Plasma surface modification of powders for pharmaceutical applications

Roth, Christian; Künsch, Zaira; Sonnenfeld, Axel; Rohr, Philipp Rudolf von

doi:10.1016/j.surfcoat.2010.10.046

Cited by 34 publications

(25 citation statements)

References 13 publications

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“…The total surface area increases with smaller particle diameter leading to longer processing times. To expose the whole surface of each polymer particle to a plasma various concepts have been explored, including vibration, rotation, conveying, fluidization, and agitation by mechanical stirring (see Figure ) . All concepts have in common that the powders have to be in motion to achieve a uniform plasma treatment.…”

Section: Reactor Design Considerationsmentioning

confidence: 99%

“…The DBD treatment volume in the discharge gap is rather small in comparison to low‐pressure plasmas. Thus, if powder is transported through these small volumes, the cohesive attraction among powder particles along with moderate melting temperatures and particle‐plasma interactions may lead to undesired wall depositions and can provoke equipment clogging …”

Section: Reactor Design Considerationsmentioning

confidence: 99%

“…As visualized in Figure , plasma‐polymer interactions (i.e., a powder particle) may be classified into the following surface modification groups: (1) etching/cleaning, (2) surface functionalization/activation, (3) film deposition/coating by plasma polymerization, and (4) spacer deposition . During etching or cleaning, the polymer surface is exposed to positive ions, UV radiation, and reactive neutrals.…”

Section: Introductionmentioning

confidence: 99%

“…The deposition of plasma‐generated nanoparticles (e.g., SiO 2 ) as spacers on polymer particle surfaces in a single process step is another promising functionality, e.g., to improve powder flowability by reducing inter‐particular van der Waals forces …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Plasma treatment of polymer powders – from laboratory research to industrial application

Arpagaus

Oberbossel

Rohr

2018

Plasma Processes & Polymers

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This review provides a comprehensive overview of scientific research on plasma treatment of polymer powders over the last 40 years. The current state of the art is described with special focus on basic research in the laboratory and commercially available technologies in industrial applications. Different reactor systems with low‐pressure and atmospheric pressure plasma are presented. Then, numerous application examples of plasma‐treated polymer powders are presented together with a brief overview of the experimental test results. Furthermore, the effects of the process parameters on the final properties of the polymer powders are discussed. Attempts are made to determine similarity parameters and correlations between the generated surface functionalities. Finally, some suggestions for future research are given.

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Section: Reactor Design Considerationsmentioning

confidence: 99%

Section: Reactor Design Considerationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Plasma treatment of polymer powders – from laboratory research to industrial application

Arpagaus

Oberbossel

Rohr

2018

Plasma Processes & Polymers

Self Cite

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“…The application of plasma processes for modification of polymer micro‐sized particles and spheres are widely used in biotechnology, cosmetics, coatings, and composites . These surfaces are often non‐planar and rough, as in tissue scaffolding and drug delivering micro‐beads .…”

Section: Plasma‐based Surface Treatmentmentioning

confidence: 99%

Hybrid and Fluid Modeling of Ion Activation Energy and Reactive Fluxes to Particulates Suspended in Air and Residing on Surfaces

Babaeva

2016

Plasma Processes & Polymers

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We report on a computational study of the intersection of plasma filaments in a dielectric barrier discharge with small particulates suspended in air or residing on surfaces. The relative location of the particle with respect to the streamer axis is important on plasma time scale considered in the paper. The particulates residing on the substrate surface are partially enveloped by the sheath formed beneath the filament and the substrate. Ion energies and fluxes incident on the particulate depend on dielectric properties of the underlying substrate materials.

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Multiscale Aspects of Modeling Gas‐Phase Nanoparticle Synthesis

Buesser

Gröhn

2012

Chem Eng & Technol

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Aerosol reactors are utilized to manufacture nanoparticles in industrially relevant quantities. The development, understanding and scale-up of aerosol reactors can be facilitated with models and computer simulations. This review aims to provide an overview of recent developments of models and simulations and discuss their interconnection in a multiscale approach. A short introduction of the various aerosol reactor types and gas-phase particle dynamics is presented as a background for the later discussion of the models and simulations. Models are presented with decreasing time and length scales in sections on continuum, mesoscale, molecular dynamics and quantum mechanics models.

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Plasma surface modification of powders for pharmaceutical applications

Cited by 34 publications

References 13 publications

Plasma treatment of polymer powders – from laboratory research to industrial application

Plasma treatment of polymer powders – from laboratory research to industrial application

Hybrid and Fluid Modeling of Ion Activation Energy and Reactive Fluxes to Particulates Suspended in Air and Residing on Surfaces

Multiscale Aspects of Modeling Gas‐Phase Nanoparticle Synthesis

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