Abstract:Introduction: Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. Methods: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a batch of 50 samples collected from 2003 to 2016 in Brazil. Results: We identified 1 K189T substitution located outside the propeller domain of the PfK13 protein in 36% of samples. Conclusions: Although the sample size is relatively small, these results suggest that P. falciparu… Show more
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