Plasma long non-coding RNA <i>HOTAIR</i> as a potential biomarker for gastric cancer

Tayae, Eman; Salem, Perihan; Darwish, Azaa M; Fayed, Haytham

doi:10.1177/1724600818760244

Cited by 46 publications

(32 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…a recent study showed that serum HoTair could serve as a promising biomarker for diagnosing and monitoring non-small cell lung cancer (24). elsayed et al (25) concluded that plasma HoTair may serve as a potential non-invasive biomarker for the diagnosis of gastric cancer. Tan et al (26) demonstrated that serum HoTair could be used as a novel prognostic and diagnostic biomarker for glioblastoma multiforme.…”

Section: Discussionmentioning

confidence: 99%

Increased lncRNA HOTAIR expression promotes the chemoresistance of multiple myeloma to dexamethasone by regulating cell viability and apoptosis by mediating the JAK2/STAT3 signaling pathway

Guan

Wang

et al. 2019

Mol Med Report

View full text Add to dashboard Cite

Multiple studies have shown that HoX antisense intergenic rna (HoTair), an oncogenic long non-coding rna (lncrna), is dysregulated in leukemia and is involved in tumor progression. The aim of the present study was to determine whether HoTair could serve as a novel biomarker for the diagnosis of multiple myeloma (MM), and to investigate its role in regards to MM cell viability and chemoresistance to dexamethasone (deX). The results revealed that the expression of HOTAIR was significantly upregulated in serum, bone marrow and primary cd138 + cells from MM patients compared with those from normal controls as determined by qPcr. HoTair expression was obviously increased in MM cell lines compared to that in normal plasma cells. roc curve analysis showed that the serum level of HoTair exhibited a higher diagnostic value for MM. Furthermore, loss-of-functional assays indicated that HoTair inhibition suppressed MM cell viability by arresting the cell cycle at the G0/G1 phase as determined by cell viability assay and flow cytometry. an in-depth study revealed that knockdown of HoTair led to decreased chemoresistance of deX in MM cells by regulating the JaK2/STaT3 signaling pathway. Taken together, our findings suggest that upregulation of serum HoTair may prove to be a novel biomarker for the diagnosis of MM. HoTair promoted MM cell viability and increased chemoresistance of MM to deX via the JaK2/STaT3 signaling pathway, indicating HoTair may also serve as a potential therapeutic target for MM.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased lncRNA HOTAIR expression promotes the chemoresistance of multiple myeloma to dexamethasone by regulating cell viability and apoptosis by mediating the JAK2/STAT3 signaling pathway

Guan

Wang

et al. 2019

Mol Med Report

View full text Add to dashboard Cite

show abstract

“…In current years, multi-omics have developed rapidly with the application of high-throughput screening. Long non-coding RNA has drawn widespread attention as a prospective molecular target for cancer diagnosis and therapeutics [36][37][38]. Several studies have proposed that lncRNAs were involved in the immune process contributed to tumorigenesis and progression [39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of an immune long non-coding RNA signature in liver hepatocellular carcinoma

Kong

Wang

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: In recent years, long non-coding RNAs (lncRNAs) are emerging as crucial regulators in the immunological process of liver hepatocellular carcinoma (LIHC). Increasing studies have found that some lncRNAs could be used as a diagnostic or therapeutic target for clinical management, but little research has investigated the role of immune-related lncRNA in tumor prognosis. In this study, we aimed to develop an immune lncRNA signature for the precise diagnosis and prognosis of liver hepatocellular carcinoma. Methods: Gene expression profiles of LIHC samples obtained from TCGA were screened for immune-related genes using two reference gene sets. The optimal immune-related lncRNA signature was built via correlational analysis, univariate and multivariate cox analysis. Then the Kaplan-Meier plot, ROC curve, clinical analysis, gene set enrichment analysis, and principal component analysis were carried out to evaluate the capability of immune lncRNA signature as a prognostic indicator. Results: Six long non-coding RNA MSC−AS1, AC009005.1, AL117336.3, AL031985.3, AL365203.2, AC099850.3 were identified via correlation analysis and cox regression analysis considering their interactions with immune genes. Next, tumor samples were separated into two risk groups by the signature with different clinical outcomes. Stratification analysis showed the prognostic ability of this signature acted as an independent factor. The AUC value of ROC curve was 0.779. The Kaplan-Meier method was used in survival analysis and results showed a statistical difference between the two risk groups. The predictive performance of this signature was validated by principal component analysis (PCA). Data from gene set enrichment analysis (GSEA) further unveiled several potential biological processes of these biomarkers may involve in. Conclusion: In summary, the study demonstrated the potential role of the six-lncRNA signature served as an independent prognostic factor for LIHC patients.

show abstract

“…Human urothelial carcinoma-associated 1 (UCA1) is involved in gastric tumorigenesis and is increased in patients with GC [ 78 ]. Hox transcript antisense intergenic RNA (HOTAIR) is involved in gastric tumorigenesis [ 79 ], and it reportedly enhances GC cell growth and suppresses apoptosis [ 70 ]. Moreover, enhanced HOTAIR expression was related to higher grades, metastasis, and advanced tumor stages.…”

Section: Long Noncoding Rnas (Lncrnas)mentioning

confidence: 99%

“…Moreover, enhanced HOTAIR expression was related to higher grades, metastasis, and advanced tumor stages. Plasma HOTAIR levels were higher in GCs than in non-GCs [ 79 ].…”

Section: Long Noncoding Rnas (Lncrnas)mentioning

confidence: 99%

Non-Invasive Early Molecular Detection of Gastric Cancers

Yamamoto

Watanabe

Sato

et al. 2020

Cancers

View full text Add to dashboard Cite

Gastric cancer (GC) is a significant source of global cancer death with a high mortality rate, because the majority of patients with GC are diagnosed at a late stage, with limited therapeutic choices and poor outcomes. Therefore, development of minimally invasive or noninvasive biomarkers which are specific to GC is crucially needed. The latest advancements in the understanding of GC molecular landscapes and molecular biological methods have accelerated attempts to diagnose GC at an early stage. Body fluids, including peripheral blood, saliva, gastric juice/wash, urine, and others, can be a source of biomarkers, offering new methods for the early detection of GC. Liquid biopsy-based methods using circulating sources of cancer nucleic acids could also be considered as alternative strategies. Moreover, investigating gastric juices/washes could represent an alternative for the detection of GC via invasive biopsy. This review summarizes recently reported biomarkers based on DNA methylation, microRNA, long noncoding RNA, circular RNA, or extracellular vesicles (exosomes) for the detection of GC. Although the majority of studies have been conducted to detect these alterations in advanced-stage GC and only a few in population studies or early-stage GC, some biomarkers are potentially valuable for the development of novel approaches for an early noninvasive detection of GC.

show abstract

Plasma long non-coding RNA HOTAIR as a potential biomarker for gastric cancer

Abstract: Plasma HOTAIR might serve as a potential non-invasive biomarker for diagnosis of gastric cancer.

Cited by 46 publications

References 42 publications

Increased lncRNA HOTAIR expression promotes the chemoresistance of multiple myeloma to dexamethasone by regulating cell viability and apoptosis by mediating the JAK2/STAT3 signaling pathway

Increased lncRNA HOTAIR expression promotes the chemoresistance of multiple myeloma to dexamethasone by regulating cell viability and apoptosis by mediating the JAK2/STAT3 signaling pathway

Prognostic value of an immune long non-coding RNA signature in liver hepatocellular carcinoma

Non-Invasive Early Molecular Detection of Gastric Cancers

Contact Info

Product

Resources

About