Plastic changes to dendritic spines on layer V pyramidal neurons are involved in the rectifying role of the prefrontal cortex during the fast period of motor learning

González-Tapia, David; Martínez-Torres, Nestor I.; Hernández‐González, Marisela; Guevara, Miguel Ángel; González-Burgos, Ignacio

doi:10.1016/j.bbr.2015.11.013

Cited by 14 publications

(8 citation statements)

References 45 publications

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“…Thin spines (with narrow necks) show high mobility–they can be rapidly modified by neuronal activity changes (“write-enabled” spines) [20,21] and they are associated with learning new information (‘learning spines’) [2]. Mushroom spines (with large heads and relatively wide necks) are most stable spines (“write-protected” spines) [10,15,20–22] and they are considered to be involved in memory formation (‘memory spines’) [2].…”

Section: Introductionmentioning

confidence: 99%

Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex

et al. 2019

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Circadian rhythmicity affects neuronal activity induced changes in the density of synaptic contacts and dendritic spines, the most common location of synapses, in mouse somatosensory cortex. In the present study we analyzed morphology of single- and double-synapse spines under light/dark (12:12) and constant darkness conditions. Using serial electron micrographs we examined the shape of spines (stubby, thin, mushroom) and their content (smooth endoplasmic reticulum, spine apparatus), because these features are related to the maturation and stabilization of spines. We observed significant diurnal and circadian changes in the shape of spines that are differentially regulated: single-synapse spines remain under circadian clock regulation, while changes of double-synapse spines are driven by light. The thin and mushroom single-synapse spines, regardless of their content, are more stable comparing with the stubby single-synapse spines that show the greatest diversity. All types of double-synapse spines demonstrate a similar level of stability. In light/dark regime, formation of new mushroom single-synapse spines occurs, while under constant darkness new stubby single-synapse spines are formed. There are no shape preferences for new double-synapse spines. Diurnal and circadian alterations also concern spine content: both light exposure and the clock influence translocation of smooth endoplasmic reticulum from dendritic shaft to the spine. The increasing number of mushroom single-synapse spines and the presence of only those mushroom double-synapse spines that contain spine apparatus in the light phase indicates that the exposure to light, a stress factor for nocturnal animals, promotes enlargement and maturation of spines to increase synaptic strength and to enhance the effectiveness of neurotransmission.

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Section: Introductionmentioning

confidence: 99%

Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex

et al. 2019

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“…Satisfactorily, the HI animals trained in an AE protocol demonstrated short‐term memory recovery. The motor skill learning associated to acrobatic training leads to an increase in striatal pathways stimulation (Le Merrer et al., 2013; Lovinger, 2010; Yin et al., 2009) and on ability learning (Anaya et al., 2017; González‐Tapia et al., 2016; Kida et al., 2016; Salame et al., 2016; Tamakoshi et al., 2014). Another study that evaluated AE in HI‐model observed anxiety‐like behavior and hyperactivity recovery (Confortim et al., 2019), that are deficits related to striatum dysfunctions or corticostriatal inputs alterations (Corbit et al., 2019; Griva et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

“…One of these MST protocols is the acrobatic exercise (AE) which involves complex motor skill activities with the aim of stimulating motor control and also neuroplasticity abilities (Black et al., 1990; Confortim et al., 2019; Gutierrez et al., 2018; Jones et al., 1999; Tamakoshi et al., 2016). This type of training has improved the aversive memory performance related to hippocampus epigenetic mechanisms (de Meireles et al., 2019) and increased the synaptophysin levels and BDNF expression in different brain areas, indicating synaptogenesis (Garcia et al., 2012; González‐Tapia et al., 2016; Klintsova et al., 2004). Our recent study showed that AE alleviated the hyperactivity and anxiety state, which are very dependent tasks of the prefrontal cortex and striatum, in animals submitted to the HI (Confortim et al., 2019); however, the impact of AE on others variables such as cognitive function have not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Acrobatic exercise recovers object recognition memory impairment in hypoxic‐ischemic rats

