Plasma metal concentrations and their interactions with genetic susceptibility on homocysteine levels

Long, Pinpin; Wang, Hao; Zhang, Zirui; Li, Wending; Zhang, Yizhi; He, Shiqi; Yu, Kuai; Jiang, Haijing; Liu, Xuezhen; Guo, Huan; He, Meian; Zhang, Xiaomin; Wu, Tangchun; Yuan, Yu

doi:10.1016/j.ecoenv.2022.113705

Cited by 4 publications

(2 citation statements)

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“…The genotyping arrays used in this study were Illumina Infinium OmniZhongHua-8 chips. Detailed information on the genotyping process was described elsewhere . The reference panel in genotype imputation was 3931 samples of individuals with East Asian heritage from the 1000 Genomes Project phase III and the SG10K Project.…”

Section: Methodsmentioning

confidence: 99%

“…Detailed information on the genotyping process was described elsewhere. 24 The reference panel in genotype imputation was 3931 samples of individuals with East Asian heritage from the 1000 Genomes Project phase III and the SG10K Project. The single-nucleotide variations (SNVs) selected for calculating the polygenic risk scores (PRS) for CHD and stroke were from the recently published and validated CHD PRS 25 (comprising 540 SNVs) and stroke PRS 26 (comprising 534 SNVs); of these SNVs, 533 SNVs for CHD (eTable 1 in Supplement 1 ) and 527 SNVs for stroke (eTable 2 in Supplement 1 ) reached the criteria of a call rate greater than 95%, minor allele frequency greater than 0.001, P value greater than 1 × 10 −6 in Hardy-Weinberg equilibrium tests, and a mean R 2 imputation quality greater than 0.3 in the Dongfeng-Tongji cohort data.…”

Section: Methodsmentioning

confidence: 99%

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Changes in Sleep Patterns, Genetic Susceptibility, and Incident Cardiovascular Disease in China

Diao,

Liu,

Lyu

et al. 2024

JAMA Netw Open

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ImportanceThe associations of changes in sleep patterns with incident cardiovascular disease (CVD) are not fully elucidated, and whether these associations are modified by genetic susceptibility remains unknown.ObjectivesTo investigate the associations of 5-year changes in sleep patterns with incident CVD and whether genetic susceptibility modifies these associations.Design, Setting, and ParticipantsThis prospective cohort study of the Dongfeng-Tongji cohort was conducted from 2008 to 2018 in China. Eligible participants included those with complete sleep information at baseline survey (2008-2010) and the first follow-up survey (2013); participants who had no CVD or cancer in 2013 were prospectively assessed until 2018. Statistical analysis was performed in November 2023.ExposuresFive-year changes in sleep patterns (determined by bedtime, sleep duration, sleep quality, and midday napping) between 2008 and 2013, and polygenic risk scores (PRS) for coronary heart disease (CHD) and stroke.Main Outcomes and MeasuresIncident CVD, CHD, and stroke were identified from 2013 to 2018. Cox proportional hazards regression models were applied to estimate hazard ratios (HRs) and 95% CIs.ResultsAmong 15 306 individuals (mean [SD] age, 65.8 [7.4] years; 8858 [57.9%] female and 6448 male [42.1%]), 5474 (35.78%) had persistent unfavorable sleep patterns and 3946 (25.8%) had persistent favorable sleep patterns. A total of 3669 incident CVD cases were documented, including 2986 CHD cases and 683 stroke cases, over a mean (SD) follow-up of 4.9 (1.5) years. Compared with those with persistent unfavorable sleep patterns, individuals with persistent favorable sleep patterns over 5 years had lower risks of incident CVD (HR, 0.80; 95% CI, 0.73-0.87), CHD (HR, 0.84; 95% CI, 0.76-0.92), and stroke (HR, 0.66; 95% CI, 0.54-0.82) in the subsequent 5-year period. No significant effect modification by PRS was observed for sleep pattern change and CHD or stroke risk. However, sleep pattern changes and PRS were jointly associated with the CHD and stroke risk in a dose-dependent manner, with the lowest risk being among those with persistent favorable sleep patterns combined with low PRS (HR for CHD, 0.65; 95% CI, 0.52-0.82 and HR for stroke, 0.48; 95% CI, 0.29-0.79).Conclusions and RelevanceIn this cohort study of middle-aged and older Chinese adults, individuals with persistent favorable sleep patterns had a lower CVD risk, even among those with higher genetic risk. These findings highlight the importance of maintaining favorable sleep patterns for CVD prevention.

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Section: Methodsmentioning

confidence: 99%