Plasma Aspartate Aminotransferase Activity in the Catfish Clarias albopunctatus Exposed to Sublethal Zinc and Mercury

Oluah, Ndubuisi Stanley

doi:10.1007/s001289900986

Cited by 42 publications

(29 citation statements)

References 9 publications

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“…In the present study hepatic damage was confirmed by changes in ALAT and ASAT responses. Thus, our findings are in agreement with other authors (Rajyasree & Neeraja 1989;Oluah 1998Oluah , 1999 who stated that any changes in responses of ALAT and ASAT indicate tissue damage in organs such as the liver.…”

Section: Enzymatic Responsessupporting

confidence: 94%

Biomarkers in European perch (Perca fluviatilis) liver from a metal-contaminated dam lake

et al. 2014

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The present study was carried out in three seasons -spring, summer and autumn in Topolnitsa Dam Lake (Bulgaria) which has been subjected to continuous contamination with trace metals due to copper extraction in the area. We investigated the trace metal levels in surface water and liver samples of European perch (Perca fluviatilis L.). We also linked the metal levels we determined with the various histological and biochemical changes which we observed. Lesions in the liver parenchyma were found to be degenerative and necrotic, as well as, they were presented as hyperemia which consequently leads to disturbances in the hepatic blood circulation. Activities of the hepatic enzymes lactate dehydrogenase (LDH), alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT) were found to be significantly elevated, particularly in summer. Therefore, based on our results we could recommend that the investigated tissue and cell alterations may be successfully applied as reliable biomarkers for monitoring polluted with a mixture of trace metals freshwater ecosystems.

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Section: Enzymatic Responsessupporting

confidence: 94%

Biomarkers in European perch (Perca fluviatilis) liver from a metal-contaminated dam lake

et al. 2014

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“…They attributed the increase to tissue damage and impairment of fish metabolism. Oluah (1999) recorded increased AST activity in Clariaalbo punctatus exposed to Zn and Hg varying from 50 to 0.15 mg/L for 21 days. This increase in AST activity can be attributed to imbalances in the physiology and anatomy of the reservoir tissues.…”

Section: Hepatic Enzymesmentioning

confidence: 86%

Analysis of antioxidants and serum biochemical responses in goldfish under nickel exposure by sub-chronic test

Rahimikia

2016

Journal of Applied Animal Research

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The nickel impacts on antioxidant enzymes' activities such as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and hepatic enzymes' activity were studied in freshwater carassius auratus. Probite analysis was used to determine acute toxicity of nickel to the goldfish. Fish were subjected to selected concentrations of nickel (control 0, 10, 20, 50, 100, 150, 200, 250 and 300 ppm) and the mortality data were determined after 24, 48, 72 and 96 h. The 96 h LC50 value of nickel to the fish was found to be 95.39 ± 0.73 ppm. SOD, GPx and CAT activities were monitored in the liver. These were determined in goldfish exposed to sub-lethal concentrations (40% and 80% LC50 at 7 days of exposure). There was a marked increase in SOD within both exposure groups and GPx was observed in this tissue having exposure to nickel (P < .05) but CAT was decreased in both the groups (P < .05). AST, ALP, ALT enzymes' activity in both groups (40% and 80% LC50) was increased significantly when compared to that of the control group (P < .05). This result implied that increasing the dosage of nickel exposure induced antioxidant and hepatic enzymes' activity in the goldfish. ARTICLE HISTORY

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“…Aminotransferase enzymes (aspartate aminotransferase and alanine aminotransferase) are found in the liver, kidney, gills, intestine, brain, and other organs, and play a key role in fish protein and carbohydrate metabolism. These enzymes leak into blood plasma as a consequence of tissue damage or dysfunction (Ciereszko et al 1998;Oluah 1999). They had been extensively used to monitor the physiological status of fishes exposed to stressful conditions (Wells et al 1986;Poledník et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the physiological status of the Pacific sardine, Sardinops sagax caeruleus, acclimated to different thermal regimes based on selected blood parameters

et al. 2010

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Despite the widespread recognition of the importance of temperature in the population dynamics and distribution of Pacific sardine (Sardinops sagax caeruleus), few studies have examined the species' physiological response to temperature under controlled conditions. The effect of fluctuating thermal regimes on blood plasma cortisol, glucose, aspartate aminotransferase (ALT), alanine aminotransferase (AST) and red blood cell (RBC) counts of Pacific sardine was evaluated to monitor physiological response. Sardines from the southern subpopulation that inhabits waters off Baja California, Mexico, were collected during fall 2008. Acclimation to four fluctuating temperature regimes (two symmetric and two asymmetric) and a constant, optimal temperature occurred over 20 d. Symmetric and asymmetric regimes were designed to simulate regional summer (18-23°C) and winter (13-18°C) temperature ranges within 24 h. In the optimal regime (OR), sardines were acclimated to 18°C. In symmetric regimes, sardines were exposed for 7 h to the high and low temperatures, while in asymmetric regimes exposure to the high temperature was shorter (4 vs.10 h). Blood sampling took place during the low and high temperature exposure, and we tested for differences in blood parameters compared to OR. Plasma cortisol and glucose concentration of sardines from summer regimes were only significantly higher at 23°C. AST activities were significantly higher than OR during the high and low temperatures of both summer treatments. No differences were found in individuals exposed to the winter regimes. ALT activities were significantly higher than OR only during the high and low temperature of the symmetric summer regime. RBC were significantly higher than OR for both summer regimes. Sardines from southern subpopulation exhibit a negative physiological response to high temperatures, yet they can acclimate to the lower (≤18°C) temperatures typical of the California Current Environ Biol Fish (2011) 91:39-49

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Plasma Aspartate Aminotransferase Activity in the Catfish Clarias albopunctatus Exposed to Sublethal Zinc and Mercury

Cited by 42 publications

References 9 publications

Biomarkers in European perch (Perca fluviatilis) liver from a metal-contaminated dam lake

Biomarkers in European perch (Perca fluviatilis) liver from a metal-contaminated dam lake

Analysis of antioxidants and serum biochemical responses in goldfish under nickel exposure by sub-chronic test

Evaluation of the physiological status of the Pacific sardine, Sardinops sagax caeruleus, acclimated to different thermal regimes based on selected blood parameters

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