Almeida

Confortim

Deniz

et al. 2020

Intl J of Devlp Neuroscience

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Neonatal hypoxia‐ischemia (HI) can lead to cognitive impairments and motor dysfunction. Acrobatic exercises (AE) were proposing as therapeutic option to manage HI motor deficits, however, the cognitive effects after this treatment are still poorly understood. Therefore, we evaluated the effects of AE protocol on memory impairments and brain plasticity markers after Rice–Vannucci HI rodent model. Wistar rats on the 7th postnatal day (PND) were submitted to HI model and after weaning (PND22) were trained for 5 weeks with AE protocol, then subsequently submitted to cognitive tests. Our results showed recovery in novel object recognition (NOR) memory, but not, spatial Morris Water Maze (WM) memory after AE treatment in HI rats. BDNF and synaptophysin neuroplasticity markers indicate plastic alterations in the hippocampus and striatum, with maintenance of synaptophysin despite the reduction of total volume tissue, besides, hippocampal HI‐induced ipsilateral BDNF increased, and striatum contralateral BDNF decreased were noted. Nevertheless, the exercise promoted functional recovery and seems to be a promising strategy for HI treatment, however, future studies identifying neuroplastic pathway for this improvement are needed.

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“…The current research on dendritic spines pattern is mainly performed by statically observing the cerebral cortex in animals (Kommaddi et al, 2018;Ratliff et al, 2019). It has been confirmed that the pattern of dendritic spines is influenced by neuron activity (Portera-Cailliau et al, 2003;González-Tapia et al, 2016) and some substances, such as drebrin (Hayashi et al, 1996), Rho GTPase Rac1 (Pyronneau et al, 2017) and F-actin (Kommaddi et al, 2018). The above researches usually only proposed one factor of dendritic spine patterns once while the pattern formation of dendritic spines is a dynamic process involving a variety of chemical reactions that are regulated by multiple factors.…”

Section: Introductionmentioning

confidence: 90%

Reaction–Diffusion Model-Based Research on Formation Mechanism of Neuron Dendritic Spine Patterns

et al. 2021

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The pattern abnormalities of dendritic spine, tiny protrusions on neuron dendrites, have been found related to multiple nervous system diseases, such as Parkinson's disease and schizophrenia. The determination of the factors affecting spine patterns is of vital importance to explore the pathogenesis of these diseases, and further, search the treatment method for them. Although the study of dendritic spines is a hot topic in neuroscience in recent years, there is still a lack of systematic study on the formation mechanism of its pattern. This paper provided a reinterpretation of reaction-diffusion model to simulate the formation process of dendritic spine, and further, study the factors affecting spine patterns. First, all four classic shapes of spines, mushroom-type, stubby-type, thin-type, and branched-type were reproduced using the model. We found that the consumption rate of substrates by the cytoskeleton is a key factor to regulate spine shape. Moreover, we found that the density of spines can be regulated by the amount of an exogenous activator and inhibitor, which is in accordance with the anatomical results found in hippocampal CA1 in SD rats with glioma. Further, we analyzed the inner mechanism of the above model parameters regulating the dendritic spine pattern through Turing instability analysis and drew a conclusion that an exogenous inhibitor and activator changes Turing wavelength through which to regulate spine densities. Finally, we discussed the deep regulation mechanisms of several reported regulators of dendritic spine shape and densities based on our simulation results. Our work might evoke attention to the mathematic model-based pathogenesis research for neuron diseases which are related to the dendritic spine pattern abnormalities and spark inspiration in the treatment research for these diseases.

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Plastic changes to dendritic spines on layer V pyramidal neurons are involved in the rectifying role of the prefrontal cortex during the fast period of motor learning

Cited by 14 publications

References 45 publications

Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex

Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex

Acrobatic exercise recovers object recognition memory impairment in hypoxic‐ischemic rats

Reaction–Diffusion Model-Based Research on Formation Mechanism of Neuron Dendritic Spine Patterns

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