Plasma and cerebrospinal fluid amyloid beta for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)

Abstract

Plasma and cerebrospinal fluid amyloid beta for the diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).

Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways

“…MMSE assessments were not performed on control subjects. Corresponding with previous reports [54, 55], the MCI and AD subjects in this study had significantly reduced serum/CSF ratios reflecting decreased Aβ 1-42 clearance from the CNS. Initial analysis of the multiplex ELISA results revealed generally small differences between the MCI and early AD groups [50, 56].…”

Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways

“…MMSE assessments were not performed on control subjects. Corresponding with previous reports [54, 55], the MCI and AD subjects in this study had significantly reduced serum/CSF ratios reflecting decreased Aβ 1-42 clearance from the CNS. Initial analysis of the multiplex ELISA results revealed generally small differences between the MCI and early AD groups [50, 56].…”

Concordant and Discordant Cerebrospinal Fluid and Plasma Cytokine and Chemokine Responses in Mild Cognitive Impairment and Early-Stage Alzheimer’s Disease

“…The above questions were addressed by using a commercial 27-plex cytokine and chemokine ELISA to measure inflammatory markers in paired serum and CSF samples from research study participants diagnosed with MCI, early AD, or no underlying neurological disorder. Corresponding with previous reports, the MCI and AD cases had increased pTau and Aβ CSF/serum ratios, reflecting decreased brain clearances [117,118]. Furthermore, the progressive changes from MCI to AD correspond with the view that CNS clearances of both molecules decline with disease progression.…”

Validation of olfactory deficit as a biomarker of Alzheimer disease

“…28 The ROC AUC for the detection of AD vs controls is only slightly inferior to other, more invasive biomarkers. [29][30][31][32][33][34][35][36] The sensitivity and specificity of the 10-item short form is optimal at the cutoff of 7, similar to the alternative 10 reported by Tabert et al 28 The Tabert et al 28 top 10 resulted in similar AUC and has 4-item overlap with our set. Thus, the Tabert et al top 10 provides an alternative test with similar performance, establishing the basis for retesting.…”

Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways

“…MMSE assessments were not performed on control subjects. Corresponding with previous reports [54, 55], the MCI and AD subjects in this study had significantly reduced serum/CSF ratios reflecting decreased Aβ 1-42 clearance from the CNS. Initial analysis of the multiplex ELISA results revealed generally small differences between the MCI and early AD groups [50, 56].…”

Concordant and Discordant Cerebrospinal Fluid and Plasma Cytokine and Chemokine Responses in Mild Cognitive Impairment and Early-Stage Alzheimer’s Disease

“…The above questions were addressed by using a commercial 27-plex cytokine and chemokine ELISA to measure inflammatory markers in paired serum and CSF samples from research study participants diagnosed with MCI, early AD, or no underlying neurological disorder. Corresponding with previous reports, the MCI and AD cases had increased pTau and Aβ CSF/serum ratios, reflecting decreased brain clearances [117,118]. Furthermore, the progressive changes from MCI to AD correspond with the view that CNS clearances of both molecules decline with disease progression.…”

Validation of olfactory deficit as a biomarker of Alzheimer disease

“…28 The ROC AUC for the detection of AD vs controls is only slightly inferior to other, more invasive biomarkers. [29][30][31][32][33][34][35][36] The sensitivity and specificity of the 10-item short form is optimal at the cutoff of 7, similar to the alternative 10 reported by Tabert et al 28 The Tabert et al 28 top 10 resulted in similar AUC and has 4-item overlap with our set. Thus, the Tabert et al top 10 provides an alternative test with similar performance, establishing the basis for retesting.…”

Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways

“…MMSE assessments were not performed on control subjects. Corresponding with previous reports [54, 55], the MCI and AD subjects in this study had significantly reduced serum/CSF ratios reflecting decreased Aβ 1-42 clearance from the CNS. Initial analysis of the multiplex ELISA results revealed generally small differences between the MCI and early AD groups [50, 56].…”

Concordant and Discordant Cerebrospinal Fluid and Plasma Cytokine and Chemokine Responses in Mild Cognitive Impairment and Early-Stage Alzheimer’s Disease

“…The above questions were addressed by using a commercial 27-plex cytokine and chemokine ELISA to measure inflammatory markers in paired serum and CSF samples from research study participants diagnosed with MCI, early AD, or no underlying neurological disorder. Corresponding with previous reports, the MCI and AD cases had increased pTau and Aβ CSF/serum ratios, reflecting decreased brain clearances [117,118]. Furthermore, the progressive changes from MCI to AD correspond with the view that CNS clearances of both molecules decline with disease progression.…”

Validation of olfactory deficit as a biomarker of Alzheimer disease

“…28 The ROC AUC for the detection of AD vs controls is only slightly inferior to other, more invasive biomarkers. [29][30][31][32][33][34][35][36] The sensitivity and specificity of the 10-item short form is optimal at the cutoff of 7, similar to the alternative 10 reported by Tabert et al 28 The Tabert et al 28 top 10 resulted in similar AUC and has 4-item overlap with our set. Thus, the Tabert et al top 10 provides an alternative test with similar performance, establishing the basis for retesting.…”