of Spinal Cord Motoneurons in Rats with Parathyroprivous Tetany

Effects of Chronic Infusion of a GABA_A Receptor Agonist or Antagonist into the Vestibular Nuclear Complex on Vestibular Compensation in the Guinea Pig

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Plasticity of GABA(a) system during ageing: focus on vestibular compensation and possible pharmacological intervention

Cited by 37 publications

References 62 publications

Morphofunctional Correlation of Excitatory and Depressor Synaptic Processes in Hippocampus, Amygdala and Basal Meynert Nucleus Neurons in Dynamics of Development of Alzheimer's Disease Model Induced by Aβ25-35

Morphofunctional Correlation of Excitatory and Depressor Synaptic Processes in Hippocampus, Amygdala and Basal Meynert Nucleus Neurons in Dynamics of Development of Alzheimer's Disease Model Induced by Aβ25-35

Electrophysiological Analysis of the Functional State of Spinal Cord Motoneurons in Rats with Parathyroprivous Tetany

Effects of Chronic Infusion of a GABAA Receptor Agonist or Antagonist into the Vestibular Nuclear Complex on Vestibular Compensation in the Guinea Pig

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Effects of Chronic Infusion of a GABA_A Receptor Agonist or Antagonist into the Vestibular Nuclear Complex on Vestibular Compensation in the Guinea Pig