Plasma visfatin and retinol binding protein-4 levels in patients with type 2 diabetes mellitus and their relationship to adiposity and fatty liver

Shaker, Olfat G.; El-Shehaby, Amal; Zakaria, Abir; Mostafa, Naglaa; Talaat, Soha; Katsiki, Niki; Mikhailidis, Dimitri P.

doi:10.1016/j.clinbiochem.2011.08.1148

Cited by 41 publications

(42 citation statements)

References 49 publications

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“…Consistent with our findings, Sandeep et al showed that the visfatin secretion from adipocytes depends on the duration and extent of hyperglycemia (40). Accordingly, Shaker et al reported that high visfatin levels were positively related to glycemic control (41). Therefore, higher glucose and HbA1C levels may contribute to, at least partly, the increased visfatin levels found in T2DM patients.…”

Section: Discussionsupporting

confidence: 79%

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Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

Uslu

Kebapçı

Kara

et al. 2012

Experimental and Therapeutic Medicine

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Abstract. The aim of this study was to explore the relationship between serum profiles of adiponectin, leptin, resistin and visfatin and traditional and non-traditional cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM). A total of 85 patients with T2DM and 30 non-diabetic controls were enrolled in the study. Levels of adipocytokines (adiponectin, leptin, resistin and visfatin), lipids (total cholesterol, triglycerides), lipoproteins [HDL-cholesterol, LDL-cholesterol, lipoprotein (a)], apolipoproteins (Apo-A1 and Apo-B), non-traditional cardiovascular risk markers [asymmetric dimethylarginine (ADMA), homocysteine] and the inflammatory marker hs-CRP were measured, and anthropometric variables were determined. Serum adiponectin levels were decreased and leptin, resistin and visfatin levels were increased in T2DM patients compared to controls. They were associated with obesity (BMI), insulin resistance (HOMA-IR) and various markers of glucose/lipid profile, inflammation and endothelial dysfunction markers. These results suggest that decreased serum adiponectin and increased leptin, resistin and visfatin levels in T2DM may be novel biochemical risk factors for cardiovascular complications.

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Section: Discussionsupporting

confidence: 79%

“…In this study, we found increased visfatin levels in T2DM patients, as reported in previous studies (39,40). In addition, visfatin levels were positively correlated with HOMA-IR, L/A ratio and insulin levels in T2DM patients (41). El-Masallamy et al provided several explanations for the increased visfatin levels noted in patients with T2DM.…”

Section: Discussionsupporting

confidence: 73%

Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

Uslu

Kebapçı

Kara

et al. 2012

Experimental and Therapeutic Medicine

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“…Visfatin is recently discovered adipokine which is excreted by the visceral adipocytes (5,6) . It is known that blood vessels express receptors for most of the adipocyte-derived factors.…”

Section: Discussionmentioning

confidence: 99%

“…It is secreted from the visceral fat. It exhibits insulin-like functions (5,6) . Visfatin was also recognized as the formerly described nicotinamide phosphoribosyl transferase (NAMPT), which is the rate-limiting enzyme in the nicotinamide dinucleotide (NAD) biosynthetic pathway starting from nicotinamide and catalyzes the synthesis of nicotinamide mononucleotide (NMN) from nicotinamide and 5-phosphoribosyl pyrophosphate (PRPP) (7,8) .…”

Section: Introductionmentioning

confidence: 99%

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Serum Visfatin Levels and Coronary Artery Disease

