Plasma Oxidative Stress and Total Thiol Levels in Crimean-Congo Hemorrhagic Fever

Karadağ‐Öncel, Eda; Erel, Özcan; Özsürekçi, Yasemin; Çağlayık, Dilek Yağcı; Kaya, Ali; Gözel, Mustafa Gökhan; İçağasıoğlu, Füsun Dilara; Engin, Aynur; Korukluoğlu, Gülay; Uyar, Yavuz; Elaldı, Nazif; Ceyhan, Mehmet

doi:10.7883/yoken.67.22

Cited by 20 publications

(20 citation statements)

References 26 publications

(33 reference statements)

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“…In this study it was ascertained that native thiol levels, though insignificant, proved to be lower in the patient population. In the previously conducted studies, it was shown that native thiol level decreased in the presence of infections such as brucellosis as well as Crimean-Congo haemorrhagic fever and viral and bacterial tonsillopharyngitis [8,22,23]. The results of present study are in agreement with the studies in the literature.…”

Section: Discussionsupporting

confidence: 92%

Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis

Desdicioğlu¹

2018

JGO

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This study investigated the thiol-disulphide balance in vaginitis, which is a local inflammatory condition, through the use of a new method. A cross-sectional study involving 82 women (45 women with vaginitis and 37 women in control group) was conducted at Ataturk Education and Research Hospital, Ankara, Turkey from February 2016 to April 2016. Their ages varied between 19-75 years (mean: 42.8±11.6), were incorporated into the study. Thiol-disulphide parameters were measured and the obtained results were compared. The results showed that the serum disulphide level and disulphide/native thiol ratio in the group with vaginitis (p = 0.03 and p = 0.04) and the native thiol/total thiol ratio in the control group was higher (p = 0.03). In this study, it was shown that serum dynamic thiol-disulphide balance in the women with vaginitis had varied. Although vaginitis is a localized infectious inflammatory condition, the increase in the systemic oxidative stress is important. This study is the first article in the literature that investigates the relationship between dynamic thiol-disulphide balance and vaginitis.

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Section: Discussionsupporting

confidence: 92%

Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis

Desdicioğlu¹

2018

JGO

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“…Oxidative stress is evaluated as responsible for the etiopathogenesis and pathophysiology of many diseases (7)(8)(9). Reactive oxygen species (ROS) production occurs immediately after exposure to oxidative stress and hypoxia.…”

Section: Discussionmentioning

confidence: 99%

Level of Certain Oxidants and Antioxidants in Patients with Uterine Fibroids

Çetinkaya

Ayral

Çeti̇nkaya

et al. 2019

Gynecol Obstet Reprod Med

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Objective: The mechanism of the leiomyoma formation process is still unknown. However, the menstrual cycle is associated with hypoxia, and ongoing hypoxia is associated with cellular events leading to the conversion of myometrial cells into uterine fibroids. After the hypoxic environment, the balance of cellular cytokines and growth factors changes. It was planned to evaluate the balance of oxidative agents and the role of oxidative stress in the formation of uterine fibroids.Study Design: The study was conducted in patients of gynecology outpatient clinic of Ankara Oncology Training and Research Hospital. Those volunteers with fibroids formed the study group, and the healthy ones were identified as the control group. A total of 64 subjects, 32 in both groups were included. The levels of catalase, ceruloplasmin, myeloperoxidase, native thiol, disulfide, and total thiol levels were investigated in groups.Results: Antioxidant parameters such as native thiol, disulfide, and total thiol levels were significantly decreased in uterine fibroid group. Catalase, ceruloplasmin, and myeloperoxidase levels were not statistically different between groups.Conclusion: Decrease in these antioxidant parameters showed that the hypoxia and the balance of oxidant and antioxidant substances changes may probably have associated with the pathophysiology of uterine fibroids.

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“…ratio between TOS and TAS indicating disturbance in antioxidant status which may contribute to hepatic degenerative changes. 32 Cellular antioxidant defense consists of non-enzymatic (thiols, antioxidants, etc) and enzymatic (CAT, SOD, GPx, GST) components, which contributes a crucial role in free radicals induced cellular damage. Reduction in levels of TTH and activities of antioxidant enzymes on APAP administration indicates reduction in level of TAS.…”

Section: Discussionmentioning

confidence: 99%

Acetaminophen Induced Oxidative and Histopathological Alterations in Hepatic Tissue: Protective Effects of Alstonia Scholaris Leaf Extracts

Verma¹,

Raina²,

Sultana³

et al. 2016

Phcogj

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Introduction: Alstonia scholaris Linn. is the common ingredients of various herbal formulation. Objectives: Present study was aimed to evaluate the oxidative and histopathological alterations in acetaminophen (APAP) induced hepatotoxicity and protective mechanisms of different leaf extracts of A. scholaris. Methods: Forty two wistar rats were randomly divided into seven groups with six rats in each and subjected to different treatments. Alterations in total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), total thiols (TTH), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-s-transferase (GST), malondialdehyde (MDA) levels and histopathological alterations in hepatic tissue were analyzed to assess the extent of hepatic damage induced by APAP and the protection imparted against it by aqueous or ethanolic leaf extract of A. scholaris. Results: Single high oral dose of APAP administration increased (p<0.05) hepatic levels of TOS, OSI and MDA and reduced TAS, TTH, SOD, CAT, GPx and GST activities indicating alteration in antioxidant system of hepatic tissue. The histopathological studies showed severe hepatic degeneration, vacuolization and granulation in cytoplasm, fragmentation of nuclei and membranes and infiltration of mononuclear cells on APAP treatment. Pre and post-treatments of aqueous or ethanolic extract following APAP administration restored TTH, reduced MDA and TOS and increased TAS compared to APAP treatment alone. Conclusions: Observations of histopathological and antioxidant parameters indicates that restoration of TAS and TTH levels by leaf extracts may be the primary protective mechanism in APAP induced hepatotoxicity. Further treatments with ethanolic extract showed more hepatoprotective potential than the aqueous extract of A. scholaris.

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Plasma Oxidative Stress and Total Thiol Levels in Crimean-Congo Hemorrhagic Fever

Cited by 20 publications

References 26 publications

Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis

Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis

Level of Certain Oxidants and Antioxidants in Patients with Uterine Fibroids

Acetaminophen Induced Oxidative and Histopathological Alterations in Hepatic Tissue: Protective Effects of Alstonia Scholaris Leaf Extracts

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