Plasma immunoreactive melanotrophic hormones in patients on maintenance haemodialysis.

Gilkes, J. J. H.; Eady, R.A.J.; Rees, Lesley; Munro, D.D.; Moorheàd, J. F.

doi:10.1136/bmj.1.5959.656

Cited by 66 publications

(17 citation statements)

References 13 publications

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“…It has been suggested that they may be due to increased melanogenesis as a result of high tissue levels of beta melanin-se creting hormone, which is poorly dialyzable [23].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Abnormalities in Uremic Patients

Bencini¹,

Montagnino

Citterio

et al. 1985

Nephron

134

104

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94 uremic patients, 68 on regular hemodialysis treatment (RHT) and 26 on chronic ambulatory peritoneal dialysis (CAPD), were followed for up to 20 months in search of dermatological manifestations. 79% of RHT and 76% of CAPD patients had some kind of cutaneous lesion. The most characteristic features of cutaneous involvement in RHT and CAPD patients were: cutaneous xerosis, pruritus, infectious manifestations and disorders of pigmentation. In 4 RHT patients, precancerous and cancerous manifestations were also observed.

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“…It has been suggested that they may be due to increased melanogenesis as a result of high tissue levels of beta melanin-se creting hormone, which is poorly dialyzable [23].…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Abnormalities in Uremic Patients

Bencini¹,

Montagnino

Citterio

et al. 1985

Nephron

134

104

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“…In the present study, we have investigated the concentrations and relative plasma distributions of immunoreactive h,3LPH, hyLPH, and h,8END in normal subjects, in patients undergoing hemodialysis because of chronic renal failure, a condition that is associated with high plasma "h,BMSH" immunoreactivity (30)(31)(32), and in patients with syndromes associated with ACTH/LPH hypersecretion. The plasma disappearance rates of the three endogenous peptides have also been studied in a patient with Addison's disease.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Assay of Immunoreactive β-Lipotropin, γ-Lipotropin, and β-Endorphin in Plasma of Normal Human Subjects, Patients with ACTH/Lipotropin Hypersecretory Syndromes, and Patients undergoing Chronic Hemodialysis

Bertagna¹,

Stone²,

Nicholson³

et al. 1981

J. Clin. Invest.

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“…Diffuse hyperpigmentation on sun-exposed areas is attributed to an increase in melanin in the basal layer and superficial dermis due to failure of the kidneys to excrete beta-melanocyte stimulating hormone (β-MSH). 7,8,9,10 Perforating Dermatoses encountered in 3 patients clinically. Skin biopsy was done repeatedly for HPE.…”

Section: Specific Cutaneous Lesions Of Ckdmentioning

confidence: 99%

A Clinical Study of Cutaneous Manifestations of Chronic Kidney Disease

Aruna¹,

P²,

A³

et al. 2016

jemds

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BACKGROUNDThe kidneys and the skin are two important organs whose blood supply far exceeds their demand, the former for maintaining the milieu interior and the latter for rendering man homoeothermic. Changes of the skin are frequently seen in patients with kidney disease and in those who are undergoing dialysis. A number of diseases are characterised by distinctive cutaneous and renal manifestations. MATERIALS AND METHODSThis study spanned a course of 6 months from January 2011 to June 2011. During this period 82 patients admitted in the Nephrology ward of Osmania General Hospital for dialysis as well as those patients referred to the Dermatology Outpatient Department from the Nephrology Department were screened for evidence of cutaneous manifestations of kidney disease. Of these, 50 patients who had the presence of skin manifestations were selected and studied, both sexes and all age groups were included in the study. RESULTSOut of 50 patients in the age group of 1-70 years, (66%) maximum number of patients were observed between 3rd to 5th decade while least number in 1st and 2nd decade. Youngest Patient studied -Male, 7 Years. Oldest patient studied -Male, 69 Years. Xerosis or dryness of the skin was seen in 28 patients. 14 patients out 50 showed pallor. Pruritus was seen in 12 patients. Purpura was seen in 3 patients. Perforating dermatoses was seen in 3 patients. Fungal infections were seen in 9 patients. Bacterial infections were seen in 5 patients. Viral infections were seen in 4 patients. Scabies was seen in 2 patients. Sparse scalp hair was reported in 7. Specific nail changes were seen in 19 patients. CONCLUSIONSAmong the various cutaneous manifestations, xerosis and pigmentary changes topped the list of prevalence with Xerosis 56%, Pallor 28%. Pruritus was seen in 24% of patients. Nearly, 6% had perforating dermatosis. The Prevalence of hair abnormalities in our study was 14%. Prevalence of nail changes were seen in 38% of cases. Cutaneous infections were seen in 36% of patients.

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Plasma immunoreactive melanotrophic hormones in patients on maintenance haemodialysis.

Cited by 66 publications

References 13 publications

Cutaneous Abnormalities in Uremic Patients

Cutaneous Abnormalities in Uremic Patients

Simultaneous Assay of Immunoreactive β-Lipotropin, γ-Lipotropin, and β-Endorphin in Plasma of Normal Human Subjects, Patients with ACTH/Lipotropin Hypersecretory Syndromes, and Patients undergoing Chronic Hemodialysis

A Clinical Study of Cutaneous Manifestations of Chronic Kidney Disease

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