Gürsoy¹,

Duygu²,

Hökenek³

et al. 2014

Khj

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Introduction: Adipose tissue is not only source of energy but also an active endocrine organ serving function by secreting bioactive molecules called adipokines. Visfatin is a recently discovered adipokine and is proposed to play role in inflammatory and atherosclerotic states. We aimed to investigate the association of visfatin with coronary artery disease (CAD). Patients and Methods: Twenty patients undergoing coronary artery bypass grafting due to CAD were compared with 20 individuals without CAD angiographically. Gender, age, body mass index, and serum visfatin levels were compared between the two groups. Relationship of visfatin levels and severity of CAD, cross-clamp and cardiopulmonary bypass times were also investigated in the study group. Results: Age, gender, BMI, and blood pressures were not significantly different between the groups. There was significant difference in serum visfatin levels between the two groups (47.31±33.03 ng/mL and 9.04±7.18 ng/mL, p=0.0001). A strong correlation between the Gensini score and pre-operative visfatin levels (r=0.81; p=0.0001) was observed for the study group. No correlation was detected between the visfatin level and cardiopulmonary bypass and cross clamp times. Conclusion: Increased visfatin levels may be associated with inflammation and atherosclerotic cardiovascular diseases. Circulating visfatin level is increased in patients undergoing coronary artery bypass grafting. Further studies are warranted to determine the predictive value of serum visfatin as a biomarker and potential therapeutic target for metabolic and cardiovascular diseases. Key Words: Adipose tissue; adipokine; visfatin; atherosclerosis; coronary artery disease Giriş: Yağ dokusu yalnızca enerji kaynağı olmayıp aynı zamanda adipokin olarak adlandırılan biyoaktif maddeleri salgılayan bir endokrin organdır. Visfatin son dönemlerde keşfedilen, inflamasyon ve ateroskleroz ile ilişkilendirilen bir adipokindir. Bu çalışmada visfatinin koroner arter hastalığı ile ilişkisini araştırmayı amaçladık. Hastalar ve Yöntem: Koroner arter hastalığı sebebiyle koroner arter baypas greftleme planlanan 20 hasta anjiografik olarak koroner arter hastalığı olmayan 20 bireyle kıyaslandı. Cinsiyet, yaş, vücut kitle indeksi ve serum visfatin seviyesi gruplar arasında karşılaştırıldı. Visfatin seviyesinin koroner arter hastalığının ciddiyeti, aortic kros klemp zamanı ve kardiyopulmoner baypas zamanı ile ilişkisi de incelendi. Bulgular: Gruplar arasında yaş, cinsiyet, vücut kitle indeksi ve kan basınçları arasında fark saptanmadı. Serum visfatin seviyeleriyse anlamlı farklı bulundu (47,31±33,03 ng/ml ve 9,04±7,18 ng/ml, p=0,0001). Gensini skoru ile preoperative visfatin seviyesi arasında güçlü korelasyon saptandı (r=0,81; p=0,0001). Visfatin seviyesi ile kardiyopulmoner baypas ve aortic kros klemp zamanı arasında ilişki saptanmadı. Sonuç: Artmış serum visfatin seviyesi inflamasyon ve aterosklerotik kardiyovasküler hastalıklarla ilişkili olabilir. Dolaşımdaki visfatin seviyesi koroner arter baypas greftleme yapılan hastalarda...

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Common mechanisms of dysfunctional adipose tissue and obesity‐related cancers

Matafome

Santos-Silva

Sena

et al. 2013

Diabetes Metabolism Res

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The relation between cancer and metabolic disorders was recognized several decades ago, but the underlying mechanisms involved in cancer development and progression remain obscure. In the last years, many groups have been studying systemic adipose tissue markers in cancer patients. However, few consistent results were obtained. On the other hand, several studies revealed many aspects of adipose tissue physiology in obesity. Nowadays, it is recognized that excessive lipid uptake in adipocytes leads to hypertrophy and consequently to metabolic dysregulation, hypoxia, inflammation, impaired adipocytokine expression and angiogenesis, insulin resistance and macrophage recruitment. In obese patients, tumours commonly colocalize with excessive adipose tissue accumulation, and most of the features of hypertrophic adipose tissue are observed in cancer patients, namely breast and colon. This review aimed to summarize pathological adipose tissue alterations that may contribute to cancer aetiology and development.

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Plasma visfatin and retinol binding protein-4 levels in patients with type 2 diabetes mellitus and their relationship to adiposity and fatty liver

Cited by 41 publications

References 49 publications

Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus

Serum Visfatin Levels and Coronary Artery Disease

Common mechanisms of dysfunctional adipose tissue and obesity‐related cancers

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