Plasma prolactin response to thyrotropin releasing hormone in children with newly diagnosed insulin dependent diabetes.

Abe, Kazuo; Matsuura, Nobuo; Fukushima, Naoki; Nohara, Yoshitsugu; Fujita, Hiroko; Fukui, Kenji; Katō, Takako

doi:10.1620/tjem.140.29

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…There is, however, relatively little information on the PRL response to TRH in children (Foley et al 1972;Kaplan et al 1972;Okada et al 1978 ;Suter et al 1978 ;Roitman et al 1980;Abe et al 1982Abe et al , 1983). Since it has been known that PRL plays some role for breast development (Frantz 1981) …”

mentioning

confidence: 99%

Prolactin response to thyrotropin-releasing hormone in children with gynecomastia, premature thelarche and idiopathic precocious puberty.

Abe

Matsuura

Nohara

et al. 1984

Tohoku J. Exp. Med.

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mentioning

confidence: 99%

Prolactin response to thyrotropin-releasing hormone in children with gynecomastia, premature thelarche and idiopathic precocious puberty.

Abe

Matsuura

Nohara

et al. 1984

Tohoku J. Exp. Med.

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“…In a cohort of 42 women with T1DM, daily insulin dose, fasting glycemia, HbA1c values and median age correlated negatively with PRL levels 48 . Contrasting results have been also found in studies involving T1DM patients, which have analysed the response of PRL levels after stimulation with thyrotropin releasing hormone (TRH) 49,50 . These heterogenous findings can be due to several factors, which may influence PRL homeostasis, including hormones, neurotransmitters, cytokines as well as circadian rhythm 16 …”

Section: Prolactin Effects On Pancreatic β‐Cellsmentioning

confidence: 97%

“…48 Contrasting results have been also found in studies involving T1DM patients, which have analysed the response of PRL levels after stimulation with thyrotropin releasing hormone (TRH). 49,50 These heterogenous findings can be due to several factors, which may influence PRL homeostasis, including hormones, neurotransmitters, cytokines as well as circadian rhythm. 16 It is worth mention that PRL secretion is greatly influenced by the control of the underlying disease.…”

Section: ↑ βCells Mass and Insulin Secretion During Pregnancy Mousementioning

confidence: 99%

Prolactin effects on the pathogenesis of diabetes mellitus

Scairati,

Auriemma,

Del Vecchio

et al. 2024

Eur J Clin Investigation

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BackgroundProlactin (PRL) is a pituitary hormone promoting lactation in response to the suckling reflex. Beyond its well‐known effects, novel tissue‐specific and metabolic functions of PRL are emerging.AimsTo dissect PRL as a critical mediator of whole‐body gluco‐insulinemic sensitivity.MethodsPubMed‐based search with the following terms ‘prolactin’, ‘glucose metabolism’, ‘type 2 diabetes mellitus’, ‘type 1 diabetes mellitus’, ‘gestational diabetes mellitus’ was performed.DiscussionThe identification of the PRL‐glucose metabolism network poses the basis for unprecedented avenues of research in the pathogenesis of diabetes mellitus type 1 or 2, as well as of gestational diabetes. In this regard, it is of timely relevance to define properly the homeostatic PRL serum levels since glucose metabolism could be influenced by the circulating amount of the hormone.ResultsThis review underscores the basic mechanisms of regulation of pancreatic β‐cell functions by PRL and provides a revision of articles which have investigated the connection between PRL unbalancing and diabetes mellitus. Future studies are needed to elucidate the burden and the role of PRL in the regulation of glucose metabolism and determine the specific PRL threshold that may impact the management of diabetes.ConclusionA careful evaluation and context‐driven interpretation of PRL levels (e.g., pregnancy, PRL‐secreting pituitary adenomas, drug‐related hyper‐ and hypoprolactinemia) could be critical for the correct screening and management of glucometabolic disorders, such as type 1 or 2 as well as gestational diabetes mellitus.

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“…Basal and TRH-induced TSH secretions were normal, whereas plasma T3 and T4 concentrations were significantly lower in patients than in controls. 210 Thyroid autoimmunity was evaluated in 92 hyperprolactinemic patients, 4 of whom had acromegaly. High titers of thyroglobulin and microsomal antibodies were found in 1 acromegalic, and in 12 women with either adenomatous or idiopathic hyperprolactinemia.…”

Section: Prolactin and Diseasementioning

confidence: 99%

The Immunology of Prolactin

Berczi¹

1992

Semin Reprod Med

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Plasma prolactin response to thyrotropin releasing hormone in children with newly diagnosed insulin dependent diabetes.

Cited by 6 publications

References 12 publications

Prolactin response to thyrotropin-releasing hormone in children with gynecomastia, premature thelarche and idiopathic precocious puberty.

Prolactin response to thyrotropin-releasing hormone in children with gynecomastia, premature thelarche and idiopathic precocious puberty.

Prolactin effects on the pathogenesis of diabetes mellitus

The Immunology of Prolactin

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