Plasma Proteins in Various Diseases of the Skin

Lever, Walter F.; Schultz, Ethel L.; Hurley, Nancy A.

doi:10.1001/archderm.1951.01570060030003

Cited by 36 publications

(4 citation statements)

References 30 publications

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“…A return to a normal distribution of the components, occasionally with the relative concentration of the y-globulin somewhat below the normal concentration, may occur when the remission is relatively complete (see Cases 1, 4, and 5, Table IV). Similar observations have been reported by other workers in rheumatoid arthritis (9,12,15,38,39), as well as in rheumatic fever (7,35,40), disseminated lupus erythematosus (41,42), and scleroderma (42).…”

Section: Resultssupporting

confidence: 89%

“…The albumin contents in these two cases were 34 and 24 per cent. Coburn and Moore (46) in two patients, Walker and Benditt (47) in nine, and Lever, Schultz, and Hurley (42) in nine noted similar patterns with slight or no abnormality in the aglobulin fractions and slight to marked elevation of y-globulin. The distribution found by Reiner (41) in five cases was similar except for considerable increase in a2-globulin.…”

Section: Addendum Electrophoretic Distribution Of Proteins In Plasmamentioning

confidence: 81%

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The Electrophoretic Distribution of Proteins in Plasma in Rheumatoid Arthritis12

Ropes¹,

Perlmann²,

Kaufman³

et al. 1954

J. Clin. Invest.

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Abnormalities in the electrophoretic patterns of plasma proteins in rheumatoid arthritis have been described by various workers. With few exceptions an increase in the relative concentration of a,-, a2-, and y-globulin and of fibrinogen and lowering of the albumin concentration have been observed and have been associated consistently with activity of the disease (1-15). Olhagen (4, 10) and Svartz and Olhagen (8) ascribed a possible prognostic significance to isolated elevation of a-or y-globulin. They suggested that an elevation of the a-globulins without an increase in the y-fraction, often noted in acute cases, indicated a tendency to more rapid healing, whereas a high y-globulin with low a-globulins represented a poor prognosis. Wallis (13) described a "T component" in three patients with active rheumatoid arthritis. A protein with a similar electrophoretic mobility, y'-globulin, was noted by Paul and Routh (14) in normal sera. These authors observed a small decrease of this fraction in the sera of seven patients with rheumatoid spondylitis but found no change in 27 patients with generalized rheumatoid arthritis. Recently, Laurell (16) and Mehl and Golden (17) have demonstrated the occurrence of small amounts of two proteins with isoelectric pH values lower than that of serum albumin when electrophoresis was performed in acetate buffer of pH 4.5. The concentration of one component, which at pH 8.6 in diethylbarbiturate migrates with a mobility of the a2-globulin, was considerably increased in sera from patients with rheumatoid arthritis (17) and disappeared on treatment with cortisone (16).

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Section: Resultssupporting

confidence: 89%

Section: Addendum Electrophoretic Distribution Of Proteins In Plasmamentioning

confidence: 81%

The Electrophoretic Distribution of Proteins in Plasma in Rheumatoid Arthritis12

Ropes¹,

Perlmann²,

Kaufman³

et al. 1954

J. Clin. Invest.

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“…All these changes may result in the sudden release of inflammatory cells, RBCs, fibronectine, fibrin and other materials that get mixed with some of the acantholytic cells, cells altering that microbalance. The plasma proteins in various ABDs have been described to be altered [11]. This may produce alterations in the blood flow, and may result in rouleaux formation, with or without autoagglutination, clumpled with lysed cells and extravasation of molecules.…”

Section: Discussionmentioning

confidence: 99%

Rouleaux, autoaglutinitation of erythrocytes associated with a pinkish material resembling fibrin-like agregate material in the in skin biopsies from patients with autoimmune blistering disease

Velez¹,

Smoller²,

Howard³

2013

Our Dermatol Online

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Introduction: Autoimmune bullous skin diseases (ABDs) represent a heterogeneous group of disorders of the skin and mucosa; these disorders are commonly associated with deposits of immunoglobulins, complement, and fibrinogen, usually directed against distinct adhesion molecules. Methods: We utilized hematoxylin and eosin (H & E) stained tissues sections to evaluate for the presence of rouleaux in lesional skin biopsies of patients affected by ABDs including patients with endemic and nonendemic pemphigus foliaceus, bullous pemphigoid (BP), pemphigus vulgaris (PV), dermatitis herpetiformis (DH), and a group of controls taken from routine biopsies seen in our practice. Results: Most autoimmune bullous skin diseases biopsies showed rouleaux formation within and around post-capillary venules in the superficial vascular plexus in association with a pinkish brush-like material that resembles fibrin or other amorphous eosinophilic material. Discussion: We document that rouleaux and the pinkish aggregates are present in within biopsies taken from lesional skin in the majority of patients with ABDs and speculate that this maybe as result of the exocytosis of inflammatory cells, antibodies that form when exposed to the extracellular matrix which is already edematous in most ABDs. In addition red blood cells in the presence of plasma proteins or other macromolecules may form aggregates. Further studies are needed.

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“…IMMUNOGLOBULTN abnormalities in psoriasis have in the past been described semi-quantitatively either by scanning electrophoresis strips (Lever et al, 1951;Feldaker et al, 1956;Tickner et al, 1959) or by the degree of precipitation in immunoelectrophoresis (Lim and Fusaro, 1962;Krebs et al, 1963;Kaldor, 1965). Recently Fraser et al (1969), using the gel diffusion technique devised by Fahey and MacKelvey (1965), determined quantitatively the serum IgG-, IgA-and IgM-globulins in a study of dermatitis herpetiformis (DH) and various other skin diseases.…”

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confidence: 99%

Serum Immunoglobulins in Psoriasis Before and After Ultra Violet Light Therapy

Varelzidis

Theodoridis

2006

British Journal of Dermatology

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SUMMARY.— A significant increase of the mean IgA globulin value was noted in 105 patients with ordinary psoriasis whereas the mean IgG and IgM globulin levels remained normal. Thirty‐two of these patients received u.v. light therapy which resulted in resolution of the skin lesions. At this stage the IgA levels fell to the normal range. The possibility of the skin eruption influencing the IgA serum levels is discussed.

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Plasma Proteins in Various Diseases of the Skin

Cited by 36 publications

References 30 publications

The Electrophoretic Distribution of Proteins in Plasma in Rheumatoid Arthritis12

The Electrophoretic Distribution of Proteins in Plasma in Rheumatoid Arthritis12

Rouleaux, autoaglutinitation of erythrocytes associated with a pinkish material resembling fibrin-like agregate material in the in skin biopsies from patients with autoimmune blistering disease

Serum Immunoglobulins in Psoriasis Before and After Ultra Violet Light Therapy

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