2006
DOI: 10.1152/ajpendo.00605.2004
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Abstract: Increased plasminogen activator inhibitor-1 (PAI-1) is linked to obesity and insulin resistance. However, the functional role of PAI-1 in adipocytes is unknown. This study was designed to investigate effects and underlying mechanisms of PAI-1 on glucose uptake in adipocytes and on adipocyte differentiation. Using primary cultured adipocytes from PAI-1+/+ and PAI-1−/− mice, we found that PAI-1 deficiency promoted adipocyte differentiation, enhanced basal and insulin-stimulated glucose uptake, and protected agai… Show more

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Cited by 112 publications
(85 citation statements)
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“…PAI-1 blocks the generation of plasmin, thereby silencing a major mechanism for ECM degradation and promoting ECM accumulation (22). PAI-1 expression is a characteristic of various immature fibrocytic cells, including bone marrow progenitors and pre-adipocytes (2,14). In such cells, PAI-1 maintains the fibroblastic phenotype by inhibiting cellular differentiation.…”
Section: Discussionmentioning
confidence: 99%
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“…PAI-1 blocks the generation of plasmin, thereby silencing a major mechanism for ECM degradation and promoting ECM accumulation (22). PAI-1 expression is a characteristic of various immature fibrocytic cells, including bone marrow progenitors and pre-adipocytes (2,14). In such cells, PAI-1 maintains the fibroblastic phenotype by inhibiting cellular differentiation.…”
Section: Discussionmentioning
confidence: 99%
“…In such cells, PAI-1 maintains the fibroblastic phenotype by inhibiting cellular differentiation. Treatment of 3T3-L1 pre-adipocytes with neutralizing antibodies to PAI-1 is sufficient to increase PPARγ activity and induce adipocytic differentiation (14). Adipocytic differentiation is similarly enhanced in mice by PAI-1 gene disruption (23).…”
Section: Discussionmentioning
confidence: 99%
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“…Liang et al showed that PAI-1 overexpression in 3T3-L1 cells inhibits adipocyte differentiation, while preadipocytes from PAI-1 -/-mice showed stronger differentiation. 35 However, a different study showed no effects of a PAI-1 neutralizing antibody or PAI-1 overexpression on adipogenesis of 3T3-F442A preadipocytes, and also comparable adipogenesis of PAI-1 -/-and wild type MEFs. 56 Investigations of mouse models appear controversial as well: Morange et al described faster weight gain of PAI1 -/-compared to wild type mice on a high-fat diet, 57 and a study of transgenic mice overexpressing PAI-1 under control of the adipocyte promoter aP2 showed reduced body protein levels by direct binding to the 3'UTRs of PAI-1 and ALK2.…”
Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning
confidence: 95%
“…PAI-1 is a protein secreted by adipose tissue 34 which has been implicated in various complications of the obese state, 31 though its role in adipogenesis appears controversial. 35,36 ALK2 is a bone morphogenetic protein (BMP) type I receptor known to mediate BMP7 signalling 37 and has been shown to regulate BMP9-induced osteogenic differentiation 38 as well as chondrogenesis. 39 Thus, a regulatory function of ALK2 might be hypothesized also for adipogenesis.…”
Section: O N O T D I S T R I B U T Ementioning
confidence: 99%