volume 27, issue 2, P259-269 2011
DOI: 10.3233/jad-2011-110405
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Michelle M. Mielke, Norman J. Haughey, Veera Venkata Ratnam Bandaru, Danielle D. Weinberg, Eveleen Darby, Noman Zaidi, Valory Pavlik, Rachelle S. Doody, Constantine G. Lyketsos

Abstract: Plasma sphingolipids have been shown to predict cognitive impairment and hippocampal volume loss, but there is little research in patients with Alzheimer’s disease dementia (AD). In this study we sought to determine whether plasma ceramides, dihydroceramides (DHCer), sphingomyelins (SM), or dihydrosphingomyelin (DHSM) levels and ratios of SM/ceramide or DHSM/DHCer were predictive of progression in AD. Probable AD patients (n=120) were enrolled in the Alzheimer’s Disease and Memory Disorders Center at Baylor C…

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