Plasma volume changes associated with two hydroxyethyl starch colloids following acute hypovolaemia in volunteers

James, Michael F.; Latoo, M. Y.; Mythen, Michael G.; Mutch, M; Michaelis, Christian; Roche, Anthony; Burdett, Edward

doi:10.1111/j.1365-2044.2004.03811.x

Cited by 60 publications

(20 citation statements)

References 20 publications

(20 reference statements)

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“…In healthy volunteers, the volume expansion effect of Hextend (BioTime Inc., Berkeley, CA) is less well sustained than that of HES 130/0.4 18. Other studies also report similar results regarding favorable volume expansion and lesser compromised coagulation in patients treated with HES 130/0.4 than with other HES 10-12, 14-17, 19,20.…”

Section: Discussionmentioning

confidence: 89%

Effect of Rapid Plasma Volume Expansion during Anesthesia Induction on Haemodynamics and Oxygen Balance in Patients Undergoing Gastrointestinal Surgery

Lin

Li²,

Zhang³

et al. 2013

Int. J. Med. Sci.

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Aims: To investigate the reasonable dose of Voluven for rapid plasma volume expansion during the anaesthesia induction patients receiving gastrointestinal surgery. Methods: Sixty patients were randomly divided into three groups (n=20): Group A (5 ml/kg), Group B (7 ml/kg) and Group C (9 ml/kg). HES 130/0.4 was intravenously transfused at a rate of 0.3 ml/kg/min) at 30 min before anaesthesia induction. Besides standard haemodynamic monitoring, cardiac index (CI), systemic vascular resistance index (SVRI) and stroke volume variation (SVV) was continuously detected with the FloTrac/Vigileo system. Haemodynamic variables were recorded immediately before fluid transfusion (T0), immediately before induction (T1), immediately before intubation (T2), immediately after intubation (T3) and 5 min, 10 min, 20 min and 60 min after intubation (T4-T7). Arterial and venous blood was collected for blood gas analysis, Hb and Hct before volume expansion (t0), immediately after volume expansion (t1) and at 1 h after volume expansion (t2). Oxygen delivery (DO2), oxygen extraction ratio (ERO2) and volume expansion rate were calculated. Results: 1) MAP and CI decreased in Group A in T2~T7 and remained changed in Group B and C. 2) CVP increased in three groups after fluid infusion without significant difference. 3) The decrease in SVRI was more obvious in Group B and C than that in Group A after induction and more obvious in Group C than in Group B in T2-T4 and T6~T7. 4) SVV was lower in Group B and C than that in Group A after intubation, and lower in Group C than that in Group B in T3-T6. 5) Hb and Hct decreased after fluid infusion, and the decrease in Hb and Hct was in the order of C>B>A. 6) Volume expansion rate was in the order of C>B>A. 7) ScvO2, PaO2 and DO2 increased in three groups after fluid infusion and the increase in DO2 was in the order of C>B>A. Conclusions: Rapid plasma volume expansion with Voluven at 7-9 ml/kg can prevent haemodynamic fluctuation during anaesthesia induction, maintain the balance between oxygen supply and oxygen consumption during gastrointestinal surgery, and Voluven at 9 ml/kg can improve the oxygen delivery.

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Section: Discussionmentioning

confidence: 89%

Effect of Rapid Plasma Volume Expansion during Anesthesia Induction on Haemodynamics and Oxygen Balance in Patients Undergoing Gastrointestinal Surgery

Lin

Li²,

Zhang³

et al. 2013

Int. J. Med. Sci.

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“…Hydroxyethyl starch 130 and 450, vegetable-origin polysaccharides used mainly for plasma expansion [12], have been assessed ex vivo in pig and human corneas [13,14]. Hydroxyethyl starch 130 has been assessed as a supplement throughout OC in human corneas.…”

Section: Introductionmentioning

confidence: 99%

Poloxamines for Deswelling of Organ-Cultured Corneas

et al. 2012

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Background: Poloxamines are amphiphilic tetrofunctional block copolymers composed of four polyoxyethylene-polyoxypropylene arms joined to a central ethylene diamine bridge. Their safe profile allows diverse pharmaceutical and biomedical applications. Aim: To assess their use for corneal deswelling using a porcine model of organ culture (OC). Methods: Five poloxamines (T90R4, T904, T908, T1107 and T1307) were dissolved in a standard commercial OC medium (control) to reach 350 mosm kg^–1. In vitro cytotoxicity was tested using MTT assay on human corneal epithelial and endothelial cell (EC) lines and on primary human corneal fibroblasts. Paired porcine corneas stored in OC for 3 days were assigned for 48 h to a poloxamine medium or to a standard deswelling medium containing 5% dextran T500. Corneal EC density, morphometry, mortality, stromal thickness and transparency were evaluated before and after deswelling. Post-deswelling, EC viability/mortality was determined using a fluorescent live/dead assay. Results: Besides similar corneal thickness reduction and transparency improvement, T908, T1107 and T1307 decreased EC loss (5.4 ± 1.7% vs. 9.9 ± 2.6% in controls (p < 0.001)) and mortality, improved EC morphometry and reduced endothelial lesions compared to dextran. Conclusion: On this porcine model, poloxamines T908, T1107 and T1307 appear as good candidates to replace dextran for the deswelling. Experiments on human corneas are now necessary to confirm their efficiency and safety profile in OC.

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“…Most studies report similar hemodynamic effects between HES with higher MMW and MSR and HEs with lower MMW and MSR (Agrò and Vennari 2013b;Gandhi et al 2007;Ickx et al 2003). However, according to a report on a small sample population (20 patients) plasma volume expansion induced by an HES with low MMW and MSR (HES 130/0.4) is longer lasting than that achieved with the infusion of an HES with high MMW and MSR (HES 670/0.75) (Agrò and Vennari 2013b;James et al 2004).…”

Section: Comparison Between Hes and Other Colloidsmentioning

confidence: 92%