Plasma lipid and lipoprotein concentrations in pregnancy induced hypertension

Çekmen, Mustafa; Erbağcı, Ahmet; Balat, Ayşe; Duman, Can; Maral, Hale; Ergen, Kıvanç; Ozden, Meltem; Balat, Özcan; Kuşkay, Sevinç

doi:10.1016/s0009-9120(03)00099-7

Cited by 80 publications

(73 citation statements)

References 8 publications

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“…Serum TG concentration increases much more significantly in pre-eclamptic pregnancy. Our study also corroborated with the findings of Equobohrie et al, [14] and Cekmen et al, [18].…”

Section: Discussionsupporting

confidence: 93%

Association of Lipid Profile and Uric Acid with Pre-Eclampsia of Third Trimester in Nullipara Women

Agarwal

Gupta

Vishnu

et al. 2014

JCDR

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“…Serum TG concentration increases much more significantly in pre-eclamptic pregnancy. Our study also corroborated with the findings of Equobohrie et al, [14] and Cekmen et al, [18].…”

Section: Discussionsupporting

confidence: 93%

Association of Lipid Profile and Uric Acid with Pre-Eclampsia of Third Trimester in Nullipara Women

Agarwal

Gupta

Vishnu

et al. 2014

JCDR

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“…During pregnancy, serum lipoproteins except HDL-C increase considerably 17 and are two-to threetimes higher in PIH. Worldwide, various studies 5,[18][19][20][21][22][23][24] have reported elevated lipid levels in PIH subjects similar to our observations. In the present study, TC was significantly increased (p <0.01) in PIH subjects compared to control subjects consistent with other studies.…”

Section: Discussionsupporting

confidence: 90%

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Saxena¹,

Thimmaraju²,

Srivastava³

et al. 2015

J Clin Sci Res

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Background: Pregnancy induced hypertension (PIH) contributes greatly to maternal morbidity and mortality. Altered lipid profile and increased lipid peroxidation activate endothelial dysfunction and atherothrombosis leading to PIH. Therefore, estimation of lipid profile with serum malondialdehyde (MDA) in pregnancy may be helpful in predicting the development of PIH and further progression. Material and methods:In this prospective case-control study, serum lipid profile and MDA were estimated in 70 PIH subjects with gestational hypertension, pre-eclampsia, eclampsia; and 70 normotensive pregnant women aged 18 -40 years, with gestational age of over 20 weeks.Results: A statistically significant higher serum total cholesterol, very low density lipoprotein cholesterol (VLDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), TC/HDL-C, LDL-C/HDL-C and MDA, and a significantly lower HDL-C was noted in PIH subjects as compared to control subjects. When compared with the severity of PIH, all the lipoproteins (except HDL-C) along with MDA were found to be higher in women with eclampsia when compared with gestational hypertension, pre-eclampsia and normotensive pregnant women. Conclusions:An abnormal lipid metabolism along with oxidative stress may add to the promotion of vascular dysfunction leading to PIH. Lipoproteins and MDA alter significantly in eclampsia. Therefore, during pregnancy, early diagnosis and management of dyslipidaemia may prevent lipid peroxidation and progression of PIH thereby preventing obstetric complications.

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“…Though in our own study, the mean value of HDL-C was about 30% higher in the third trimester of normal pregnancy over the nonpregnant women, but statistically the alteration was not significant (P>0.05). A tendency to lesser quantities of serum alpha lipoprotein fraction in women with toxaemia, particularly in the third trimester, was reported by many workers (6,7,9). In our study a significant decrease in HDL-C were observed in pre-eclamptic and eclamptic pregnant women.…”

Section: Resultssupporting

confidence: 78%