Plasma α1-antitrypsin

Abstract

Background:As an acute phase protein, α1-antitrypsin (AAT) has been extensively studied in acute coronary syndrome, but it is unclear whether a relationship exists between AAT and stable angina pectoris (SAP). The purpose of the present study was to investigate the association between AAT plasma levels and SAP.Methods:Overall, 103 SAP patients diagnosed by coronary angiography and clinical manifestations and 118 control subjects matched for age and gender were enrolled in this case-control study. Plasma levels of AAT, high-sensitivity C-reactive protein (hsCRP), lipid profiles and other clinical parameters were assayed for all participants. The severity of coronary lesions was evaluated based on the Gensini score (GS) assessed by coronary angiography.Results:Positively correlated with the GS (r = 0.564, P < 0.001), the plasma AAT level in the SAP group was significantly higher than that in the control group (142.08 ± 19.61 mg/dl vs. 125.50 ± 19.67 mg/dl, P < 0.001). The plasma AAT level was an independent predictor for both SAP (odds ratio [OR] = 1.037, 95% confidence interval [CI]: 1.020–1.054, P < 0.001) and a high GS (OR = 1.087, 95% CI: 1.051–1.124, P < 0.001) in a multivariate logistic regression model. In the receiver operating characteristic curve analysis, plasma AAT level was found to have a larger area under the curve (AUC) for predicting a high GS (AUC = 0.858, 95% CI: 0.788–0.929, P < 0.001) than that of hsCRP (AUC = 0.665, 95% CI: 0.557–0.773, P = 0.006; Z = 2.9363, P < 0.001), with an optimal cut-off value of 137.85 mg/dl (sensitivity: 94.3%, specificity: 68.2%).Conclusions:Plasma AAT levels correlate with both the presence and severity of coronary stenosis in patients with SAP, suggesting that it could be a potential predictive marker of severe stenosis in SAP patients.

Association between &alpha;1‑antitrypsin and acute coronary syndrome

“…Subsequently, Brunetti et al ( 41 ) detected elevated AAT levels in the plasma of patients with unstable angina pectoris. In 2015, Zhao et al ( 21 ) first indicated that the plasma concentrations of AAT in patients with stable angina pectoris were significantly higher than those in a healthy control population and positively correlated with the severity of coronary artery stenosis.…”

“…Plasma AAT levels have been demonstrated to correlate with both the presence and severity of coronary stenosis in patients with stable angina pectoris (SA) ( 21 ). However, at present, available studies on the association between plasma AAT concentrations and the severity of ACS are sparse and insufficient ( 21 ). Thus, it remains elusive whether plasma AAT is correlated with ACS.…”