Plasma membrane-associated superstructure: Have we overlooked a new type of organelle in eukaryotic cells?

Rodrı́guez-Fernández, José Luis; Lacoba, Mario Garcı́a de

doi:10.1016/j.jtbi.2015.05.029

Cited by 1 publication

(1 citation statement)

References 168 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on molecular and other features similarities between the diverse cellular protrusions, some authors have suggested that, despite differences in external appearances, all the regions of protrusions are just the same superstructure that appears in different locations and cells. They hypothesized that this superstructure represents an overlooked new type of organelle that they call plasma membrane-associated superstructure (PMAS) [121]. In an experimental study, the dynamics of cell shape and the distributions of actin and myosin in cells exhibiting cortical density traveling waves were investigated.…”

Section: Resultsmentioning

confidence: 99%

Insight on the role of RKIP in cancer through key protein partners and cellular protrusions

Schoentgen

2020

Prognostic and Therapeutic Applications of RKIP in Cancer

View full text Add to dashboard Cite

Previously, by comparing the cellular processes in which RKIP is implied and by analyzing the function of numerous molecular partners, we have suggested that RKIP may participate in regulating actin reorganization and membrane remodeling. Here, based on the role of RKIP in cancer, we describe the cellular function of five important partners of RKIP (GRK2, IQGAP, MT1-MMP, LC3 and Rab8). By their own activity, they may explain, at least in part, the multiple functions of RKIP as they are key actors in diverse cellular processes. All these proteins play a role in the formation or maturation of cellular protrusions such primary cilium, lamellipodia, filopodia or invadopodia. Considering the close relationship between actin cytoskeleton and membrane during cell migration, we suggest that a major role of RKIP in cells is likely to associate with main molecular assemblies, in order to drive the cortical actin/membrane complex in response to signaling pathways. In cancer cells, because of the lack of RKIP, this important regulation is lost.

show abstract

Section: Resultsmentioning

confidence: 99%

Insight on the role of RKIP in cancer through key protein partners and cellular protrusions

Schoentgen

2020

Prognostic and Therapeutic Applications of RKIP in Cancer

View full text Add to dashboard Cite

show abstract

Plasma membrane-associated superstructure: Have we overlooked a new type of organelle in eukaryotic cells?

Cited by 1 publication

References 168 publications

Insight on the role of RKIP in cancer through key protein partners and cellular protrusions

Insight on the role of RKIP in cancer through key protein partners and cellular protrusions

Contact Info

Product

Resources

About