1996
DOI: 10.1016/0735-1097(95)00504-8 View full text |Buy / Rent full text
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Abstract: Atrial and brain natriuretic peptides respond differently to changes in heart rate and atrial pressures. Reduced atrial tissue atrial natriuretic peptide levels in heart failure may indicate reduced storage after enhanced cardiac release. However, the relatively modest change in cardiac tissue brain natriuretic peptide levels suggests that the elevated plasma levels may be mediated by mechanisms other than increased atrial pressures.

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“…In normal dogs, canine ANP is suggested to be synthesized mainly in the atrium similar to human ANP [9]. On the other hand, canine BNP is demonstrated to be synthesized mainly in the atrium rather than the ventricle in healthy dogs in contrast to human BNP [2,9]. Therefore, the main origin of the secretion of both ANP and BNP in dogs with experimental MR is thought to be the LA wall due to volume-overload by MR.…”
Section: Discussionmentioning
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“…In normal dogs, canine ANP is suggested to be synthesized mainly in the atrium similar to human ANP [9]. On the other hand, canine BNP is demonstrated to be synthesized mainly in the atrium rather than the ventricle in healthy dogs in contrast to human BNP [2,9]. Therefore, the main origin of the secretion of both ANP and BNP in dogs with experimental MR is thought to be the LA wall due to volume-overload by MR.…”
Section: Discussionmentioning
“…In human, it has been demonstrated that ANP is mainly synthesized and secreted from the atrium and BNP mainly from the ventricle [11,20]. In normal dogs, canine ANP is suggested to be synthesized mainly in the atrium similar to human ANP [9]. On the other hand, canine BNP is demonstrated to be synthesized mainly in the atrium rather than the ventricle in healthy dogs in contrast to human BNP [2,9].…”
Section: Discussionmentioning
“…Twenty-nine mongrel dogs (18-36 kg) were prepared for rapid ventricular pacing as previously described (20)(21)(22). Briefly, under isoflurane anesthesia, a unipolar pacemaker lead was placed in the right ventricular apex under fluoroscopic visualization through the external jugular vein, and a…”
Section: Experimental Designmentioning
“…Chronic pacing in animals has been demonstrated to reliably produce LV dilation and myocardial remodeling (21,22,29,30). Moreover, previous studies have also demonstrated increased myocardial MMP levels that were temporally related to the onset of the LV remodeling process (29,30).…”
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