Plasma-derived extracellular matrix for xenofree and cost-effective organoid modeling for hepatocellular carcinoma
Azza M. El-Derby,
Mennatallah A. Khedr,
Nehal I. Ghoneim
et al.
Abstract:Background
Hepatocellular carcinoma (HCC) causes significant cancer mortality worldwide. Cancer organoids can serve as useful disease models by high costs, complexity, and contamination risks from animal-derived products and extracellular matrix (ECM) that limit its applications. On the other hand, synthetic ECM alternatives also have limitations in mimicking native biocomplexity. This study explores the development of a physiologically relevant HCC organoid model using plasma-derived extracell… Show more
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